Gianni Colotti

Affiliations

Istituto di Biologia e Patologia Molecolari del CNR c/o Dipartimento di Scienze Biochimiche, Sapienza Università di Roma, Roma, Italy.

Publications (29)

Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme.

PLoS neglected tropical diseases

Avec: Lorenzo Turcano , Theo Battista , Esther Torrente De Haro , Antonino Missineo , Cristina Alli , Giacomo Paonessa , Gianni Colotti , Steven Harper , Annarita Fiorillo , Andrea Ilari , Alberto Bresciani

Huntingtin Ubiquitination Mechanisms and Novel Possible Therapies to Decrease the Toxic Effects of Mutated Huntingtin.

Journal of personalized medicine

Avec: Annarita Fiorillo , Veronica Morea , Gianni Colotti , Andrea Ilari

ERp57 chaperon protein protects neuronal cells from Aβ-induced toxicity.

Journal of neurochemistry

Avec: Daniel Di Risola , Daniela Ricci , Ilaria Marrocco , Flavia Giamogante , Maddalena Grieco , Antonio Francioso , Aldrin Vasco-Vidal , Patrizia Mancini , Gianni Colotti , Luciana Mosca , Fabio Altieri

Sorcin is an early marker of neurodegeneration, Ca

Cell death & disease

Avec: Ilaria Genovese , Flavia Giamogante , Lucia Barazzuol , Theo Battista , Annarita Fiorillo , Mattia Vicario , Giuseppina D'Alessandro , Raffaela Cipriani , Cristina Limatola , Daniela Rossi , Vincenzo Sorrentino , Elena Poser , Luciana Mosca , Ferdinando Squitieri , Marzia Perluigi , Andrea Arena , Filip van Petegem , Claudia Tito , Francesco Fazi , Carlotta Giorgi , Tito Calì , Andrea Ilari , Gianni Colotti

Bioinformatics analysis of Ras homologue enriched in the striatum, a potential target for Huntington's disease therapy.

International journal of molecular medicine

Avec: Miriam Carbo , Valentina Brandi , Gianmarco Pascarella , David Sasah Staid , Gianni Colotti , Fabio Polticelli , Andrea Ilari , Veronica Morea

NMR structure of a non-conjugatable, ADP-ribosylation associated, ubiquitin-like domain from Tetrahymena thermophila polyubiquitin locus.

Biochimica et biophysica acta. General subjects

Avec: Valerio Chiarini , Helena Tossavainen , Vivek Sharma , Gianni Colotti

Roles of Sorcin in Drug Resistance in Cancer: One Protein, Many Mechanisms, for a Novel Potential Anticancer Drug Target.

Cancers

Avec: Theo Battista , Annarita Fiorillo , Valerio Chiarini , Ilaria Genovese , Andrea Ilari , Gianni Colotti

Inhibition of

Molecules (Basel, Switzerland)

Avec: Valentina Noemi Madia , Davide Ialongo , Elisa Patacchini , Cécile Exertier , Lorenzo Antonelli , Gianni Colotti , Antonella Messore , Valeria Tudino , Francesco Saccoliti , Luigi Scipione , Andrea Ilari , Roberta Costi , Roberto Di Santo

Investigation of the Entry Pathway and Molecular Nature of σ1 Receptor Ligands.

International journal of molecular sciences

Avec: Gianmarco Pascarella , Lorenzo Antonelli , Daniele Narzi , Theo Battista , Annarita Fiorillo , Gianni Colotti , Leonardo Guidoni , Veronica Morea , Andrea Ilari

Widespread in vivo efficacy of The-0504: A conditionally-activatable nanoferritin for tumor-agnostic targeting of CD71-expressing cancers.

Heliyon

Avec: Giulio Fracasso , Elisabetta Falvo , Giada Tisci , Gianluca Sala , Gianni Colotti , Sara Cingarlini , Claudia Tito , Sandra Bibbo , Cristina Frusteri , Elisa Tremante , Elena Giordani , Patrizio Giacomini , Pierpaolo Ceci

Nose-to-brain selective drug delivery to glioma via ferritin-based nanovectors reduces tumor growth and improves survival rate.

