Synaptic inhibition in the lateral habenula shapes reward anticipation.

Animals Calcium Conditioning, Classical / physiology Habenula / physiology Mice Receptors, GABA-A / physiology Reward gamma-Aminobutyric Acid
GABA(A) receptors cue-reward associative behavior lateral habenula synaptic inhibition synaptic plasticity

Journal

Current biology : CB
ISSN: 1879-0445
Titre abrégé: Curr Biol
Pays: England
ID NLM: 9107782

Informations de publication

Date de publication:
25 04 2022
Historique:
received: 08 12 2021
revised: 03 02 2022
accepted: 09 02 2022
pubmed: 9 3 2022
medline: 29 4 2022
entrez: 8 3 2022
Statut: ppublish

Résumé

The lateral habenula (LHb) supports learning processes enabling the prediction of upcoming rewards. While reward-related stimuli decrease the activity of LHb neurons, whether this anchors on synaptic inhibition to guide reward-driven behaviors remains poorly understood. Here, we combine in vivo two-photon calcium imaging with Pavlovian conditioning in mice and report that anticipatory licking emerges along with decreases in cue-evoked calcium signals in individual LHb neurons. In vivo multiunit recordings and pharmacology reveal that the cue-evoked reduction in LHb neuronal firing relies on GABA

Identifiants

DOI: 10.1016/j.cub.2022.02.035 PMID: 35259343
pubmed: 35259343
pii: S0960-9822(22)00257-3
doi: 10.1016/j.cub.2022.02.035
pii:
doi:

Substances chimiques

Receptors, GABA-A 0
gamma-Aminobutyric Acid 56-12-2
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1829-1836.e4

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Arnaud L Lalive (AL)

Department of Fundamental Neuroscience, The University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland.

Mauro Congiu (M)

Department of Fundamental Neuroscience, The University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland.

Christopher Lewis (C)

Brain Research Institute, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

Dominik Groos (D)

Brain Research Institute, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

Joseph A Clerke (JA)

Department of Fundamental Neuroscience, The University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland.

Anna Tchenio (A)

Department of Fundamental Neuroscience, The University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland.

Yuan Ge (Y)

Department of Psychiatry and Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada.

Fritjof Helmchen (F)

Brain Research Institute, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

Manuel Mameli (M)

Department of Fundamental Neuroscience, The University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland; Inserm, UMR-S 839, 17 Rue du Fer À Moulin, 75005 Paris, France. Electronic address: manuel.mameli@unil.ch.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Synaptic inhibition in the lateral habenula...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Synaptic inhibition in the lateral habenula...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Conditionnement (psychologie) › Conditionnement classique › Synaptic inhibition in the lateral habenula...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Épithalamus › Habénula › Synaptic inhibition in the lateral habenula...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Synaptic inhibition in the lateral habenula...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › Récepteurs GABA-A › Synaptic inhibition in the lateral habenula...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Renforcement (psychologie) › Récompense › Synaptic inhibition in the lateral habenula...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Amino-butyrates › Acide gamma-amino-butyrique › Synaptic inhibition in the lateral habenula...