Effects of a Combination of Arginine Silicate Inositol Complex and a Novel Form of Biotin on Hair and Nail Growth in a Rodent Model.
Arginine silicate
Biotin
Hair
Magnesium
Nail
Journal
Biological trace element research
ISSN: 1559-0720
Titre abrégé: Biol Trace Elem Res
Pays: United States
ID NLM: 7911509
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
23
12
2021
accepted:
21
02
2022
pubmed:
1
3
2022
medline:
21
1
2023
entrez:
28
2
2022
Statut:
ppublish
Résumé
The purpose of this study was to examine the effects of a combination of inositol-stabilized arginine silicate complex (ASI) and magnesium biotinate (MgB) on hair and nail growth in an animal model. Twenty-eight female Sprague-Dawley rats (8 weeks old) were randomized into one of the following groups: (i) group (control), shaved; (ii) group (ASI), shaved + ASI (4.14 mg/rat/day); (iii) group (ASI + MgB I), shaved + ASI (4.14 mg/rat/day) + MgB (48.7 μg/rat/day); and (iv) group (ASI + MgB II), shaved + ASI (4.14 mg/rat/day) + MgB (325 μg/rat/day). On day 42, compared with the control group, while hair density (p < 0.05, p < 0.01, and p < 0.0001, respectively) and anagen ratio (p < 0.01, p < 0.01, and p < 0.001) increased in the ASI, ASI + MgB I, and ASI + MgB II groups, telogen ratio decreased (p < 0.01, p < 0.01, and p < 0.001, respectively). In the molecular analysis, VEGF, HGF, and KGF-2 increased in the ASI (p < 0.01, p < 0.01, and p < 0.05, respectively), ASI + MgB I (p < 0.0001 for all), and ASI + MgB II (p < 0.0001 for all) groups when compared to the control group. FGF-2 (p < 0.01) and IGF-1 (p < 0.001) were found to be increased in the ASI + MgB I and ASI + MgB II groups. SIRT-1 and β-catenin increased in the ASI (p < 0.05 and p < 0.01), ASI + MgB I (p < 0.001 for both), and ASI + MgB II (p < 0.0001 for both) groups. Wnt-1 increased in the ASI + MgB I (p < 0.001) and ASI + MgB II (p < 0.0001) groups. In conclusion, the combination of ASI and MgB could promote hair growth by regulating IGF-1, FGF, KGF, HGF, VEGF, SIRT-1, Wnt, and β-catenin signal pathways. It was also established that ASI did not affect nail growth, whereas the MgB combination was effective using a higher dose of biotin.
Identifiants
pubmed: 35226275
doi: 10.1007/s12011-022-03176-9
pii: 10.1007/s12011-022-03176-9
pmc: PMC8883010
doi:
Substances chimiques
Inositol
4L6452S749
Biotin
6SO6U10H04
Insulin-Like Growth Factor I
67763-96-6
beta Catenin
0
Arginine
94ZLA3W45F
Vascular Endothelial Growth Factor A
0
Silicates
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
751-765Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Market size of beauty salons (hair, skin, nails) in the United States from 2017 to 2021. https://www.statista.com/statistics/296193/revenue-hair-and-nail-salons-in-the-us
Alonso LC, Rosenfield RL (2003) Molecular genetic and endocrine mechanisms of hair growth. Horm Res Paediatr 60:1–13. https://doi.org/10.1159/000070821
doi: 10.1159/000070821
Cashman MW, Sloan SB (2010) Nutrition and nail disease. Clin Dermatol 28:420–425. https://doi.org/10.1016/j.clindermatol.2010.03.037
doi: 10.1016/j.clindermatol.2010.03.037
Vinay K, Sawatkar G, Dogra S (2018) Hair manifestations of endocrine diseases: a brief review. Indian J Dermatol Venereol Leprol 84:528–538. https://doi.org/10.4103/ijdvl.IJDVL_671_17
doi: 10.4103/ijdvl.IJDVL_671_17
Madaan A, Verma R, Singh AT, Jaggi M (2018) Review of hair follicle dermal papilla cells as in vitro screening model for hair growth. Int J Cosmet Sci 40:429–450. https://doi.org/10.1111/ics.12489
doi: 10.1111/ics.12489
