A high-resolution view of intra-tumoral B cell immunity.

B-Lymphocytes / pathology Carcinoma, Renal Cell Female Humans Kidney Neoplasms Male Plasma Cells Tertiary Lymphoid Structures / immunology

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
08 03 2022
Historique:
entrez: 9 3 2022
pubmed: 10 3 2022
medline: 6 5 2022
Statut: ppublish

Résumé

In this issue of Immunity, Meylan et al. (2022) uses spatial transcriptomics to examine B cell immunity within intratumoral tertiary lymphoid structures (TLSs). They find that B cells expand and mature into plasma cells (PCs) within the TLS, migrate along fibroblastic tracks to tumor beds, and produce IgG antibodies that target cancer cells.

Identifiants

DOI: 10.1016/j.immuni.2022.02.009 PMID: 35263565
pubmed: 35263565
pii: S1074-7613(22)00089-9
doi: 10.1016/j.immuni.2022.02.009
pii:
doi:

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

387-389

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests X.S.L. is a board member and shareholder of GV20 Oncotherapy and the CEO of its subsidiary, GV20 Therapeutics. X.H. is a shareholder of GV20 Oncotherapy and the Chief Information Officer of its subsidiary, GV20 Therapeutics.

Auteurs

Xihao Hu (X)

GV20 Therapeutics, Cambridge, MA, USA. Electronic address: xihao_hu@gv20therapeutics.com.

X Shirley Liu (XS)

GV20 Therapeutics, Cambridge, MA, USA. Electronic address: xsliu@gv20therapeutics.com.

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Classifications MeSH

questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › A high-resolution view of intra-tumoral B cell...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Tumeurs urologiques › Tumeurs du rein › Néphrocarcinome › A high-resolution view of intra-tumoral B cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A high-resolution view of intra-tumoral B cell...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Tumeurs urologiques › Tumeurs du rein › A high-resolution view of intra-tumoral B cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Plasmocytes › A high-resolution view of intra-tumoral B cell...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Structures lymphoïdes tertiaires › A high-resolution view of intra-tumoral B cell...