CD164 is a host factor for lymphocytic choriomeningitis virus entry.
CD164
arenavirus
lymphocytic choriomeningitis virus
virus entry
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
08 03 2022
08 03 2022
Historique:
entrez:
2
3
2022
pubmed:
3
3
2022
medline:
22
3
2022
Statut:
ppublish
Résumé
Lymphocytic choriomeningitis virus (LCMV) is a rodent-borne zoonotic arenavirus that causes congenital abnormalities and can be fatal for transplant recipients. Using a genome-wide loss-of-function screen, we identify host factors required for LCMV entry into cells. We identify the lysosomal mucin CD164, glycosylation factors, the heparan sulfate biosynthesis machinery, and the known receptor alpha-dystroglycan (α-DG). Biochemical analysis revealed that the LCMV glycoprotein binds CD164 at acidic pH and requires a sialylated glycan at residue N104. We demonstrate that LCMV entry proceeds by the virus switching binding from heparan sulfate or α-DG at the plasma membrane to CD164 prior to membrane fusion, thus identifying additional potential targets for therapeutic intervention.
Identifiants
pubmed: 35235462
doi: 10.1073/pnas.2119676119
pmc: PMC8915965
doi:
Substances chimiques
CD164 protein, human
0
Endolyn
0
Virulence Factors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2119676119Subventions
Organisme : NIAID NIH HHS
ID : F31 AI154700
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007245
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI125179
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI109740
Pays : United States
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