Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue.
Dentate gyrus
HCA1 receptor
electrophysiology
epilepsy
human brain slices
Journal
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
pubmed:
5
3
2022
medline:
17
8
2022
entrez:
4
3
2022
Statut:
ppublish
Résumé
Lactate can be used by neurons as an energy substrate to support their activity. Evidence suggests that lactate also acts on a metabotropic receptor called HCAR1, first described in the adipose tissue. Whether HCAR1 also modulates neuronal circuits remains unclear. In this study, using qRT-PCR, we show that HCAR1 is present in the human brain of epileptic patients who underwent resective surgery. In brain slices from these patients, pharmacological HCAR1 activation using a non-metabolized agonist decreased the frequency of both spontaneous neuronal Ca
Identifiants
pubmed: 35240875
doi: 10.1177/0271678X221080324
pmc: PMC9441721
doi:
Substances chimiques
HCAR1 protein, human
0
Hcar1 protein, mouse
0
Receptors, G-Protein-Coupled
0
Lactic Acid
33X04XA5AT
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1650-1665Références
Biochem Biophys Res Commun. 2008 Dec 19;377(3):987-91
pubmed: 18952058
Hippocampus. 2018 Aug;28(8):557-567
pubmed: 29704292
Neuron. 2007 Apr 5;54(1):59-72
pubmed: 17408578
Hippocampus. 1991 Jan;1(1):41-66
pubmed: 1688284
J Neurochem. 1997 Oct;69(4):1484-90
pubmed: 9326277
J Pharmacol Exp Ther. 2012 Jun;341(3):794-801
pubmed: 22434674
Neuroscience. 2006 Aug 11;141(1):157-65
pubmed: 16713114
Neurobiol Learn Mem. 2020 Feb;168:107151
pubmed: 31881352
JCI Insight. 2017 Oct 5;2(19):
pubmed: 28978803
Cereb Cortex. 2005 Apr;15(4):361-70
pubmed: 15749979
Nat Biotechnol. 2014 Jan;32(1):40-51
pubmed: 24406927
Diabetes. 2005 Jan;54(1):15-22
pubmed: 15616006
Hippocampus. 1994 Aug;4(4):393-402
pubmed: 7874231
Physiology (Bethesda). 2017 Nov;32(6):453-463
pubmed: 29021365
PLoS One. 2013 Aug 12;8(8):e71721
pubmed: 23951229
J Cereb Blood Flow Metab. 2002 Mar;22(3):271-9
pubmed: 11891432
Nat Rev Neurosci. 2016 Sep;17(9):562-75
pubmed: 27466143
Cell Metab. 2010 Apr 7;11(4):311-9
pubmed: 20374963
J Cereb Blood Flow Metab. 2002 May;22(5):586-95
pubmed: 11973431
Trends Neurosci. 2002 Mar;25(3):140-4
pubmed: 11852145
Cereb Cortex. 2014 Oct;24(10):2784-95
pubmed: 23696276
Adv Pharmacol. 2011;62:219-50
pubmed: 21907911
Cell. 2011 Mar 4;144(5):810-23
pubmed: 21376239
Nat Rev Neurosci. 2018 Apr;19(4):235-249
pubmed: 29515192
J Neurosci. 2004 Mar 3;24(9):2259-69
pubmed: 14999076
ACS Med Chem Lett. 2012 Jun 11;3(8):637-9
pubmed: 24900524
Front Neuroenergetics. 2012 Mar 19;4:5
pubmed: 22457647
PLoS One. 2020 Nov 12;15(11):e0242309
pubmed: 33180836
Science. 2008 Dec 5;322(5907):1551-5
pubmed: 19056987
Trends Neurosci. 2013 Jul;36(7):396-404
pubmed: 23639382
J Neurosci. 1994 Aug;14(8):5068-76
pubmed: 8046468
Neuron. 2017 Aug 16;95(4):928-943.e3
pubmed: 28817805
Dis Model Mech. 2016 Oct 1;9(10):1079-1087
pubmed: 27736744
Nat Commun. 2014;5:3284
pubmed: 24518663
Hippocampus. 2009 Apr;19(4):321-37
pubmed: 18958849
Science. 2018 Feb 16;359(6377):787-790
pubmed: 29449490
J Neurosci. 2019 Jun 5;39(23):4422-4433
pubmed: 30926749
Neuroscience. 1996 Feb;70(3):631-52
pubmed: 9045077
eNeuro. 2017 Apr 19;4(2):
pubmed: 28451637
Neurobiol Dis. 2015 Sep;81:214-24
pubmed: 25434488
Trends Endocrinol Metab. 2017 Mar;28(3):227-236
pubmed: 28087125
J Cereb Blood Flow Metab. 2015 Oct;35(10):1561-9
pubmed: 26036941
Epilepsia. 2019 Dec;60(12):2370-2385
pubmed: 31755997
J Vis Exp. 2011 Oct 22;(56):
pubmed: 22041662
Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12228-33
pubmed: 25071212
PLoS One. 2011;6(12):e28427
pubmed: 22180782
J Neurochem. 2007 Jul;102(2):466-78
pubmed: 17442042
Neural Netw. 2005 Nov;18(9):1191-201
pubmed: 16233972
J Biol Chem. 2009 Jan 30;284(5):2811-2822
pubmed: 19047060
J Neurosci. 2010 Jun 16;30(24):8061-70
pubmed: 20554857