Association of perinatal sentinel events, placental pathology and cerebral MRI in neonates with hypoxic-ischemic encephalopathy receiving therapeutic hypothermia.
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
26
07
2021
accepted:
11
02
2022
revised:
06
01
2022
pubmed:
2
3
2022
medline:
9
7
2022
entrez:
1
3
2022
Statut:
ppublish
Résumé
Placental pathology might provide information on the etiology of hypoxic-ischemic encephalopathy (HIE). To evaluate the association of perinatal sentinel events (PSE), placental pathology and cerebral MRI in cooled neonates with moderate/severe HIE. Retrospective analysis of 52 neonates with HIE registered in the Swiss National Asphyxia and Cooling Register 2011-2019. PSE and Non-PSE groups were tested for association with placental pathology. Placental pathology categories were correlated with MRI scores. In total, 14/52 neonates (27%) had a PSE, 38 neonates (73%) did not have a PSE. There was no evidence for an association of occurrence of PSE and placental pathologies (p = 0.364). Neonates with high MRI scores tended to have more often chronic pathologies in their placentas than acute pathologies or normal placentas (p = 0.067). Independent of the occurrence of PSE, chronic placental pathologies might be associated with more severe brain injury and needs further study.
Identifiants
pubmed: 35228682
doi: 10.1038/s41372-022-01356-y
pii: 10.1038/s41372-022-01356-y
pmc: PMC9259485
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
885-891Informations de copyright
© 2022. The Author(s).
Références
Douglas-Escobar M, Weiss MD. Hypoxic-ischemic encephalopathy: a review for the clinician. JAMA Pediatr. 2015;169:397–403.
doi: 10.1001/jamapediatrics.2014.3269
Novak CM, Eke AC, Ozen M, Burd I, Graham EM. Risk factors for neonatal hypoxic-ischemic encephalopathy in the absence of sentinel events. Am J Perinatol. 2019;36:27–33.
doi: 10.1055/s-0038-1639356
Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med. 2005;353:1574–84.
doi: 10.1056/NEJMcps050929
Azzopardi DV, Strohm B, Edwards AD, Dyet L, Halliday HL, Juszczak E, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med. 2009;361:1349–58.
doi: 10.1056/NEJMoa0900854
Azzopardi D, Strohm B, Marlow N, Brocklehurst P, Deierl A, Eddama O, et al. Effects of hypothermia for perinatal asphyxia on childhood outcomes. N Engl J Med. 2014;371:140–9.
doi: 10.1056/NEJMoa1315788
Shankaran S, Pappas A, McDonald SA, Vohr BR, Hintz SR, Yolton K, et al. Childhood outcomes after hypothermia for neonatal encephalopathy. N Engl J Med. 2012;366:2085–92.
doi: 10.1056/NEJMoa1112066
de Vries LS, Groenendaal F. Patterns of neonatal hypoxic-ischaemic brain injury. Neuroradiology. 2010;52:555–66.
doi: 10.1007/s00234-010-0674-9
Shankaran S, Laptook AR, McDonald SA, Hintz SR, Barnes PD, Das A, et al. Acute perinatal sentinel events, neonatal brain injury pattern, and outcome of infants undergoing a trial of hypothermia for neonatal hypoxic-ischemic encephalopathy. J Pediatr. 2017;180:275–.e272.
doi: 10.1016/j.jpeds.2016.09.026
Nasiell J, Papadogiannakis N, Lof E, Elofsson F, Hallberg B. Hypoxic ischemic encephalopathy in newborns linked to placental and umbilical cord abnormalities. J Matern Fetal Neonatal Med. 2016;29:721–6.
doi: 10.3109/14767058.2015.1015984
Vik T, Redline R, Nelson KB, Bjellmo S, Vogt C, Ng P, et al. The placenta in neonatal encephalopathy: a case-control study. J Pediatr. 2018;202:77–85.e73.
doi: 10.1016/j.jpeds.2018.06.005
Bingham A, Gundogan F, Rand K, Laptook AR. Placental findings among newborns with hypoxic ischemic encephalopathy. J Perinatol. 2019;39:563–70.
doi: 10.1038/s41372-019-0334-9
Mir IN, Johnson-Welch SF, Nelson DB, Brown LS, Rosenfeld CR, Chalak LF. Placental pathology is associated with severity of neonatal encephalopathy and adverse developmental outcomes following hypothermia. Am J Obstet Gynecol. 2015;213:849.e841–847.
doi: 10.1016/j.ajog.2015.09.072
Hayes BC, Cooley S, Donnelly J, Doherty E, Grehan A, Madigan C, et al. The placenta in infants >36 weeks gestation with neonatal encephalopathy: a case control study. Arch Dis Child Fetal Neonatal Ed. 2013;98:F233–239.
doi: 10.1136/archdischild-2012-301992
Grass B, El Shahed A, Ly LG, Chau V, Branson HM, Blaser S, et al. Therapeutic hypothermia for hypoxic-ischemic encephalopathy after perinatal sentinel events: less brain injury on MRI and improved neurodevelopmental outcome at 18-36 months. J Perinatol. 2020;40:633–9.
