Targeting the anti-apoptotic Bcl-2 family proteins: machine learning virtual screening and biological evaluation of new small molecules.

Animals Apoptosis Apoptosis Regulatory Proteins / metabolism Cell Line, Tumor Machine Learning Melanoma Mice Mice, Nude Molecular Docking Simulation Myeloid Cell Leukemia Sequence 1 Protein
Bcl-2 family Bcl-2 family inhibitors apoptosis autophagy virtual screening

Journal

Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395

Informations de publication

Date de publication:
2022
Historique:
received: 24 06 2021
accepted: 05 11 2021
entrez: 10 3 2022
pubmed: 11 3 2022
medline: 22 4 2022
Statut: epublish

Résumé

Bcl-2 family anti-apoptotic proteins are overexpressed in several hematological and solid tumors, and contribute to tumor formation, progression, and resistance to therapy. They represent a promising therapeutic avenue to explore for cancer treatment. Venetoclax, a Bcl-2 inhibitor is currently used for hematological malignancies or is undergoing clinical trials for either hematological or solid tumors. Despite these progresses, ongoing efforts are focusing on the identification and development of new molecules targeting Bcl-2 protein and/or other family members.

Identifiants

DOI: 10.7150/thno.64233 PMID: 35265218 PMC: PMC8899577
pubmed: 35265218
doi: 10.7150/thno.64233
pii: thnov12p2427
pmc: PMC8899577
doi:

Substances chimiques

Apoptosis Regulatory Proteins 0
Myeloid Cell Leukemia Sequence 1 Protein 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2427-2444

Informations de copyright

© The author(s).

Déclaration de conflit d'intérêts

Competing Interests: The authors have declared that no competing interest exists.

Références

Cell Death Dis. 2016 Dec 1;7(12):e2492
pubmed: 27906188
ChemMedChem. 2011 Oct 4;6(10):1797-805
pubmed: 21805647
Cell Death Differ. 2021 Mar;28(3):1130-1132
pubmed: 33469228
Oncotarget. 2016 Mar 8;7(10):11332-48
pubmed: 26870991
Cell Death Dis. 2017 Jul 20;8(7):e2950
pubmed: 28726784
Cancers (Basel). 2021 Jun 14;13(12):
pubmed: 34198580
Curr Opin Chem Biol. 2017 Aug;39:133-142
pubmed: 28735187
J Chem Inf Model. 2014 Mar 24;54(3):956-69
pubmed: 24564321
Cell Death Differ. 2011 Jun;18(6):1024-35
pubmed: 21233846
Clin Transl Med. 2013 Jan 17;2(1):3
pubmed: 23369605
Neoplasia. 2007 Nov;9(11):882-92
pubmed: 18030356
J Neurochem. 2008 Nov;107(3):871-82
pubmed: 18786178
Cell Death Differ. 2020 Mar;27(3):843-857
pubmed: 31836831
Mol Biol Cell. 2005 Sep;16(9):4153-62
pubmed: 15987743
J Chem Inf Model. 2014 Mar 24;54(3):970-7
pubmed: 24555544
Autophagy. 2019 May;15(5):785-795
pubmed: 30626284
Cancer Cell. 2015 Jun 8;27(6):852-63
pubmed: 26004684
Oncogenesis. 2020 Feb 14;9(2):22
pubmed: 32060259
Nat Med. 2013 Feb;19(2):202-8
pubmed: 23291630
Cell Death Dis. 2018 Jan 18;9(2):29
pubmed: 29348439
J Immunother Cancer. 2020 Apr;8(1):
pubmed: 32269145
Lancet Oncol. 2010 Dec;11(12):1149-59
pubmed: 21094089
Nat Commun. 2019 Jun 3;10(1):2385
pubmed: 31160589
Melanoma Res. 2014 Jun;24(3):237-43
pubmed: 24667300
Bioorg Med Chem. 2018 Jan 15;26(2):443-454
pubmed: 29229225
Cell Death Differ. 2017 Aug;24(8):1348-1358
pubmed: 28234359
Oncoscience. 2018 Aug 14;5(7-8):218-219
pubmed: 30234143
Carcinogenesis. 2013 Nov;34(11):2558-67
pubmed: 23836782
Cell Death Differ. 2018 Jan;25(1):65-80
pubmed: 29149100
Cell Death Dis. 2020 Oct 15;11(10):861
pubmed: 33060591
J Cell Physiol. 2005 Dec;205(3):414-21
pubmed: 15920759
J Cheminform. 2019 Aug 9;11(1):56
pubmed: 31399858
Cancers (Basel). 2019 May 17;11(5):
pubmed: 31108964
Front Pharmacol. 2018 Nov 13;9:1275
pubmed: 30524275
Cancer Cell. 2018 Dec 10;34(6):879-891
pubmed: 30537511
Nat Commun. 2017 Jul 17;8:16078
pubmed: 28714472
Mol Carcinog. 2016 Dec;55(12):2304-2312
pubmed: 26599548
Drugs Context. 2019 Oct 09;8:212574
pubmed: 31645879
Carcinogenesis. 2017 Jun 1;38(6):579-587
pubmed: 28203756
Invest New Drugs. 2020 Jun;38(3):675-689
pubmed: 31264066
Mol Cancer Res. 2007 Aug;5(8):761-71
pubmed: 17699103
Nat Commun. 2016 Jan 20;7:10384
pubmed: 26785948
Nucleic Acids Res. 2012 Jan;40(Database issue):D1100-7
pubmed: 21948594
Drug Discov Today. 2016 Jun;21(6):989-96
pubmed: 26631752
Int J Cancer. 2018 Feb 1;142(3):584-596
pubmed: 28949016
Cell Death Differ. 2007 May;14(5):943-51
pubmed: 17205078
Neoplasia. 2013 Mar;15(3):315-27
pubmed: 23479509
PLoS One. 2016 Mar 03;11(3):e0149353
pubmed: 26938720
J Exp Clin Cancer Res. 2018 Nov 19;37(1):278
pubmed: 30454024
Cell Death Dis. 2017 Dec 13;8(12):3216
pubmed: 29238043
Cell Death Differ. 2018 Jan;25(1):27-36
pubmed: 29099483
J Biol Chem. 2008 Dec 12;283(50):34712-9
pubmed: 18936097
Cell Death Dis. 2016 Feb 11;7:e2090
pubmed: 26866271
PLoS One. 2010 Jul 27;5(7):e11772
pubmed: 20668552
Cancer Res. 2017 Jul 1;77(13):3513-3526
pubmed: 28522750

