Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium.
DNA methylation
Epigenetics
Mediterranean diet
cord blood
epigenome-wide association study
maternal diet
newborn
prenatal diet
Journal
Epigenetics
ISSN: 1559-2308
Titre abrégé: Epigenetics
Pays: United States
ID NLM: 101265293
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
pubmed:
4
3
2022
medline:
21
10
2022
entrez:
3
3
2022
Statut:
ppublish
Résumé
Higher adherence to the Mediterranean diet during pregnancy is related to a lower risk of preterm birth and to better offspring cardiometabolic health. DNA methylation may be an underlying biological mechanism. We evaluated whether maternal adherence to the Mediterranean diet was associated with offspring cord blood DNA methylation.We meta-analysed epigenome-wide association studies (EWAS) of maternal adherence to the Mediterranean diet during pregnancy and offspring cord blood DNA methylation in 2802 mother-child pairs from five cohorts. We calculated the relative Mediterranean diet (rMED) score with range 0-18 and an adjusted rMED excluding alcohol (rMEDp, range 0-16). DNA methylation was measured using Illumina 450K arrays. We used robust linear regression modelling adjusted for child sex, maternal education, age, smoking, body mass index, energy intake, batch, and cell types. We performed several functional analyses and examined the persistence of differential DNA methylation into childhood (4.5-7.8 y).rMEDp was associated with cord blood DNA methylation at cg23757341 (0.064% increase in DNA methylation per 1-point increase in the rMEDp score, SE = 0.011,
Identifiants
pubmed: 35236238
doi: 10.1080/15592294.2022.2038412
pmc: PMC9586614
doi:
Substances chimiques
Cytosine
8J337D1HZY
Phosphates
0
Guanine
5Z93L87A1R
Types de publication
Meta-Analysis
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1419-1431Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK048520
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD034568
Pays : United States
Organisme : NIEHS NIH HHS
ID : R00 ES025817
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023286
Pays : United States
Organisme : Medical Research Council
ID : MR/S036520/1
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL111108
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK076648
Pays : United States
Organisme : Medical Research Council
ID : MR/S009310/1
Pays : United Kingdom
Organisme : NINR NIH HHS
ID : R01 NR013945
Pays : United States
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