Epitope Mapping of Rituximab Using HisMAP Method.

Animals Antibodies, Monoclonal Antigens, CD20 Epitope Mapping Epitopes Mice Rituximab
CD20 His tag epitope mapping monoclonal antibody rituximab

Journal

Monoclonal antibodies in immunodiagnosis and immunotherapy
ISSN: 2167-9436
Titre abrégé: Monoclon Antib Immunodiagn Immunother
Pays: United States
ID NLM: 101590955

Informations de publication

Date de publication:
Feb 2022
Historique:
entrez: 28 2 2022
pubmed: 1 3 2022
medline: 3 3 2022
Statut: ppublish

Résumé

CD20 is expressed in the B lymphocyte, and an effective target for the detection and treatment of B cell lymphomas. Therefore, CD20 has been studied as a therapeutic target of B cell lymphomas and autoimmune disorders. Specific anti-CD20 monoclonal antibodies (mAbs), such as rituximab, ofatumumab, veltuzumab, and ocaratuzumab, have been developed. Revealing the recognition mechanism of antigen by mAbs could contribute to understanding the function of mAbs and could be useful for the development of vaccine. Rituximab is a mouse-human chimeric anti-CD20 mAb, which was developed and approved for the treatment of the B cell malignancies. Hence, the binding epitope of rituximab for CD20 has been studied. Some reports show that

Identifiants

DOI: 10.1089/mab.2021.0044 PMID: 35225667
pubmed: 35225667
doi: 10.1089/mab.2021.0044
doi:

Substances chimiques

Antibodies, Monoclonal 0
Antigens, CD20 0
Epitopes 0
Rituximab 4F4X42SYQ6

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8-14

Auteurs

Teizo Asano (T)

Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.

Hiroyuki Suzuki (H)

Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Mika K Kaneko (MK)

Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.

Yukinari Kato (Y)

Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.
Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan.
ORCID: 0000-0001-5385-8201

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Epitope Mapping of Rituximab Using HisMAP Method.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Epitope Mapping of Rituximab Using HisMAP Method.
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes B › Antigènes CD20 › Epitope Mapping of Rituximab Using HisMAP Method.
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Cartographie d'interactions entre protéines › Cartographie épitopique › Epitope Mapping of Rituximab Using HisMAP Method.
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Epitope Mapping of Rituximab Using HisMAP Method.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Epitope Mapping of Rituximab Using HisMAP Method.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Anticorps monoclonaux d'origine murine › Rituximab › Epitope Mapping of Rituximab Using HisMAP Method.