Selective serotonin reuptake inhibitors and fractures in older nursing home residents: Data from the INCUR study.
Fractures
Frailty
Older people
Osteoporosis
Residents
SSRI
Journal
Maturitas
ISSN: 1873-4111
Titre abrégé: Maturitas
Pays: Ireland
ID NLM: 7807333
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
24
08
2021
revised:
11
11
2021
accepted:
17
11
2021
entrez:
4
3
2022
pubmed:
5
3
2022
medline:
8
3
2022
Statut:
ppublish
Résumé
Depression and selective serotonin reuptake inhibitors (SSRI) reduce bone mass and increase fracture risk. We analyzed the association between SSRI use and fractures development in nursing homes residents during a one-year prospective observational study. Sixty-four of the 800 participants developed a fracture during the one-year follow-up. Individuals who developed fractures used SSRIs more often than residents who did not (40.6% vs 28.7%, p =0.045). SSRIs were associated with fractures (adjusted OR 1.76, 95% CI 1.04 - 2.98, p = 0.036). A regular medication review should be performed to reduce inappropriate prescriptions and related adverse consequences.
Identifiants
pubmed: 35241236
pii: S0378-5122(21)00333-9
doi: 10.1016/j.maturitas.2021.11.012
pii:
doi:
Substances chimiques
Serotonin Uptake Inhibitors
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
37-39Informations de copyright
Copyright © 2021. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.