Intranasal oxytocin modulates the salience network in aging.
Aging
Functional connectivity
Independent component analysis
Oxytocin
Resting-state fMRI
Salience network
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
29
10
2021
revised:
25
02
2022
accepted:
28
02
2022
pubmed:
9
3
2022
medline:
26
4
2022
entrez:
8
3
2022
Statut:
ppublish
Résumé
Growing evidence supports a role of the neuropeptide oxytocin in promoting social cognition and prosocial behavior, possibly via modulation of the salience of social information. The effect of intranasal oxytocin administration on the salience network, however, is not well understood, including in the aging brain. To address this research gap, 42 young (22.52 ± 3.02 years; 24 in the oxytocin group) and 43 older (71.12 ± 5.25 years; 21 in the oxytocin group) participants were randomized to either self-administer intranasal oxytocin or placebo prior to resting-state functional imaging. The salience network was identified using independent component analysis (ICA). Independent t-tests showed that individuals in the oxytocin compared to the placebo group had lower within-network resting-state functional connectivity, both for left amygdala (MNI coordinates: x = -18, y = 0, z = -15; corrected p < 0.05) within a more ventral salience network and for right insula (MNI coordinates: x = 39, y = 6, z = -6; corrected p < 0.05) within a more dorsal salience network. Age moderation analysis furthermore demonstrated that the oxytocin-reduced functional connectivity between the ventral salience network and the left amygdala was only present in older participants. These findings suggest a modulatory role of exogenous oxytocin on resting-state functional connectivity within the salience network and support age-differential effects of acute intranasal oxytocin administration on this network.
Identifiants
pubmed: 35259525
pii: S1053-8119(22)00174-4
doi: 10.1016/j.neuroimage.2022.119045
pmc: PMC9450112
mid: NIHMS1830649
pii:
doi:
Substances chimiques
Oxytocin
50-56-6
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
119045Subventions
Organisme : NIA NIH HHS
ID : R01 AG059809
Pays : United States
Organisme : NIA NIH HHS
ID : R24 AG039350
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000064
Pays : United States
Informations de copyright
Copyright © 2022. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no competing financial interests.
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