Cell death & disease

Avec: Francesco Marrocco , Elisabetta Falvo , Luciana Mosca , Giada Tisci , Alessandro Arcovito , Alice Reccagni , Cristina Limatola , Roberta Bernardini , Pierpaolo Ceci , Giuseppina D'Alessandro , Gianni Colotti

Profiling calcium-dependent interactions between Sorcin and intrinsically disordered regions of human proteome.

Biochimica et biophysica acta. General subjects

Avec: Ilaria Genovese , Andrea Carotti , Andrea Ilari , Annarita Fiorillo , Theo Battista , Gianni Colotti , Ylva Ivarsson

Isolation and preliminary characterization of a human 'phage display'-derived antibody against neural adhesion molecule-1 antigen interfering with fibroblast growth factor receptor-1 binding.

Human antibodies

Avec: Michela Flego , Gianni Colotti , Alessandro Ascione , Maria Luisa Dupuis , Eleonora Petrucci , Roberta Riccioni , Mauro Andreotti , Carla Raggi , Alessandra Boe , Stefano Barca , Mara Gellini , Stefano Vella , Alessandra Mallano

Structural basis of ubiquitination mediated by protein splicing in early Eukarya.

Biochimica et biophysica acta. General subjects

Avec: Valerio Chiarini , Annarita Fiorillo , Serena Camerini , Marco Crescenzi , Shin Nakamura , Theo Battista , Leonardo Guidoni , Gianni Colotti , Andrea Ilari

Known Drugs Identified by Structure-Based Virtual Screening Are Able to Bind Sigma-1 Receptor and Increase Growth of Huntington Disease Patient-Derived Cells.

International journal of molecular sciences

Avec: Theo Battista , Gianmarco Pascarella , David Sasah Staid , Gianni Colotti , Jessica Rosati , Annarita Fiorillo , Alessia Casamassa , Angelo Luigi Vescovi , Barbara Giabbai , Marta Stefania Semrau , Sergio Fanelli , Paola Storici , Ferdinando Squitieri , Veronica Morea , Andrea Ilari

Neuropilin-1 is required for endothelial cell adhesion to soluble vascular endothelial growth factor receptor 1.

The FEBS journal

Avec: Gianni Colotti , Cristina Maria Failla , Pedro Miguel Lacal , Mariangela Ungarelli , Federica Ruffini , Patrizio Di Micco , Angela Orecchia , Veronica Morea

Targeting the anti-apoptotic Bcl-2 family proteins: machine learning virtual screening and biological evaluation of new small molecules.

Theranostics

Avec: Elisabetta Valentini , Simona D'Aguanno , Marta Di Martile , Camilla Montesano , Virginia Ferraresi , Alexandros Patsilinakos , Manuela Sabatino , Lorenzo Antonini , Martina Chiacchiarini , Sergio Valente , Antonello Mai , Gianni Colotti , Rino Ragno , Daniela Trisciuoglio , Donatella Del Bufalo

Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases.

Molecules (Basel, Switzerland)

Avec: Theo Battista , Gianni Colotti , Andrea Ilari , Annarita Fiorillo

Exogenous peptides are able to penetrate human cell and mitochondrial membranes, stabilize mitochondrial tRNA structures, and rescue severe mitochondrial defects.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Elena Perli , Annalinda Pisano , Maria Gemma Pignataro , Antonio Francesco Campese , Maria Pelullo , Ilaria Genovese , Valeria de Turris , Anna Maria Ghelli , Bruna Cerbelli , Carla Giordano , Gianni Colotti , Veronica Morea , Giulia d'Amati

Structure-guided approach to identify a novel class of anti-leishmaniasis diaryl sulfide compounds targeting the trypanothione metabolism.

Amino acids

Avec: Gianni Colotti , Francesco Saccoliti , Marina Gramiccia , Trentina Di Muccio , Jay Prakash , Sunita Yadav , Vikash Kumar Dubey , Giulio Vistoli , Theo Battista , Stefano Mocci , Annarita Fiorillo , Aasia Bibi , Valentina Noemi Madia , Antonella Messore , Roberta Costi , Roberto Di Santo , Andrea Ilari

Doxorubicin and other anthracyclines in cancers: Activity, chemoresistance and its overcoming.