Harrison S, Bergfeld W (2009) Diffuse hair loss: its triggers and management. Cleve Clin J Med 76:361–367. https://doi.org/10.3949/ccjm.76a.08080
doi: 10.3949/ccjm.76a.08080
Huh S, Lee J, Jung E et al (2009) A cell-based system for screening hair growth-promoting agents. Arch Dermatol Res 301:381–385. https://doi.org/10.1007/s00403-009-0931-0
doi: 10.1007/s00403-009-0931-0
Morris SM (2016) Arginine metabolism revisited. J Nutr 146:2579S-2586S. https://doi.org/10.3945/jn.115.226621
doi: 10.3945/jn.115.226621
Rosenthal MD, Carrott PW, Patel J et al (2016) Parenteral or enteral arginine supplementation safety and efficacy. J Nutr 146:2594S-2600S. https://doi.org/10.3945/jn.115.228544
doi: 10.3945/jn.115.228544
Ahsan H (2019) Immunopharmacology and immunopathology of peptides and proteins in personal products. J Immunoass Immunochem 40:439–447. https://doi.org/10.1080/15321819.2019.1629590
doi: 10.1080/15321819.2019.1629590
Xue Y, Lu Q, Tian Y et al (2017) Effect of toothpaste containing arginine on dental plaque—a randomized controlled in situ study. J Dent 67:88–93. https://doi.org/10.1016/j.jdent.2017.10.001
doi: 10.1016/j.jdent.2017.10.001
Kalman DS, Feldman S, Samson A, Krieger DR (2015) A clinical evaluation to determine the safety, pharmacokinetics, and pharmacodynamics of an inositol-stabilized arginine silicate dietary supplement in healthy adult males. Clin Pharmacol 7:103–109. https://doi.org/10.2147/CPAA.S84206
doi: 10.2147/CPAA.S84206
Zempleni J, Wijeratne SSK, Hassan YI (2009) Biotin Biofactors 35:36–46. https://doi.org/10.1002/biof.8
doi: 10.1002/biof.8
Zempleni J, Wijeratne SSK, Kuroishi T (2012) Biotin. Present knowledge in nutrition. Wiley-Blackwell, Oxford, UK, pp 359–374
doi: 10.1002/9781119946045.ch23
Almohanna HM, Ahmed AA, Tsatalis JP, Tosti A (2019) The role of vitamins and minerals in hair loss: a review. Dermatol Ther (Heidelb) 9:51–70. https://doi.org/10.1007/s13555-018-0278-6
doi: 10.1007/s13555-018-0278-6
Patel DP, Swink SM, Castelo-Soccio L (2017) A Review of the use of biotin for hair loss. Skin Appendage Disord 3(3):166–169. https://doi.org/10.1159/000462981
doi: 10.1159/000462981
Gröber U, Schmidt J, Kisters K (2015) Magnesium in prevention and therapy. Nutrients 7:8199–8226. https://doi.org/10.3390/nu7095388
doi: 10.3390/nu7095388
Zhang Y, Xun P, Wang R et al (2017) Can magnesium enhance exercise performance? Nutrients 9:946. https://doi.org/10.3390/nu9090946
doi: 10.3390/nu9090946
Nielsen FH (2010) Magnesium, inflammation, and obesity in chronic disease. Nutr Rev 68:333–340. https://doi.org/10.1111/j.1753-4887.2010.00293.x
doi: 10.1111/j.1753-4887.2010.00293.x
Skalnaya MG, Skalny AV, Grabeklis AR et al (2018) Hair trace elements in overweight and obese adults in association with metabolic parameters. Biol Trace Elem Res 186:12–20. https://doi.org/10.1007/s12011-018-1282-5
doi: 10.1007/s12011-018-1282-5
Rathman SC, Gregory JF, McMahon RJ (2003) Pharmacological biotin supplementation maintains biotin status and function in rats administered dietary carbamazepine. J Nutr 133:2857–2862. https://doi.org/10.1093/jn/133.9.2857
doi: 10.1093/jn/133.9.2857
Kim M-H, Bae Y-J, Choi M-K, Chung Y-S (2009) Silicon supplementation improves the bone mineral density of calcium-deficient ovariectomized rats by reducing bone resorption. Biol Trace Elem Res 128:239–247. https://doi.org/10.1007/s12011-008-8273-x
doi: 10.1007/s12011-008-8273-x
Kim M-H, Choi M-K (2021) Effect of silicon supplementation in diets with different calcium levels on balance of calcium, silicon and magnesium, and bone status in growing female rats. Biol Trace Elem Res 199:258–266. https://doi.org/10.1007/s12011-020-02147-2
