Whole-genome sequencing of

Anti-Infective Agents / therapeutic use Chlamydia Infections / drug therapy Chlamydia trachomatis / genetics Drug Resistance, Bacterial / genetics Humans Mutation Whole Genome Sequencing
Chlamydia antimicrobial genome sequencing treatment failure

Journal

International journal of STD & AIDS
ISSN: 1758-1052
Titre abrégé: Int J STD AIDS
Pays: England
ID NLM: 9007917

Informations de publication

Date de publication:
04 2022
Historique:
pubmed: 4 3 2022
medline: 9 4 2022
entrez: 3 3 2022
Statut: ppublish

Résumé

Current understanding of the causes of treatment failure in Genomic DNA was extracted from Seven isolates from persistently infected patients and five isolates from successfully treated patients were sequenced. No previously reported SNVs associated with antimicrobial resistance were found. A unique SNV was identified in the No genomic evidence was found to explain the differences in clinical outcome for our two groups of patients. A mutation unrelated to antimicrobial susceptibility was found in an isolate from a persistently infected patient. The cause of these persistent infections with

Sections du résumé

BACKGROUND
Current understanding of the causes of treatment failure in
METHODS
Genomic DNA was extracted from
RESULTS
Seven isolates from persistently infected patients and five isolates from successfully treated patients were sequenced. No previously reported SNVs associated with antimicrobial resistance were found. A unique SNV was identified in the
CONCLUSION
No genomic evidence was found to explain the differences in clinical outcome for our two groups of patients. A mutation unrelated to antimicrobial susceptibility was found in an isolate from a persistently infected patient. The cause of these persistent infections with

Identifiants

DOI: 10.1177/09564624211048662 PMID: 35239412
pubmed: 35239412
doi: 10.1177/09564624211048662
doi:

Substances chimiques

Anti-Infective Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

442-446

Auteurs

Rachel Pitt (R)

National Infection Service, Antimicrobial Resistance and Healthcare Associated Infections (AMRHAI), 372064Public Health England, London, UK.
ORCID: 0000-0002-3524-5935

Ronan Doyle (R)

Division of Infection and Immunity, 4919University College London, London, UK.
ORCID: 0000-0001-5001-1945

Mette Theilgaard Christiansen (M)

Division of Infection and Immunity, 4919University College London, London, UK.

Paddy Horner (P)

Population Health Sciences, 1980University of Bristol, Bristol, UK.
Unity Sexual Health, 1984University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
ORCID: 0000-0003-0411-8332

Emma Hathorn (E)

Whittal Street Clinic, 1732University Hospitals Birmingham, Birmingham, UK.

Sarah Alexander (S)

Sexually Transmitted Bacteria Reference Unit, 371011Public Health England, London, UK.

Neil Woodford (N)

National Infection Service, Antimicrobial Resistance and Healthcare Associated Infections (AMRHAI), 372064Public Health England, London, UK.
ORCID: 0000-0003-1396-8953

Michelle Cole (M)

National Infection Service, Antimicrobial Resistance and Healthcare Associated Infections (AMRHAI), 372064Public Health England, London, UK.
ORCID: 0000-0002-6707-6910

Judith Breuer (J)

Division of Infection and Immunity, 4919University College London, London, UK.
ORCID: 0000-0001-8246-0534

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Whole-genome sequencing of
questionsmedicales.fr › Maladies urogénitales › Maladies génitales › Infections à Chlamydia › Whole-genome sequencing of
questionsmedicales.fr › Bactéries › Bactéries à Gram négatif › Chlamydiales › Chlamydiaceae › Chlamydia › Chlamydia trachomatis › Whole-genome sequencing of
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance bactérienne aux médicaments › Whole-genome sequencing of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Whole-genome sequencing of
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Whole-genome sequencing of
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Séquençage du génome entier › Whole-genome sequencing of