Epothilone D Modulates Autism-like Behaviors in the BTBR Mouse Model of Autism Spectrum Disorder.
BTBR mice
autism spectrum disorder
epothilone D
myelin
synapse
Journal
Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074
Informations de publication
Date de publication:
10 05 2022
10 05 2022
Historique:
received:
04
12
2021
revised:
17
02
2022
accepted:
21
02
2022
pubmed:
2
3
2022
medline:
27
4
2022
entrez:
1
3
2022
Statut:
ppublish
Résumé
Autism spectrum disorder (ASD) is a neurodevelopmental disorder, characterized by impaired social communication, abnormal repetitive behaviors and restricted interests and/or sensory behaviors. It has been widely accepted that ASD involves a complex interplay of both genetic and environmental risk factors. Existing medications are only symptomatic treatments, there are no effective treatments that can improve these core social behavior deficits. Recent studies indicated that synaptic development and abnormal myelination are linked to the pathogenesis of ASD. The stable tubule only polypeptide (STOP) protein, also known as microtubule-associated protein 6, plays an important role in neuronal development and synaptic plasticity. Our previous studies showed that STOP protein was significantly reduced in the plasma of autistic subjects and in the cortex of BTBR T
Identifiants
pubmed: 35227832
pii: S0306-4522(22)00095-1
doi: 10.1016/j.neuroscience.2022.02.025
pii:
doi:
Substances chimiques
Epothilones
0
Myelin Proteins
0
desoxyepothilone B
T0358E0YUF
Dimethyl Sulfoxide
YOW8V9698H
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
171-181Informations de copyright
Copyright © 2022 IBRO. Published by Elsevier Ltd. All rights reserved.