Electrophysiological characterization of the hyperdirect pathway and its functional relevance for subthalamic deep brain stimulation.
Antidromic activation
High frequency oscillations
Signal-to-noise ratio
Stimulation evoked responses
Journal
Experimental neurology
ISSN: 1090-2430
Titre abrégé: Exp Neurol
Pays: United States
ID NLM: 0370712
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
31
03
2021
revised:
01
02
2022
accepted:
28
02
2022
pubmed:
6
3
2022
medline:
12
4
2022
entrez:
5
3
2022
Statut:
ppublish
Résumé
The subthalamic nucleus (STN) receives input from various cortical areas via hyperdirect pathway (HDP) which bypasses the basal-ganglia loop. Recently, the HDP has gained increasing interest, because of its relevance for STN deep brain stimulation (DBS). To understand the HDP's role cortical responses evoked by STN-DBS have been investigated. These responses have short (<2 ms), medium (2-15 ms), and long (20-70 ms) latencies. Medium-latency responses are supposed to represent antidromic cortical activations via HDP. Together with long-latency responses the medium responses can potentially be used as biomarker of DBS efficacy as well as side effects. We here propose that the activation sequence of the cortical evoked responses can be conceptualized as high frequency oscillations (HFO) for signal analysis. HFO might therefore serve as marker for antidromic activation. Using existing knowledge on HFO recordings, this approach allows data analyses and physiological modeling to advance the pathophysiological understanding of cortical DBS-evoked high-frequency activity.
Identifiants
pubmed: 35247373
pii: S0014-4886(22)00056-5
doi: 10.1016/j.expneurol.2022.114031
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
114031Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.