Antioxidant and Antimicrobial Potential, BSA and DNA Binding Properties of Some 3-Hydroxy-3-Pyrrolin-2-Ones Bearing Thenoyl Fragment.
3-hydroxy-3-pyrrolin-2-ones
BSA binding study
DNA binding study
antimicrobial activity
antioxidant activity
biological evaluation
Journal
Medicinal chemistry (Shariqah (United Arab Emirates))
ISSN: 1875-6638
Titre abrégé: Med Chem
Pays: Netherlands
ID NLM: 101240303
Informations de publication
Date de publication:
2022
2022
Historique:
received:
27
07
2021
revised:
09
11
2021
accepted:
10
12
2021
pubmed:
8
3
2022
medline:
18
6
2022
entrez:
7
3
2022
Statut:
ppublish
Résumé
It is known that pyrrolidinone derivates belong to a class of biologically active compounds with a broad spectrum of biological actions. Nowadays, many scientists are making an effort in the discovery of more effective ways to eliminate reactive oxygen species (ROS) that cause oxidative stress or to eliminate the harmful microorganisms from the organism in humans. Therefore, pyrrolidinones seem to be great candidates for the research of this field. The antimicrobial activity of tested compounds was estimated by the determination of the minimal inhibitory concentration by the broth micro-dilution method against four species of bacteria and five species of fungi. The antioxidant activity was evaluated by free radical scavenging and reducing power. Among the tested compounds, P22 showed marked antibacterial activity on Staphylococcus aureus with a MIC value of 0.312 mg/mL. Maximum antifungal activity with MIC value 0.625 mg/mL was shown by P23 and P25 compounds against Trichophyton mentagrophytes. Tested samples showed a relatively strong scavenging activity on DPPH radical (IC Achieved results indicate that our compounds are potential candidates for use as medicaments.
Sections du résumé
BACKGROUND
BACKGROUND
It is known that pyrrolidinone derivates belong to a class of biologically active compounds with a broad spectrum of biological actions. Nowadays, many scientists are making an effort in the discovery of more effective ways to eliminate reactive oxygen species (ROS) that cause oxidative stress or to eliminate the harmful microorganisms from the organism in humans. Therefore, pyrrolidinones seem to be great candidates for the research of this field.
METHODS
METHODS
The antimicrobial activity of tested compounds was estimated by the determination of the minimal inhibitory concentration by the broth micro-dilution method against four species of bacteria and five species of fungi. The antioxidant activity was evaluated by free radical scavenging and reducing power.
RESULTS
RESULTS
Among the tested compounds, P22 showed marked antibacterial activity on Staphylococcus aureus with a MIC value of 0.312 mg/mL. Maximum antifungal activity with MIC value 0.625 mg/mL was shown by P23 and P25 compounds against Trichophyton mentagrophytes. Tested samples showed a relatively strong scavenging activity on DPPH radical (IC
CONCLUSION
CONCLUSIONS
Achieved results indicate that our compounds are potential candidates for use as medicaments.
Identifiants
pubmed: 35249503
pii: MC-EPUB-121377
doi: 10.2174/1573406418666220304230342
doi:
Substances chimiques
Anti-Bacterial Agents
0
Anti-Infective Agents
0
Antioxidants
0
Plant Extracts
0
Pyridinolcarbamate
81R511UV73
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
784-790Subventions
Organisme : Serbian Ministry of Education, Science and Technological Development
ID : 451-03-68/2020-14/200122
Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.