ASIC1a senses lactate uptake to regulate metabolism in neurons.

Acid Sensing Ion Channels / metabolism Animals Calcium / metabolism Cations, Divalent / metabolism Lactic Acid / metabolism Mice Neurons / metabolism Protons Reactive Oxygen Species / metabolism
ASIC1a Acidification Cytosolic Ca(2+) signaling Cytosolic Na(+) signaling Lactate Mitochondrial Ca(2+) signaling Mitochondrial Na(+) signaling NCLX

Journal

Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639

Informations de publication

Date de publication:
05 2022
Historique:
received: 31 08 2021
revised: 25 01 2022
accepted: 26 01 2022
pubmed: 6 3 2022
medline: 20 4 2022
entrez: 5 3 2022
Statut: ppublish

Résumé

Lactate is a major metabolite largely produced by astrocytes that nourishes neurons. ASIC1a, a Na

Identifiants

DOI: 10.1016/j.redox.2022.102253 PMID: 35247821 PMC: PMC8894274
pubmed: 35247821
pii: S2213-2317(22)00025-8
doi: 10.1016/j.redox.2022.102253
pmc: PMC8894274
pii:
doi:

Substances chimiques

Acid Sensing Ion Channels 0
Cations, Divalent 0
Protons 0
Reactive Oxygen Species 0
Lactic Acid 33X04XA5AT
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102253

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS102452
Pays : United States

Informations de copyright

Copyright © 2022. Published by Elsevier B.V.

Auteurs

Ivana Savic Azoulay (IS)

Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.

Xin Qi (X)

Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Maya Rozenfeld (M)

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.

Fan Liu (F)

Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Qin Hu (Q)

Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Tsipi Ben Kasus Nissim (T)

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.

Alexandra Stavsky (A)

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.

Michael X Zhu (MX)

Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, 77030, USA. Electronic address: Michael.X.Zhu@uth.tmc.edu.

Tian-Le Xu (TL)

Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Center for Brain Science of Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China; Shanghai Research Center for Brain Science and Brain Inspired Intelligence, Shanghai, 201210, China; Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, China. Electronic address: xu-happiness@shsmu.edu.cn.

Israel Sekler (I)

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel. Electronic address: sekler@bgu.ac.il.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Canaux ioniques sensibles à l'acidité › ASIC1a senses lactate uptake to regulate...
questionsmedicales.fr › Eucaryotes › Animaux › ASIC1a senses lactate uptake to regulate...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › ASIC1a senses lactate uptake to regulate...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Cations › Cations divalents › ASIC1a senses lactate uptake to regulate...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Hydroxyacides › Lactates › Acide lactique › ASIC1a senses lactate uptake to regulate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › ASIC1a senses lactate uptake to regulate...
questionsmedicales.fr › Cellules › Neurones › ASIC1a senses lactate uptake to regulate...
questionsmedicales.fr › Phénomènes physiques › Particules élémentaires › Nucléons › Protons › ASIC1a senses lactate uptake to regulate...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › ASIC1a senses lactate uptake to regulate...