doi: 10.1007/s12011-020-02147-2
Reeves PG, Nielsen FH, Fahey GC (1993) AIN-93 purified diets for laboratory rodents: Final report of the american institute of nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123:1939–1951. https://doi.org/10.1093/jn/123.11.1939
doi: 10.1093/jn/123.11.1939
Wolf B, Grier RE, Allen RJ et al (1983) Biotinidase deficiency: the enzymatic defect in late-onset multiple carboxylase deficiency. Clin Chim Acta 131:273–281. https://doi.org/10.1016/0009-8981(83)90096-7
doi: 10.1016/0009-8981(83)90096-7
Giorgi MG, Howland K, Martin C, Bonner AB (2012) A novel HPLC method for the concurrent analysis and quantitation of seven water-soluble vitamins in biological fluids (plasma and urine): a validation study and application. Scientific World Journal 2012:359721. https://doi.org/10.1100/2012/359721
doi: 10.1100/2012/359721
Lewis B, Rathman S, McMahon R (2001) Dietary biotin intake modulates the pool of free and protein-bound biotin in rat liver. J Nutr 131:2310–2315. https://doi.org/10.1093/jn/131.9.2310
doi: 10.1093/jn/131.9.2310
Pieper GM, Dondlinger LA (1997) Plasma and vascular tissue arginine are decreased in diabetes: acute arginine supplementation restores endothelium-dependent relaxation by augmenting cGMP production. J Pharmacol Exp Ther 283:684–691
Tong T, Kim N, Park T (2015) Topical application of oleuropein induces anagen hair growth in telogen mouse skin. PLoS ONE 10:e0129578. https://doi.org/10.1371/journal.pone.0129578
doi: 10.1371/journal.pone.0129578
Enshell-Seijffers D, Lindon C, Kashiwagi M, Morgan BA (2010) β-catenin activity in the dermal papilla regulates morphogenesis and regeneration of hair. Dev Cell 18:633–642. https://doi.org/10.1016/j.devcel.2010.01.016
doi: 10.1016/j.devcel.2010.01.016
Rossi A, Cantisani C, Melis L et al (2012) Minoxidil Use in dermatology, side effects and recent patents. Recent Pat Inflamm Allergy Drug Discov 6:130–136. https://doi.org/10.2174/187221312800166859
doi: 10.2174/187221312800166859
Herman A, Herman AP (2016) Mechanism of action of herbs and their active constituents used in hair loss treatment. Fitoterapia 114:18–25. https://doi.org/10.1016/j.fitote.2016.08.008
doi: 10.1016/j.fitote.2016.08.008
Lin W, Xiang L-J, Shi H-X et al (2015) Fibroblast growth factors stimulate hair growth through β -catenin and Shh expression in C57BL/6 mice. Biomed Res Int 2015:1–9. https://doi.org/10.1155/2015/730139
doi: 10.1155/2015/730139
Braun S, Krampert M, Bodó E et al (2006) Keratinocyte growth factor protects epidermis and hair follicles from cell death induced by UV irradiation, chemotherapeutic or cytotoxic agents. J Cell Sci 119:4841–4849. https://doi.org/10.1242/jcs.03259
doi: 10.1242/jcs.03259
Lee Y-R, Yamazaki M, Mitsui S et al (2001) Hepatocyte growth factor (HGF) activator expressed in hair follicles is involved in in vitro HGF-dependent hair follicle elongation. J Dermatol Sci 25:156–163. https://doi.org/10.1016/S0923-1811(00)00124-9
doi: 10.1016/S0923-1811(00)00124-9
Panchaprateep R, Asawanonda P (2014) Insulin-like growth factor-1: roles in androgenetic alopecia. Exp Dermatol 23:216–218. https://doi.org/10.1111/exd.12339
doi: 10.1111/exd.12339
Buga GM, Wei LH, Bauer PM et al (1998) N G -hydroxy- l -arginine and nitric oxide inhibit Caco-2 tumor cell proliferation by distinct mechanisms. Am J Physiol Integr Comp Physiol 275:R1256–R1264. https://doi.org/10.1152/ajpregu.1998.275.4.R1256
doi: 10.1152/ajpregu.1998.275.4.R1256
Shapiro J, Lui H (2001) Vaniqa--eflornithine 13.9% cream. Skin Therapy Lett 6(7):1–3, 5.
