Topical ocular drug delivery systems: Innovations for an unmet need.
Drug delivery
Emulsions
Eye drops
Nanoparticles
Ocular drugs
Ocular inserts
Ointments
Pharmacology
Journal
Experimental eye research
ISSN: 1096-0007
Titre abrégé: Exp Eye Res
Pays: England
ID NLM: 0370707
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
30
09
2021
revised:
06
02
2022
accepted:
20
02
2022
pubmed:
7
3
2022
medline:
28
4
2022
entrez:
6
3
2022
Statut:
ppublish
Résumé
The eye is an isolated and complex organ, with multiple robust anatomical and physiological barriers on the ocular surface which protect it from noxious insults such as the blink reflex, tear film and corneoscleral tissue layers. However, these also make it difficult for drugs to reach their therapeutic target within the eye, resulting in very low bioavailability in most commercially available ophthalmic drugs. This review will detail the mechanisms present on the ocular surface which impede drug delivery and give an overview of traditional eye drop formulations, as well as methods of improving their bioavailability through viscosity and permeation enhancement. We also review the evidence for more novel technologies, such as nanoparticles, in-situ gels, blood products, and alternatives to eye drops such as drug loaded contact lenses and ocular inserts.
Identifiants
pubmed: 35248559
pii: S0014-4835(22)00087-2
doi: 10.1016/j.exer.2022.109006
pii:
doi:
Substances chimiques
Ophthalmic Solutions
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
109006Informations de copyright
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