Cocaine-Induced Changes in Sperm
addiction
epigenetics
intergenerational
self-administration
transgenerational
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
06 04 2022
06 04 2022
Historique:
received:
16
12
2020
revised:
03
01
2022
accepted:
20
01
2022
pubmed:
3
3
2022
medline:
9
4
2022
entrez:
2
3
2022
Statut:
ppublish
Résumé
Paternal environmental perturbations can influence the physiology and behavior of offspring. For example, our previous work showed reduced cocaine reinforcement in male, but not female, progeny of rat sires that self-administered cocaine. The information transfer from sire to progeny may occur through epigenetic marks in sperm, encompassing alterations in small noncoding RNAs, including microRNAs (miRNAs) and/or DNA methylation. Here, no reliable changes in miRNAs in the sperm of cocaine- relative to saline-experienced sires were identified. In contrast, 272 differentially methylated regions were observed in sperm between these groups. Two hypomethylated promoter regions in the sperm of cocaine-experienced rats were upstream of cyclin-dependent kinase inhibitor 1a (
Identifiants
pubmed: 35232758
pii: JNEUROSCI.3172-20.2022
doi: 10.1523/JNEUROSCI.3172-20.2022
pmc: PMC8985859
doi:
Substances chimiques
Cdkn1a protein, rat
0
Cyclin-Dependent Kinase Inhibitor p21
0
MicroRNAs
0
RNA, Messenger
0
Cocaine
I5Y540LHVR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2905-2916Subventions
Organisme : NIDA NIH HHS
ID : DP1 DA046537
Pays : United States
Organisme : NIDA NIH HHS
ID : K01 DA039308
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA033641
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA028874
Pays : United States
Informations de copyright
Copyright © 2022 the authors.
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