doi: 10.1038/s41372-020-0602-8
Harteman JC, Nikkels PG, Benders MJ, Kwee A, Groenendaal F, de Vries LS. Placental pathology in full-term infants with hypoxic-ischemic neonatal encephalopathy and association with magnetic resonance imaging pattern of brain injury. J Pediatr. 2013;163:968–995.e962.
doi: 10.1016/j.jpeds.2013.06.010
Jantzie LL, Robinson S. Placenta and perinatal brain injury: the gateway to individualized therapeutics and precision neonatal medicine. Pediatr Res. 2020;87:807–8.
doi: 10.1038/s41390-020-0807-8
Lachapelle J, Chen M, Oskoui M, Ali N, Brown R, Wintermark P Placental pathology in asphyxiated newborns treated with therapeutic hypothermia. J Neonatal Perinatal Med. 2015;8:33–40.
Brotschi B, Latal B, Rathke V, Hagmann C. National Asphyxia and Cooling Register in Switzerland. Paediatrica; 2014. pp. 11–12.
Hagmann CF, Brotschi B, Bernet V, Latal B, Berger TM, Robertson NJ. Hypothermia for perinatal asphyxial encephalopathy. Swiss Med Wkly. 2011;141:w13145.
pubmed: 21328098
Sarnat HB, Sarnat MS. Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol. 1976;33:696–705.
doi: 10.1001/archneur.1976.00500100030012
Thompson CM, Puterman AS, Linley LL, Hann FM, van der Elst CW, Molteno CD, et al. The value of a scoring system for hypoxic ischaemic encephalopathy in predicting neurodevelopmental outcome. Acta Paediatr. 1997;86:757–61.
doi: 10.1111/j.1651-2227.1997.tb08581.x
Okereafor A, Allsop J, Counsell SJ, Fitzpatrick J, Azzopardi D, Rutherford MA, et al. Patterns of brain injury in neonates exposed to perinatal sentinel events. Pediatrics. 2008;121:906–14.
doi: 10.1542/peds.2007-0770
Kraus FT, Redline RW, Gersell DJ, Nelson DM, Dicke JM Placental Pathology, vol. 3. American registery of pathology: Silver Spring, Maryland, 2005.
Khong TY, Mooney EE, Ariel I, Balmus NC, Boyd TK, Brundler MA, et al. Sampling and Definitions of Placental Lesions: Amsterdam Placental Workshop Group Consensus Statement. Arch Pathol Lab Med. 2016;140:698–713.
doi: 10.5858/arpa.2015-0225-CC
Turowski G, Berge LN, Helgadottir LB, Jacobsen EM, Roald B. A new, clinically oriented, unifying and simple placental classification system. Placenta. 2012;33:1026–35.
doi: 10.1016/j.placenta.2012.10.002
Gunn AJ, Thoresen M. Neonatal encephalopathy and hypoxic-ischemic encephalopathy. Handb Clin Neurol. 2019;162:217–37.
doi: 10.1016/B978-0-444-64029-1.00010-2
Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev. 2013;Cd003311:pp. 3–4.
Thayyil S, Chandrasekaran M, Taylor A, Bainbridge A, Cady EB, Chong WK, et al. Cerebral magnetic resonance biomarkers in neonatal encephalopathy: a meta-analysis. Pediatrics. 2010;125:e382–395.
doi: 10.1542/peds.2009-1046
Weeke LC, Groenendaal F, Mudigonda K, Blennow M, Lequin MH, Meiners LC, et al. A Novel Magnetic Resonance Imaging Score Predicts Neurodevelopmental Outcome After Perinatal Asphyxia and Therapeutic Hypothermia. J Pediatr. 2018;192:e32.
doi: 10.1016/j.jpeds.2017.09.043
Greenfield GJ, Love S Greenfield’s neuropathology, 8th edn. Arnold: London, 2008.
Cordes I, Roland EH, Lupton BA, Hill A. Early prediction of the development of microcephaly after hypoxic-ischemic encephalopathy in the full-term newborn. Pediatrics. 1994;93:703–7.
doi: 10.1542/peds.93.5.703
Mercuri E, Ricci D, Cowan FM, Lessing D, Frisone MF, Haataja L, et al. Head growth in infants with hypoxic-ischemic encephalopathy: correlation with neonatal magnetic resonance imaging. Pediatrics. 2000;106:235–43.
doi: 10.1542/peds.106.2.235
Martinez-Biarge M, Bregant T, Wusthoff CJ, Chew AT, Diez-Sebastian J, Rutherford MA, et al. White matter and cortical injury in hypoxic-ischemic encephalopathy: antecedent factors and 2-year outcome. J Pediatr. 2012;161:799–807.
doi: 10.1016/j.jpeds.2012.04.054
Davis DD, Roshan A, Canela CD, Varacallo M Shoulder Dystocia. StatPearls. StatPearls Publishing Copyright © 2021, StatPearls Publishing LLC.: Treasure Island (FL), 2021.