Age-related differences in SARS-CoV-2 binding factors: An explanation for reduced susceptibility to severe COVID-19 among children?

Child Humans SARS-CoV-2 / metabolism COVID-19 Peptidyl-Dipeptidase A / metabolism Spike Glycoprotein, Coronavirus / metabolism
ACE2 COVID-19 Furin Paediatric SARS-CoV-2 TMPRSS2

Journal

Paediatric respiratory reviews
ISSN: 1526-0550
Titre abrégé: Paediatr Respir Rev
Pays: England
ID NLM: 100898941

Informations de publication

Date de publication:
Dec 2022
Historique:
received: 08 11 2021
revised: 07 01 2022
accepted: 12 01 2022
pubmed: 2 3 2022
medline: 15 12 2022
entrez: 1 3 2022
Statut: ppublish

Résumé

In contrast with other respiratory viruses, children infected with SARS-CoV-2 are largely spared from severe COVID-19. To critically assess age-related differences in three host proteins involved in SARS-CoV-2 cellular entry: angiotensin-converting enzyme 2 (ACE2), transmembrane serine protease 2 (TMPRSS2) and furin. We systematically searched Medline, Embase, and PubMed databases for relevant publications. Studies were eligible if they evaluated ACE2, TMPRSS2 or furin expression, methylation, or protein level in children. Sixteen papers were included. Age-dependent differences in membrane-bound and soluble ACE2 were shown in several studies, with ACE2 expression increasing with age. TMPRSS2 and furin are key proteases involved in SARS-CoV-2 spike protein cleavage. TMPRSS2 expression is increased by circulating androgens and is thus low in pre-pubertal children. Furin has not currently been well researched. High levels of study heterogeneity. Low expression of key host proteins may partially explain the reduced incidence of severe COVID-19 among children, although further research is needed.

Identifiants

DOI: 10.1016/j.prrv.2022.01.008 PMID: 35227628 PMC: PMC8823960
pubmed: 35227628
pii: S1526-0542(22)00009-4
doi: 10.1016/j.prrv.2022.01.008
pmc: PMC8823960
pii:
doi:

Substances chimiques

spike protein, SARS-CoV-2 0
Peptidyl-Dipeptidase A EC 3.4.15.1
Spike Glycoprotein, Coronavirus 0

Types de publication

Systematic Review Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

61-69

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Auteurs

Thomas Abrehart (T)

Department of Paediatrics, the University of Melbourne, Parkville, Australia. Electronic address: tabrehart@student.unimelb.edu.au.

Randy Suryadinata (R)

Department of Respiratory Medicine, Royal Children's Hospital, Melbourne, Victoria, Australia; Infection and Immunity, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia.

Conor McCafferty (C)

Department of Paediatrics, the University of Melbourne, Parkville, Australia; Haematology, Murdoch Children's Research Institute, Melbourne, Australia.

Jonathan Jacobson (J)

Infection and Immunity, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia; Department of Microbiology and Immunology, the University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.

Vera Ignjatovic (V)

Department of Paediatrics, the University of Melbourne, Parkville, Australia; Haematology, Murdoch Children's Research Institute, Melbourne, Australia.

Phil Robinson (P)

Department of Paediatrics, the University of Melbourne, Parkville, Australia; Department of Respiratory Medicine, Royal Children's Hospital, Melbourne, Victoria, Australia; Infection and Immunity, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia.

Nigel W Crawford (NW)

Department of Paediatrics, the University of Melbourne, Parkville, Australia; Infection and Immunity, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia.

Paul Monagle (P)

Department of Paediatrics, the University of Melbourne, Parkville, Australia; Haematology, Murdoch Children's Research Institute, Melbourne, Australia; Department of Haematology, Royal Children's Hospital, Parkville, Australia; Kids Cancer Centre, Sydney Children's Hospital, Randwick, Australia.

Kanta Subbarao (K)

WHO Collaborating Centre for Reference and Research on Influenza, the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia; Department of Microbiology and Immunology, the University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.

Catherine Satzke (C)

Department of Paediatrics, the University of Melbourne, Parkville, Australia; Infection and Immunity, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia; Department of Microbiology and Immunology, the University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.

Danielle Wurzel (D)

Department of Paediatrics, the University of Melbourne, Parkville, Australia; Department of Respiratory Medicine, Royal Children's Hospital, Melbourne, Victoria, Australia; Infection and Immunity, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia; Melbourne School of Population and Global Health, the University of Melbourne, Melbourne, Victoria, Australia.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Age-related differences in SARS-CoV-2 binding...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Age-related differences in SARS-CoV-2 binding...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Age-related differences in SARS-CoV-2 binding...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Age-related differences in SARS-CoV-2 binding...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Exopeptidases › Dipeptidyl-Peptidases and Tripeptidyl-Peptidases › Peptidyl-Dipeptidase A › Age-related differences in SARS-CoV-2 binding...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Protéines de fusion virale › Glycoprotéine de spicule des coronavirus › Age-related differences in SARS-CoV-2 binding...