An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir.
Journal
Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056
Informations de publication
Date de publication:
09 03 2022
09 03 2022
Historique:
pubmed:
1
3
2022
medline:
18
3
2022
entrez:
28
2
2022
Statut:
ppublish
Résumé
The Covid-19 pandemic highlights the urgent need for cost-effective processes to rapidly manufacture antiviral drugs at scale. Here we report a concise biocatalytic process for Molnupiravir, a nucleoside analogue recently approved as an orally available treatment for SARS-CoV-2. Key to the success of this process was the development of an efficient biocatalyst for the production of
Identifiants
pubmed: 35224970
doi: 10.1021/jacs.1c11048
pmc: PMC8915250
doi:
Substances chimiques
Antiviral Agents
0
Hydroxylamines
0
Cytidine
5CSZ8459RP
Cytidine Deaminase
EC 3.5.4.5
Uridine
WHI7HQ7H85
molnupiravir
YA84KI1VEW
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3761-3765Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M017702/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M027023/1
Pays : United Kingdom
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