CD146 Associates with Gp130 to Control a Macrophage Pro-inflammatory Program That Regulates the Metabolic Response to Obesity.


Journal

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569

Informations de publication

Date de publication:
05 2022
Historique:
revised: 17 02 2022
received: 25 08 2021
pubmed: 9 3 2022
medline: 7 5 2022
entrez: 8 3 2022
Statut: ppublish

Résumé

The mechanism of obesity-related metabolic dysfunction involves the development of systemic inflammation, largely mediated by macrophages. Switching of M1-like adipose tissue macrophages (ATMs) to M2-like ATMs, a population of macrophages associated with weight loss and insulin sensitivity, is considered a viable therapeutic strategy for obesity-related metabolic syndrome. However, mechanisms for reestablishing the polarization of ATMs remain elusive. This study demonstrates that CD146

Identifiants

pubmed: 35258174
doi: 10.1002/advs.202103719
pmc: PMC9069186
doi:

Substances chimiques

CD146 Antigen 0
Il6ra protein, mouse 0
Interleukin-6 0
Receptors, Interleukin-6 0
Cytokine Receptor gp130 133483-10-0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2103719

Subventions

Organisme : Beijing Natural Science Foundation of China
ID : 7192123
Organisme : National Natural Science Foundation of China
ID : 31770793
Organisme : National Natural Science Foundation of China
ID : 82000812
Organisme : Youth Innovation Promotion Association of Chinese Academy of Sciences
ID : 2018122

Informations de copyright

© 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.

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Auteurs

Hongxia Duan (H)

Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

Lin Jing (L)

Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
College of Life Sciences, University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing, 100049, China.

Jianquan Xiang (J)

Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
College of Life Sciences, University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing, 100049, China.

Chenhui Ju (C)

Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

Zhenzhen Wu (Z)

Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

Jingyu Liu (J)

Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
College of Life Sciences, University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing, 100049, China.

Xinran Ma (X)

Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
College of Life Sciences, University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing, 100049, China.

Xuehui Chen (X)

Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

Zheng Liu (Z)

Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

Jing Feng (J)

Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

Xiyun Yan (X)

Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
College of Life Sciences, University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing, 100049, China.
Joint Laboratory of Nanozymes in Zhengzhou University, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China.

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Classifications MeSH