Association of B-type natriuretic peptide with rapid progression in patients with aortic stenosis.
Aortic stenosis
B-type natriuretic peptide
Rapid progression
Transthoracic echocardiogram
Valvular disease
Journal
Reviews in cardiovascular medicine
ISSN: 1530-6550
Titre abrégé: Rev Cardiovasc Med
Pays: Singapore
ID NLM: 100960007
Informations de publication
Date de publication:
22 Feb 2022
22 Feb 2022
Historique:
received:
27
11
2021
revised:
28
12
2021
accepted:
04
01
2022
entrez:
1
3
2022
pubmed:
2
3
2022
medline:
24
3
2022
Statut:
ppublish
Résumé
Rapid progression of aortic stenosis (AS) is associated with poor outcomes, and the impact of B-type natriuretic peptide (BNP) on AS progression remains unknown. The purpose of the present study was to investigate the association between BNP level and the AS progression rate. From January 2016 to June 2021, 200 AS patients with progression who had at least two transthoracic echocardiograms with a maximum interval of 180 days were retrospectively analyzed. Rapid progression of AS was defined as the annual increase of aortic jet velocity (Vmax) ≥0.3 m/s/year. For analyses, both the log-transformed BNP and the BNP ratio were used. The linear regression and binary logistic regression analyses were used to determine the association between BNP and the AS progression. At a median echocardiographic follow-up of 595 days, the annual median (interquartile) progression of Vmax was 0.26 (0.09-0.58) m/s/year. Patients with rapid progression had higher age, log BNP, and higher percentage of diabetes and male gender. Higher tertiles of log BNP and BNP ratio had more rapid increase in Vmax ( Higher BNP was independently associated with the rapid progression of AS.
Sections du résumé
BACKGROUND
BACKGROUND
Rapid progression of aortic stenosis (AS) is associated with poor outcomes, and the impact of B-type natriuretic peptide (BNP) on AS progression remains unknown.
OBJECTIVES
OBJECTIVE
The purpose of the present study was to investigate the association between BNP level and the AS progression rate.
METHODS
METHODS
From January 2016 to June 2021, 200 AS patients with progression who had at least two transthoracic echocardiograms with a maximum interval of 180 days were retrospectively analyzed. Rapid progression of AS was defined as the annual increase of aortic jet velocity (Vmax) ≥0.3 m/s/year. For analyses, both the log-transformed BNP and the BNP ratio were used. The linear regression and binary logistic regression analyses were used to determine the association between BNP and the AS progression.
RESULTS
RESULTS
At a median echocardiographic follow-up of 595 days, the annual median (interquartile) progression of Vmax was 0.26 (0.09-0.58) m/s/year. Patients with rapid progression had higher age, log BNP, and higher percentage of diabetes and male gender. Higher tertiles of log BNP and BNP ratio had more rapid increase in Vmax (
CONCLUSIONS
CONCLUSIONS
Higher BNP was independently associated with the rapid progression of AS.
Identifiants
pubmed: 35229566
pii: S1530-6550(22)00365-9
doi: 10.31083/j.rcm2302075
doi:
Substances chimiques
Biomarkers
0
Natriuretic Peptide, Brain
114471-18-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
75Informations de copyright
© 2022 The Author(s). Published by IMR Press.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.