Bhatt TS, Beltran LM, Walker SE, DiGiovanni J (1992) Induction of epidermal ornithine decarboxylase activity in mouse skin exposed to biogenic silica fibers. Carcinogenesis 13:617–620. https://doi.org/10.1093/carcin/13.4.617
doi: 10.1093/carcin/13.4.617
Yazdani-Arazi SN, Ghanbarzadeh S, Adibkia K et al (2017) Histological evaluation of follicular delivery of arginine via nanostructured lipid carriers: a novel potential approach for the treatment of alopecia. Artif Cells, Nanomedicine, Biotechnol 45:1379–1387. https://doi.org/10.1080/21691401.2016.1241794
doi: 10.1080/21691401.2016.1241794
Callender VD, Belpulsi D (2019) Biotin alone or a science-driven nutraceutical multi-targeted approach? J Drugs Dermatol 18:952–953
Lipner SR, Scher RK (2018) Biotin for the treatment of nail disease: what is the evidence? J Dermatolog Treat 29:411–414. https://doi.org/10.1080/09546634.2017.1395799
doi: 10.1080/09546634.2017.1395799
Mei Z, Zhang X, Yi J et al (2016) Sirtuins in metabolism, DNA repair and cancer. J Exp Clin Cancer Res 35:182. https://doi.org/10.1186/s13046-016-0461-5
doi: 10.1186/s13046-016-0461-5
Liu J, Xu Y, Wu Q et al (2018) Sirtuin-1 protects hair follicle stem cells from TNFα-mediated inflammatory stress via activating the MAPK-ERK-Mfn2 pathway. Life Sci 212:213–224. https://doi.org/10.1016/j.lfs.2018.10.003
doi: 10.1016/j.lfs.2018.10.003
Almeida Scalvino S, Chapelle A, Hajem N et al (2018) Efficacy of an agonist of α -MSH, the palmitoyl tetrapeptide-20, in hair pigmentation. Int J Cosmet Sci 40:516–524. https://doi.org/10.1111/ics.12494
doi: 10.1111/ics.12494
Rizk SM, El-Maraghy SA, Nassar NN (2014) A novel role for SIRT-1 in L-arginine protection against STZ induced myocardial fibrosis in rats. PLoS ONE 9:e114560. https://doi.org/10.1371/journal.pone.0114560
doi: 10.1371/journal.pone.0114560
Pittayapruek P, Meephansan J, Prapapan O et al (2016) Role of matrix metalloproteinases in photoaging and photocarcinogenesis. Int J Mol Sci 17:868. https://doi.org/10.3390/ijms17060868
doi: 10.3390/ijms17060868
Hou C, Miao Y, Wang J et al (2015) Collagenase IV plays an important role in regulating hair cycle by inducing VEGF, IGF-1, and TGF-β expression. Drug Des Devel Ther 9:5373–5383. https://doi.org/10.2147/dddt.s8912
doi: 10.2147/dddt.s8912
Hou C, Miao Y, Wang X et al (2016) Expression of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases in the hair cycle. Exp Ther Med 12:231–237. https://doi.org/10.3892/etm.2016.3319
doi: 10.3892/etm.2016.3319
Wu G, Bazer FW, Burghardt RC et al (2011) Proline and hydroxyproline metabolism: implications for animal and human nutrition. Amino Acids 40:1053–1063. https://doi.org/10.1007/s00726-010-0715-z
doi: 10.1007/s00726-010-0715-z
Kumar Srivastava A, Khare P, Kumar Nagar H et al (2016) Hydroxyproline: a potential biochemical marker and its role in the pathogenesis of different diseases. Curr Protein Pept Sci 17:596–602. https://doi.org/10.2174/1389203717666151201192247
doi: 10.2174/1389203717666151201192247
Xu ZC, Zhang Q, Li H (2017) Engineering of the human vessel wall with hair follicle stem cells in vitro. Mol Med Rep 15:417–422. https://doi.org/10.3892/mmr.2016.6013
doi: 10.3892/mmr.2016.6013
Zempleni J, Hassan YI, Wijeratne SS (2008) Biotin and biotinidase deficiency. Expert Rev Endocrinol Metab 3:715–724. https://doi.org/10.1586/17446651.3.6.715
doi: 10.1586/17446651.3.6.715
Tong L (2013) Structure and function of biotin-dependent carboxylases. Cell Mol Life Sci 70:863–891. https://doi.org/10.1007/s00018-012-1096-0
doi: 10.1007/s00018-012-1096-0
Xu J, Han J, Long YS et al (2008) The role of pyruvate carboxylase in insulin secretion and proliferation in rat pancreatic beta cells. Diabetologia 51:2022–2030. https://doi.org/10.1007/s00125-008-1130-9
doi: 10.1007/s00125-008-1130-9
Wongkittichote P, Ah Mew N, Chapman KA (2017) Propionyl-CoA carboxylase – a review. Mol Genet Metab 122:145–152. https://doi.org/10.1016/j.ymgme.2017.10.002
doi: 10.1016/j.ymgme.2017.10.002
Famenini S, Goh C (2014) Evidence for supplemental treatments in androgenetic alopecia. J Drugs Dermatol 13:809–812
Ojalvo SP, Sylla S, Komorowski J, Orhan C, Tuzcu M, Sahin N, Sahin K (2019) The Safety and absorption of magnesium biotinate in rats . Curr Dev Nutr 3:Supplement_1, (P06-029–19), nzz031.P06–029–19. https://doi.org/10.1093/cdn/nzz031.P06-029-19