Neurons detect cognitive boundaries to structure episodic memories in humans.

Cognition Humans Magnetic Resonance Imaging Memory Disorders Memory, Episodic Mental Recall / physiology Neurons Temporal Lobe / physiology

Journal

Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671

Informations de publication

Date de publication:
03 2022
Historique:
received: 01 03 2021
accepted: 19 01 2022
entrez: 9 3 2022
pubmed: 10 3 2022
medline: 7 4 2022
Statut: ppublish

Résumé

While experience is continuous, memories are organized as discrete events. Cognitive boundaries are thought to segment experience and structure memory, but how this process is implemented remains unclear. We recorded the activity of single neurons in the human medial temporal lobe (MTL) during the formation and retrieval of memories with complex narratives. Here, we show that neurons responded to abstract cognitive boundaries between different episodes. Boundary-induced neural state changes during encoding predicted subsequent recognition accuracy but impaired event order memory, mirroring a fundamental behavioral tradeoff between content and time memory. Furthermore, the neural state following boundaries was reinstated during both successful retrieval and false memories. These findings reveal a neuronal substrate for detecting cognitive boundaries that transform experience into mnemonic episodes and structure mental time travel during retrieval.

Identifiants

DOI: 10.1038/s41593-022-01020-w PMID: 35260859 PMC: PMC8966433
pubmed: 35260859
doi: 10.1038/s41593-022-01020-w
pii: 10.1038/s41593-022-01020-w
pmc: PMC8966433
mid: NIHMS1773205
doi:

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

358-368

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH110831
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS103792
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS117839
Pays : United States

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.

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Auteurs

Jie Zheng (J)

Department of Ophthalmology, Children's Hospital, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-9086-3760

Andrea G P Schjetnan (AGP)

Krembil Brain Institute and Division of Neurosurgery, University Health Network (UHN), University of Toronto, Toronto, Ontario, Canada.

Mar Yebra (M)

Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Bernard A Gomes (BA)

Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
ORCID: 0000-0002-2803-964X

Clayton P Mosher (CP)

Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Suneil K Kalia (SK)

Krembil Brain Institute and Division of Neurosurgery, University Health Network (UHN), University of Toronto, Toronto, Ontario, Canada.

Taufik A Valiante (TA)

Krembil Brain Institute and Division of Neurosurgery, University Health Network (UHN), University of Toronto, Toronto, Ontario, Canada.
Department of Surgery (Neurosurgery), Institute of Biomedical Engineering, and Electrical and Computer Engineering, University of Toronto, Toronto, Ontario, Canada.
Max Planck-University of Toronto Center for Neural Science and Technology, University of Toronto, Toronto, Ontario, Canada.
Center for Advancing Neurotechnological Innovation to Application, University Health Network, University of Toronto, Toronto, Ontario, Canada.
ORCID: 0000-0002-3443-3790

Adam N Mamelak (AN)

Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Gabriel Kreiman (G)

Department of Ophthalmology, Children's Hospital, Harvard Medical School, Boston, MA, USA. gabriel.kreiman@childrens.harvard.edu.
Center for Brains, Minds and Machines, Cambridge, MA, USA. gabriel.kreiman@childrens.harvard.edu.
ORCID: 0000-0003-3505-8475

Ueli Rutishauser (U)

Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA. ueli.rutishauser@cshs.org.
Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA. ueli.rutishauser@cshs.org.
Center for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA. ueli.rutishauser@cshs.org.
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. ueli.rutishauser@cshs.org.
ORCID: 0000-0002-9207-7069

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Classifications MeSH

questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Neurons detect cognitive boundaries to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Neurons detect cognitive boundaries to...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Neurons detect cognitive boundaries to...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Manifestations neurocomportementales › Troubles de la mémoire › Neurons detect cognitive boundaries to...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Mémoire › Mémoire épisodique › Neurons detect cognitive boundaries to...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Mémoire › Rappel mnésique › Neurons detect cognitive boundaries to...
questionsmedicales.fr › Cellules › Neurones › Neurons detect cognitive boundaries to...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe temporal › Neurons detect cognitive boundaries to...