Genetic contribution to the etiology of Achilles tendon rupture. A Danish nationwide register study of twins.
ATR
Achilles tendon
Achilles tendon rupture
Etiology
Genetics
Heritability
Pathogenesis
Risk factor
Rupture
Twin registry
Twin-study
tendon
Journal
Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons
ISSN: 1460-9584
Titre abrégé: Foot Ankle Surg
Pays: France
ID NLM: 9609647
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
16
01
2022
revised:
17
02
2022
accepted:
22
02
2022
pubmed:
2
3
2022
medline:
5
10
2022
entrez:
1
3
2022
Statut:
ppublish
Résumé
It is unknown if genetics contribute to the etiology of acute Achilles tendon rupture (ATR). The aims of the present study were, 1) To calculate the concordance rate for monozygotic (MZ) twins and same-sex dizygotic (SSDZ) twins and 2) to estimate the heritability of ATR. The study was performed as a registry study using the Danish Twin Registry and the Danish National Patient Registry. The study sample consisted of 85,534 twins born from 1895 to 1995. Of these, 572 (0.67%) were registered with ATR in the period from 1994 to 2014. The concordance rate was 8.1% (95% CI 1.4-14.7%) for MZ twins and 4.3% (95% CI 0.7-7.9%) for SSDZ twins. The heritability of ATR was 47% (95% CI 31-62%). This study found that genetics contribute substantially to the etiology of ATR with an estimated heritability of the liability to ATR of approximately 50%. The finding generates the hypothesis that genetics play a role in the pathological changes that occur in the Achilles tendon before a rupture. The risk of ATR for a twin within a 20 year period, if the co-twin has had an ATR, was 8% for MZ twins and 4% for SSDZ twins.
Sections du résumé
BACKGROUND
BACKGROUND
It is unknown if genetics contribute to the etiology of acute Achilles tendon rupture (ATR). The aims of the present study were, 1) To calculate the concordance rate for monozygotic (MZ) twins and same-sex dizygotic (SSDZ) twins and 2) to estimate the heritability of ATR.
METHODS
METHODS
The study was performed as a registry study using the Danish Twin Registry and the Danish National Patient Registry.
RESULTS
RESULTS
The study sample consisted of 85,534 twins born from 1895 to 1995. Of these, 572 (0.67%) were registered with ATR in the period from 1994 to 2014. The concordance rate was 8.1% (95% CI 1.4-14.7%) for MZ twins and 4.3% (95% CI 0.7-7.9%) for SSDZ twins. The heritability of ATR was 47% (95% CI 31-62%).
CONCLUSION
CONCLUSIONS
This study found that genetics contribute substantially to the etiology of ATR with an estimated heritability of the liability to ATR of approximately 50%. The finding generates the hypothesis that genetics play a role in the pathological changes that occur in the Achilles tendon before a rupture. The risk of ATR for a twin within a 20 year period, if the co-twin has had an ATR, was 8% for MZ twins and 4% for SSDZ twins.
Identifiants
pubmed: 35227591
pii: S1268-7731(22)00046-7
doi: 10.1016/j.fas.2022.02.015
pii:
doi:
Types de publication
Journal Article
Twin Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1050-1054Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.