3D-Printed Micro Lens-in-Lens for In Vivo Multimodal Microendoscopy.
3D printing
multimodal imaging
near infrared fluorescence
optical coherence tomography
two-photon laser lithography
Journal
Small (Weinheim an der Bergstrasse, Germany)
ISSN: 1613-6829
Titre abrégé: Small
Pays: Germany
ID NLM: 101235338
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
revised:
19
01
2022
received:
14
11
2021
pubmed:
2
3
2022
medline:
29
4
2022
entrez:
1
3
2022
Statut:
ppublish
Résumé
Multimodal microendoscopes enable co-located structural and molecular measurements in vivo, thus providing useful insights into the pathological changes associated with disease. However, different optical imaging modalities often have conflicting optical requirements for optimal lens design. For example, a high numerical aperture (NA) lens is needed to realize high-sensitivity fluorescence measurements. In contrast, optical coherence tomography (OCT) demands a low NA to achieve a large depth of focus. These competing requirements present a significant challenge in the design and fabrication of miniaturized imaging probes that are capable of supporting high-quality multiple modalities simultaneously. An optical design is demonstrated which uses two-photon 3D printing to create a miniaturized lens that is simultaneously optimized for these conflicting imaging modalities. The lens-in-lens design contains distinct but connected optical surfaces that separately address the needs of both fluorescence and OCT imaging within a lens of 330 µm diameter. This design shows an improvement in fluorescence sensitivity of >10x in contrast to more conventional fiber-optic design approaches. This lens-in-lens is then integrated into an intravascular catheter probe with a diameter of 520 µm. The first simultaneous intravascular OCT and fluorescence imaging of a mouse artery in vivo is reported.
Identifiants
pubmed: 35229467
doi: 10.1002/smll.202107032
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2107032Subventions
Organisme : European Research Council
Pays : International
Organisme : Wellcome Trust
ID : 105608
Pays : United Kingdom
Informations de copyright
© 2022 The Authors. Small published by Wiley-VCH GmbH.
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