Molecular aspects of medicine

Avec: Roberto Mattioli , Andrea Ilari , Beatrice Colotti , Luciana Mosca , Francesco Fazi , Gianni Colotti

Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells.

Journal of medicinal chemistry

Avec: Clemens Zwergel , Michele Aventaggiato , Sabrina Garbo , Elisabetta Di Bello , Bruno Fassari , Beatrice Noce , Carola Castiello , Chiara Lambona , Federica Barreca , Dante Rotili , Rossella Fioravanti , Thomas Schmalz , Michael Weyand , Amelie Niedermeier , Marco Tripodi , Gianni Colotti , Clemens Steegborn , Cecilia Battistelli , Marco Tafani , Sergio Valente , Antonello Mai

Discovery of the First Human Arylsulfatase A Reversible Inhibitor Impairing Mouse Oocyte Fertilization.

ACS chemical biology

Avec: Silvia Caroselli , Clemens Zwergel , Adele Pirolli , Manuela Sabatino , Zhanjie Xu , Gilbert Kirsch , Antonello Mai , Gianni Colotti , Fabio Altieri , Rita Canipari , Sergio Valente , Rino Ragno

Taxanes in cancer treatment: Activity, chemoresistance and its overcoming.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

Avec: Luciana Mosca , Andrea Ilari , Francesco Fazi , Yehuda G Assaraf , Gianni Colotti

Innovative Approach for a Classic Target: Fragment Screening on Trypanothione Reductase Reveals New Opportunities for Drug Design.

Frontiers in molecular biosciences

Avec: Annarita Fiorillo , Gianni Colotti , Cécile Exertier , Anastasia Liuzzi , Francesca Seghetti , Alessandra Salerno , Jessica Caciolla , Andrea Ilari

Characterization of the Escherichia coli pyridoxal 5'-phosphate homeostasis protein (YggS): Role of lysine residues in PLP binding and protein stability.

Protein science : a publication of the Protein Society

Avec: Angela Tramonti , Mohini S Ghatge , Jill T Babor , Faik N Musayev , Martino Luigi di Salvo , Anna Barile , Gianni Colotti , Alessandra Giorgi , Steven D Paredes , Akua K Donkor , Mohammed H Al Mughram , Valérie de Crécy-Lagard , Martin K Safo , Roberto Contestabile

Sorcin promotes migration in cancer and regulates the EGF-dependent EGFR signaling pathways.

Cellular and molecular life sciences : CMLS

Avec: Claudia Tito , Ilaria Genovese , Flavia Giamogante , Anna Benedetti , Selenia Miglietta , Lucia Barazzuol , Loredana Cristiano , Alessia Iaiza , Sabatino Carolini , Luciana De Angelis , Silvia Masciarelli , Stefania Annarita Nottola , Giuseppe Familiari , Vincenzo Petrozza , Mattia Lauriola , Luca Tamagnone , Andrea Ilari , Tito Calì , Hector H Valdivia , Carmen R Valdivia , Gianni Colotti , Francesco Fazi

Bcl-2 family inhibitors sensitize human cancer models to therapy.

Cell death & disease

Avec: Elisabetta Valentini , Marta Di Martile , Matteo Brignone , Marica Di Caprio , Isabella Manni , Michela Chiappa , Ilaria Sergio , Martina Chiacchiarini , Chiara Bazzichetto , Fabiana Conciatori , Simona D'Aguanno , Carmen D'Angelo , Rino Ragno , Michelangelo Russillo , Gianni Colotti , Francesco Marchesi , Maria Laura Bellone , Fabrizio Dal Piaz , Maria Pia Felli , Giovanna Damia , Donatella Del Bufalo

Sorcin in Cancer Development and Chemotherapeutic Drug Resistance.

