Laboratory Parameters Associated With Inflammation Do Not Affect PD-L1 Expression in Non-small Cell Lung Cancer.
Aged
B7-H1 Antigen
/ analysis
Biomarkers, Tumor
/ analysis
C-Reactive Protein
/ analysis
Carcinoma, Non-Small-Cell Lung
/ immunology
Female
Hemoglobins
/ analysis
Humans
Lung Neoplasms
/ immunology
Lymphocytes
/ immunology
Male
Middle Aged
Neoplasm Staging
Neutrophils
/ immunology
Registries
Retrospective Studies
Serum Albumin, Human
/ analysis
CRP
NLR
NSCLC
PD-L1
albumin
haemoglobin
inflammation
lung cancer
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
20
01
2022
revised:
06
02
2022
accepted:
07
02
2022
entrez:
27
2
2022
pubmed:
28
2
2022
medline:
8
3
2022
Statut:
ppublish
Résumé
Due to some interconnectedness at the molecular level, this study assessed the possible influence of laboratory parameters associated with systemic inflammatory environment on programmed death-ligand 1 (PD-L1) expression in non-small cell lung carcinoma (NSCLC). We assessed effects of c-reactive protein (CRP), albumin, haemoglobin, neutrophil, and lymphocyte levels on PD-L1 expression in NSCLC. Patient data were obtained retrospectively from LUCAS, the Czech registry of patients with lung carcinomas. Correlations of two continuous parameters (PD-L1 expression and laboratory parameters) were analysed by correlation coefficient. Differences in continuous parameters between two or more groups were tested by Mann-Whitney or Kruskal-Wallis tests. Independence of two categorical parameters was tested by chi-square test. We demonstrated no influence of the investigated laboratory parameters on PD-L1 expression in NSCLC, either in continuous or categorical division of variables. Inflammatory laboratory parameters at time of NSCLC diagnosis are unlikely to affect the determination of PD-L1 expression.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
Due to some interconnectedness at the molecular level, this study assessed the possible influence of laboratory parameters associated with systemic inflammatory environment on programmed death-ligand 1 (PD-L1) expression in non-small cell lung carcinoma (NSCLC).
PATIENTS AND METHODS
METHODS
We assessed effects of c-reactive protein (CRP), albumin, haemoglobin, neutrophil, and lymphocyte levels on PD-L1 expression in NSCLC. Patient data were obtained retrospectively from LUCAS, the Czech registry of patients with lung carcinomas. Correlations of two continuous parameters (PD-L1 expression and laboratory parameters) were analysed by correlation coefficient. Differences in continuous parameters between two or more groups were tested by Mann-Whitney or Kruskal-Wallis tests. Independence of two categorical parameters was tested by chi-square test.
RESULTS
RESULTS
We demonstrated no influence of the investigated laboratory parameters on PD-L1 expression in NSCLC, either in continuous or categorical division of variables.
CONCLUSION
CONCLUSIONS
Inflammatory laboratory parameters at time of NSCLC diagnosis are unlikely to affect the determination of PD-L1 expression.
Identifiants
pubmed: 35220253
pii: 42/3/1563
doi: 10.21873/anticanres.15630
doi:
Substances chimiques
ALB protein, human
0
B7-H1 Antigen
0
Biomarkers, Tumor
0
CD274 protein, human
0
Hemoglobins
0
C-Reactive Protein
9007-41-4
Serum Albumin, Human
ZIF514RVZR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1563-1569Informations de copyright
Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.