Refractory alopecia universalis associated with dermatomyositis successfully treated with tofacitinib.
Dermatomyositis
alopecia
interferon
janus kinase inhibitor
tofacitinib
Journal
Modern rheumatology case reports
ISSN: 2472-5625
Titre abrégé: Mod Rheumatol Case Rep
Pays: England
ID NLM: 101761026
Informations de publication
Date de publication:
24 06 2022
24 06 2022
Historique:
received:
02
09
2021
revised:
26
10
2021
accepted:
11
02
2022
pubmed:
8
3
2022
medline:
28
6
2022
entrez:
7
3
2022
Statut:
ppublish
Résumé
Dermatomyositis (DM) and alopecia areata are two diseases characterised by aberrant interferon signalling. While patchy alopecia of the scalp is a known feature of DM, alopecia universalis, which involves hair loss over the entire body, has rarely been reported in conjunction with DM. Herein, we report the case of a 30-year-old female with DM who developed refractory cutaneous disease and alopecia universalis that were successfully treated with tofacitinib. This could suggest that concomitant severe alopecia and refractory cutaneous DM may reflect a strong baseline interferon gene signature that may predict responsiveness to janus kinase inhibitors.
Identifiants
pubmed: 35253877
pii: 6543355
doi: 10.1093/mrcr/rxac012
doi:
Substances chimiques
Piperidines
0
Pyrimidines
0
Pyrroles
0
tofacitinib
87LA6FU830
Interferons
9008-11-1
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
199-202Informations de copyright
© Japan College of Rheumatology 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.