Cancers

Avec: Cécile Exertier , Lorenzo Antonelli , Annarita Fiorillo , Roberta Bernardini , Beatrice Colotti , Andrea Ilari , Gianni Colotti

Réseau de co-auteurs

Andrea Ilari 17 collaborations

Annarita Fiorillo 12 collaborations

Theo Battista 9 collaborations

Veronica Morea 6 collaborations

Luciana Mosca 5 collaborations

Ilaria Genovese 5 collaborations

Francesco Fazi 4 collaborations

Flavia Giamogante 3 collaborations

Claudia Tito 3 collaborations

Gianmarco Pascarella 3 collaborations

Valerio Chiarini 3 collaborations

Cécile Exertier 3 collaborations

Lorenzo Antonelli 3 collaborations

Sergio Valente 3 collaborations

Antonello Mai 3 collaborations

Rino Ragno 3 collaborations

Fabio Altieri 2 collaborations

Lucia Barazzuol 2 collaborations

Giuseppina D'Alessandro 2 collaborations

Cristina Limatola 2 collaborations

Ferdinando Squitieri 2 collaborations

Tito Calì 2 collaborations

David Sasah Staid 2 collaborations

Valentina Noemi Madia 2 collaborations

Antonella Messore 2 collaborations

Francesco Saccoliti 2 collaborations

Roberta Costi 2 collaborations

Roberto Di Santo 2 collaborations

Leonardo Guidoni 2 collaborations

Elisabetta Falvo 2 collaborations

Giada Tisci 2 collaborations

Pierpaolo Ceci 2 collaborations

Roberta Bernardini 2 collaborations

Elisabetta Valentini 2 collaborations

Simona D'Aguanno 2 collaborations

Marta Di Martile 2 collaborations

Manuela Sabatino 2 collaborations

Martina Chiacchiarini 2 collaborations

Donatella Del Bufalo 2 collaborations

Beatrice Colotti 2 collaborations

Clemens Zwergel 2 collaborations

Lorenzo Turcano 1 collaboration

Esther Torrente De Haro 1 collaboration

Antonino Missineo 1 collaboration

Cristina Alli 1 collaboration

Giacomo Paonessa 1 collaboration

Steven Harper 1 collaboration

Alberto Bresciani 1 collaboration

Daniel Di Risola 1 collaboration

Daniela Ricci 1 collaboration

Ilaria Marrocco 1 collaboration

Maddalena Grieco 1 collaboration

Antonio Francioso 1 collaboration

Aldrin Vasco-Vidal 1 collaboration

Patrizia Mancini 1 collaboration

Mattia Vicario 1 collaboration

Raffaela Cipriani 1 collaboration

Daniela Rossi 1 collaboration

Vincenzo Sorrentino 1 collaboration

Elena Poser 1 collaboration

Marzia Perluigi 1 collaboration

Andrea Arena 1 collaboration

Filip van Petegem 1 collaboration

Carlotta Giorgi 1 collaboration

Miriam Carbo 1 collaboration

Valentina Brandi 1 collaboration

Fabio Polticelli 1 collaboration

Helena Tossavainen 1 collaboration

Vivek Sharma 1 collaboration

Davide Ialongo 1 collaboration

Elisa Patacchini 1 collaboration

Valeria Tudino 1 collaboration

Luigi Scipione 1 collaboration

Daniele Narzi 1 collaboration

Giulio Fracasso 1 collaboration

Gianluca Sala 1 collaboration

Sara Cingarlini 1 collaboration

Sandra Bibbo 1 collaboration

Cristina Frusteri 1 collaboration

Elisa Tremante 1 collaboration

Elena Giordani 1 collaboration

Patrizio Giacomini 1 collaboration

Francesco Marrocco 1 collaboration

Alessandro Arcovito 1 collaboration

Alice Reccagni 1 collaboration

Andrea Carotti 1 collaboration

Ylva Ivarsson 1 collaboration

Michela Flego 1 collaboration

Alessandro Ascione 1 collaboration

Maria Luisa Dupuis 1 collaboration

Eleonora Petrucci 1 collaboration

Roberta Riccioni 1 collaboration

Mauro Andreotti 1 collaboration

Carla Raggi 1 collaboration

Alessandra Boe 1 collaboration

Stefano Barca 1 collaboration

Mara Gellini 1 collaboration

Stefano Vella 1 collaboration

Alessandra Mallano 1 collaboration

Serena Camerini 1 collaboration

Marco Crescenzi 1 collaboration

Shin Nakamura 1 collaboration

