Autologous NK cells as consolidation therapy following stem cell transplantation in multiple myeloma.


Journal

Cell reports. Medicine
ISSN: 2666-3791
Titre abrégé: Cell Rep Med
Pays: United States
ID NLM: 101766894

Informations de publication

Date de publication:
15 02 2022
Historique:
received: 30 03 2021
revised: 03 11 2021
accepted: 05 01 2022
entrez: 4 3 2022
pubmed: 5 3 2022
medline: 6 5 2022
Statut: epublish

Résumé

Few approaches have been made toward exploring autologous NK cells in settings of cancer immunotherapy. Here, we demonstrate the feasibility of infusing multiple doses of

Identifiants

pubmed: 35243416
doi: 10.1016/j.xcrm.2022.100508
pii: S2666-3791(22)00001-5
pmc: PMC8861830
doi:

Substances chimiques

Granzymes EC 3.4.21.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

100508

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2022 The Authors.

Déclaration de conflit d'intérêts

J. Liwing and P.-H.H. are employed by XNK Therapeutics (XNK); H.N., S.M., and M.C. are consulting for XNK; H.-G.L., is a board member of XNK; M.G., B.S., L.W.-J., K.M., G.G., H.-G.L., and E.A. are minority shareholders of XNK. A patent application pertaining to the use of antiviral prophylaxis in the context of autologous NK cell infusions has been filed (WO 2019/211310 A1). The remaining authors have declared that no competing interests exist.

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Auteurs

Hareth Nahi (H)

Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, Sweden.
Department of Hematology, Karolinska University Hospital, SE-14186 Huddinge, Sweden.

Michael Chrobok (M)

Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, Sweden.

Stephan Meinke (S)

Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, Sweden.

Charlotte Gran (C)

Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, Sweden.
Department of Clinical Chemistry, Karolinska University Laboratory, SE-14183 Huddinge, Sweden.

Nicole Marquardt (N)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, Sweden.

Gabriel Afram (G)

Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, Sweden.
Department of Hematology, Karolinska University Hospital, SE-14186 Huddinge, Sweden.

Tolga Sutlu (T)

Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, Sweden.

Mari Gilljam (M)

Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, Sweden.

Birgitta Stellan (B)

Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, Sweden.

Arnika K Wagner (AK)

Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, Sweden.

Pontus Blomberg (P)

Vecura, Department of Laboratory Medicine, Karolinska Institutet, SE-14186 Stockholm, Sweden.
Vecura, Karolinska Cell Therapy Center, Karolinska University Hospital, SE-14186 Stockholm, Sweden.

Per-Henrik Holmqvist (PH)

Vecura, Karolinska Cell Therapy Center, Karolinska University Hospital, SE-14186 Stockholm, Sweden.

Lilian Walther-Jallow (L)

Department of Clinical Science, Intervention and Technology, Karolinska Institutet, SE-14183 Huddinge, Sweden.

Karin Mellström (K)

XNK Therapeutics AB, Hälsovägen 7, Novum, SE-14157 Huddinge, Sweden.

Johan Liwing (J)

XNK Therapeutics AB, Hälsovägen 7, Novum, SE-14157 Huddinge, Sweden.

Charlotte Gustafsson (C)

Center for Hematology and Regenerative Medicine, Division of Clinical Immunology and Transfusion Medicine, Department of Laboratory Medicine, Karolinska Institutet, SE-14183 Huddinge, Sweden.

Robert Månsson (R)

Center for Hematology and Regenerative Medicine, Division of Clinical Immunology and Transfusion Medicine, Department of Laboratory Medicine, Karolinska Institutet, SE-14183 Huddinge, Sweden.

Monika Klimkowska (M)

Pathology Unit, Department of Laboratory Medicine, Karolinska Institutet, SE-14183 Huddinge, Sweden.
Department of Clinical Pathology and Cytology, Karolinska University Hospital, SE-14186 Huddinge, Sweden.

Gösta Gahrton (G)

Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, Sweden.

Johan Lund (J)

Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, Sweden.
Department of Hematology, Karolinska University Hospital, SE-14186 Huddinge, Sweden.

Per Ljungman (P)

Department of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, SE-14186 Huddinge, Sweden.
Division of Hematology, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, Sweden.

Hans-Gustaf Ljunggren (HG)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, Sweden.

Evren Alici (E)

Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, Sweden.

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