Engineered Living Hydrogels.
engineered living hydrogels
microbe-material interactions
real-world applications
synthetic biology
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
revised:
01
03
2022
received:
09
02
2022
pubmed:
5
3
2022
medline:
6
7
2022
entrez:
4
3
2022
Statut:
ppublish
Résumé
Living biological systems, ranging from single cells to whole organisms, can sense, process information, and actuate in response to changing environmental conditions. Inspired by living biological systems, engineered living cells and nonliving matrices are brought together, which gives rise to the technology of engineered living materials. By designing the functionalities of living cells and the structures of nonliving matrices, engineered living materials can be created to detect variability in the surrounding environment and to adjust their functions accordingly, thereby enabling applications in health monitoring, disease treatment, and environmental remediation. Hydrogels, a class of soft, wet, and biocompatible materials, have been widely used as matrices for engineered living cells, leading to the nascent field of engineered living hydrogels. Here, the interactions between hydrogel matrices and engineered living cells are described, focusing on how hydrogels influence cell behaviors and how cells affect hydrogel properties. The interactions between engineered living hydrogels and their environments, and how these interactions enable versatile applications, are also discussed. Finally, current challenges facing the field of engineered living hydrogels for their applications in clinical and environmental settings are highlighted.
Identifiants
pubmed: 35243704
doi: 10.1002/adma.202201326
pmc: PMC9250645
mid: NIHMS1801949
doi:
Substances chimiques
Biocompatible Materials
0
Hydrogels
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2201326Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL153857
Pays : United States
Organisme : NIH HHS
ID : 1-R01-HL153857-01
Pays : United States
Organisme : Pew Charitable Trusts
ID : 00030623
Organisme : National Science Foundation
ID : EFMA-1935291
Informations de copyright
© 2022 Wiley-VCH GmbH.
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