Jessica Rosati 1 collaboration

Alessia Casamassa 1 collaboration

Angelo Luigi Vescovi 1 collaboration

Barbara Giabbai 1 collaboration

Marta Stefania Semrau 1 collaboration

Sergio Fanelli 1 collaboration

Paola Storici 1 collaboration

Cristina Maria Failla 1 collaboration

Pedro Miguel Lacal 1 collaboration

Mariangela Ungarelli 1 collaboration

Federica Ruffini 1 collaboration

Patrizio Di Micco 1 collaboration

Angela Orecchia 1 collaboration

Camilla Montesano 1 collaboration

Virginia Ferraresi 1 collaboration

Alexandros Patsilinakos 1 collaboration

Lorenzo Antonini 1 collaboration

Daniela Trisciuoglio 1 collaboration

Elena Perli 1 collaboration

Annalinda Pisano 1 collaboration

Maria Gemma Pignataro 1 collaboration

Antonio Francesco Campese 1 collaboration

Maria Pelullo 1 collaboration

Valeria de Turris 1 collaboration

Anna Maria Ghelli 1 collaboration

Bruna Cerbelli 1 collaboration

Carla Giordano 1 collaboration

Giulia d'Amati 1 collaboration

Marina Gramiccia 1 collaboration

Trentina Di Muccio 1 collaboration

Jay Prakash 1 collaboration

Sunita Yadav 1 collaboration

Vikash Kumar Dubey 1 collaboration

Giulio Vistoli 1 collaboration

Stefano Mocci 1 collaboration

Aasia Bibi 1 collaboration

Roberto Mattioli 1 collaboration

Michele Aventaggiato 1 collaboration

Sabrina Garbo 1 collaboration

Elisabetta Di Bello 1 collaboration

Bruno Fassari 1 collaboration

Beatrice Noce 1 collaboration

Carola Castiello 1 collaboration

Chiara Lambona 1 collaboration

Federica Barreca 1 collaboration

Dante Rotili 1 collaboration

Rossella Fioravanti 1 collaboration

Thomas Schmalz 1 collaboration

Michael Weyand 1 collaboration

Amelie Niedermeier 1 collaboration

Marco Tripodi 1 collaboration

Clemens Steegborn 1 collaboration

Cecilia Battistelli 1 collaboration

Marco Tafani 1 collaboration

Silvia Caroselli 1 collaboration

Adele Pirolli 1 collaboration

Zhanjie Xu 1 collaboration

Gilbert Kirsch 1 collaboration

Rita Canipari 1 collaboration

Yehuda G Assaraf 1 collaboration

Anastasia Liuzzi 1 collaboration

Francesca Seghetti 1 collaboration

Alessandra Salerno 1 collaboration

Jessica Caciolla 1 collaboration

Angela Tramonti 1 collaboration

Mohini S Ghatge 1 collaboration

Jill T Babor 1 collaboration

Faik N Musayev 1 collaboration

Martino Luigi di Salvo 1 collaboration

Anna Barile 1 collaboration

Alessandra Giorgi 1 collaboration

Steven D Paredes 1 collaboration

Akua K Donkor 1 collaboration

Mohammed H Al Mughram 1 collaboration

Valérie de Crécy-Lagard 1 collaboration

Martin K Safo 1 collaboration

Roberto Contestabile 1 collaboration

Anna Benedetti 1 collaboration

Selenia Miglietta 1 collaboration

Loredana Cristiano 1 collaboration

Alessia Iaiza 1 collaboration

Sabatino Carolini 1 collaboration

Luciana De Angelis 1 collaboration

Silvia Masciarelli 1 collaboration

Stefania Annarita Nottola 1 collaboration

Giuseppe Familiari 1 collaboration

Vincenzo Petrozza 1 collaboration

Mattia Lauriola 1 collaboration

Luca Tamagnone 1 collaboration

Hector H Valdivia 1 collaboration

Carmen R Valdivia 1 collaboration

Matteo Brignone 1 collaboration

Marica Di Caprio 1 collaboration

Isabella Manni 1 collaboration

Michela Chiappa 1 collaboration

Ilaria Sergio 1 collaboration

Chiara Bazzichetto 1 collaboration

Fabiana Conciatori 1 collaboration

Carmen D'Angelo 1 collaboration

Michelangelo Russillo 1 collaboration

Francesco Marchesi 1 collaboration

Maria Laura Bellone 1 collaboration

Fabrizio Dal Piaz 1 collaboration

Maria Pia Felli 1 collaboration

Giovanna Damia 1 collaboration