Auteurs

Elisabetta Valentini (E)

Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome, Italy.

Simona D'Aguanno (S)

Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome, Italy.

Marta Di Martile (M)

Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome, Italy.

Camilla Montesano (C)

Department of Chemistry, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, Italy.

Virginia Ferraresi (V)

Sarcomas and Rare Tumours Departmental Unit- IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome, Italy.

Alexandros Patsilinakos (A)

Rome Center for Molecular Design, Department of Drug Chemistry and Technology, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, Italy.
Department of Drug Chemistry, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, Italy.

Manuela Sabatino (M)

Rome Center for Molecular Design, Department of Drug Chemistry and Technology, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, Italy.
Department of Drug Chemistry, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, Italy.

Lorenzo Antonini (L)

Rome Center for Molecular Design, Department of Drug Chemistry and Technology, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, Italy.
Department of Drug Chemistry, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, Italy.

Martina Chiacchiarini (M)

Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome, Italy.

Sergio Valente (S)

Department of Drug Chemistry, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, Italy.

Antonello Mai (A)

Department of Drug Chemistry, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, Italy.
Pasteur Institute, Cenci Bolognetti Foundation, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, Italy.

Gianni Colotti (G)

Institute of Molecular Biology and Pathology, Italian National Research Council, Piazzale A.Moro 5, 20 Rome, Italy.

Rino Ragno (R)

Rome Center for Molecular Design, Department of Drug Chemistry and Technology, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, Italy.
Department of Drug Chemistry, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, Italy.

Daniela Trisciuoglio (D)

Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome, Italy.
Institute of Molecular Biology and Pathology, Italian National Research Council, Piazzale A.Moro 5, 20 Rome, Italy.

Donatella Del Bufalo (D)

Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome, Italy.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Targeting the anti-apoptotic Bcl-2 family...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Targeting the anti-apoptotic Bcl-2 family...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Targeting the anti-apoptotic Bcl-2 family...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Targeting the anti-apoptotic Bcl-2 family...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Algorithmes › Intelligence artificielle › Apprentissage machine › Targeting the anti-apoptotic Bcl-2 family...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › Targeting the anti-apoptotic Bcl-2 family...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Targeting the anti-apoptotic Bcl-2 family...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris nude › Targeting the anti-apoptotic Bcl-2 family...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Targeting the anti-apoptotic Bcl-2 family...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-bcl-2 › Protéine Mcl-1 › Targeting the anti-apoptotic Bcl-2 family...