An inhibitor of leukotriene-A

Animals Chiroptera Enzyme Inhibitors / metabolism Epoxide Hydrolases / antagonists & inhibitors Influenza A Virus, H1N1 Subtype / metabolism Leukotriene A4 / metabolism Mice Orthomyxoviridae Infections / enzymology Salivary Glands / enzymology Salivary Proteins and Peptides / metabolism Virus Diseases
Myotis pilosus immunosuppressive salivary gland toxin virus transmission

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
08 03 2022
Historique:
entrez: 3 3 2022
pubmed: 4 3 2022
medline: 16 3 2022
Statut: ppublish

Résumé

SignificanceAn immunosuppressant protein (MTX), which facilitates virus infection by inhibiting leukotriene A

Identifiants

DOI: 10.1073/pnas.2110647119 PMID: 35238649 PMC: PMC8915838
pubmed: 35238649
doi: 10.1073/pnas.2110647119
pmc: PMC8915838
doi:

Substances chimiques

Enzyme Inhibitors 0
Leukotriene A4 0
Salivary Proteins and Peptides 0
Epoxide Hydrolases EC 3.3.2.-
leukotriene A4 hydrolase V38765PUZ6

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2110647119

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Auteurs

Mingqian Fang (M)

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), Institute of Zoology, Kunming 650107, Yunnan, China.

Xiaopeng Tang (X)

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), Institute of Zoology, Kunming 650107, Yunnan, China.
ORCID: 0000-0002-3899-6160

Juan Zhang (J)

Department of Infectious Diseases, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.

Zhiyi Liao (Z)

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), Institute of Zoology, Kunming 650107, Yunnan, China.
Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China.
ORCID: 0000-0003-1998-9763

Gan Wang (G)

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), Institute of Zoology, Kunming 650107, Yunnan, China.
Institutes for Drug Discovery and Development, Chinese Academy of Sciences, Shanghai 201203, China.
Sino-African Joint Research Center, Chinese Academy of Sciences, Wuhan, Hubei 430074, China.
ORCID: 0000-0002-6266-8503

Ruomei Cheng (R)

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), Institute of Zoology, Kunming 650107, Yunnan, China.
Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China.
ORCID: 0000-0002-0580-2964

Zhiye Zhang (Z)

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), Institute of Zoology, Kunming 650107, Yunnan, China.
Institutes for Drug Discovery and Development, Chinese Academy of Sciences, Shanghai 201203, China.
Sino-African Joint Research Center, Chinese Academy of Sciences, Wuhan, Hubei 430074, China.
ORCID: 0000-0002-1661-2277

Hongwen Zhao (H)

Department of Infectious Diseases, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.

Jing Wang (J)

Department of Laboratory Diagnosis, Chongqing Public Health Medical Center, Public Health Hospital of Southwest University, Shapingba District, Chongqing 400038, China.

Zhaoxia Tan (Z)

Department of Infectious Diseases, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.

Peter Muiruri Kamau (PM)

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), Institute of Zoology, Kunming 650107, Yunnan, China.
Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China.
Sino-African Joint Research Center, Chinese Academy of Sciences, Wuhan, Hubei 430074, China.
ORCID: 0000-0002-3874-2777

Qiumin Lu (Q)

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), Institute of Zoology, Kunming 650107, Yunnan, China.
Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China.
Institutes for Drug Discovery and Development, Chinese Academy of Sciences, Shanghai 201203, China.
Sino-African Joint Research Center, Chinese Academy of Sciences, Wuhan, Hubei 430074, China.
ORCID: 0000-0001-9986-9950

Qi Liu (Q)

Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China.

Guohong Deng (G)

Department of Infectious Diseases, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.

Ren Lai (R)

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), Institute of Zoology, Kunming 650107, Yunnan, China.
Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China.
Institutes for Drug Discovery and Development, Chinese Academy of Sciences, Shanghai 201203, China.
Sino-African Joint Research Center, Chinese Academy of Sciences, Wuhan, Hubei 430074, China.
ORCID: 0000-0002-3123-2336

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › An inhibitor of leukotriene-A
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Chiroptera › An inhibitor of leukotriene-A
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › An inhibitor of leukotriene-A
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Epoxide hydrolase › An inhibitor of leukotriene-A
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Orthomyxoviridae › Influenzavirus A › Virus de la grippe A › Sous-type H1N1 du virus de la grippe A › An inhibitor of leukotriene-A
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Leucotriènes › Leucotriène A4 › An inhibitor of leukotriene-A
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › An inhibitor of leukotriene-A
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Orthomyxoviridae › An inhibitor of leukotriene-A
questionsmedicales.fr › Système stomatognathique › Bouche › Glandes salivaires › An inhibitor of leukotriene-A
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides salivaires › An inhibitor of leukotriene-A
questionsmedicales.fr › Infection › Maladies virales › An inhibitor of leukotriene-A