Roberto Contestabile

Affiliations

Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, Rome, Italy. roberto.contestabile@uniroma1.it.

Publications (33)

Molecular characterization of pyridoxine 5'-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy.

Scientific reports

Avec: Anna Barile , Isabel Nogués , Martino L di Salvo , Victoria Bunik , Roberto Contestabile , Angela Tramonti

Insights into the substrate specificity, structure, and dynamics of plant histidinol-phosphate aminotransferase (HISN6).

Plant physiology and biochemistry : PPB

Avec: Maria Rutkiewicz , Isabel Nogues , Wojciech Witek , Sebastiana Angelaccio , Roberto Contestabile , Milosz Ruszkowski

Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1.

Molecular cell

Avec: Sharon Spizzichino , Federica Di Fonzo , Chiara Marabelli , Angela Tramonti , Antonio Chaves-Sanjuan , Alessia Parroni , Giovanna Boumis , Francesca Romana Liberati , Alessio Paone , Linda Celeste Montemiglio , Matteo Ardini , Arjen J Jakobi , Alok Bharadwaj , Paolo Swuec , Gian Gaetano Tartaglia , Alessandro Paiardini , Roberto Contestabile , Antonello Mai , Dante Rotili , Francesco Fiorentino , Alberto Macone , Alessandra Giorgi , Giancarlo Tria , Serena Rinaldo , Martino Bolognesi , Giorgio Giardina , Francesca Cutruzzolà

Structural and kinetic properties of serine hydroxymethyltransferase from the halophytic cyanobacterium Aphanothece halophytica provide a rationale for salt tolerance.

International journal of biological macromolecules

Avec: Isabel Nogués , Angela Tramonti , Sebastiana Angelaccio , Milosz Ruszkowski , Bartosz Sekula , Roberto Contestabile

Isolation of a Complex Formed Between

Frontiers in molecular biosciences

Avec: Caterina Nardella , Dalila Boi , Martino L di Salvo , Anna Barile , Jörg Stetefeld , Angela Tramonti , Roberto Contestabile

Allosteric feedback inhibition of pyridoxine 5'-phosphate oxidase from

The Journal of biological chemistry

Avec: Anna Barile , Angela Tramonti , Martino Luigi di Salvo , Isabel Nogués , Caterina Nardella , Francesco Malatesta , Roberto Contestabile

Knowns and Unknowns of Vitamin B

EcoSal Plus

Avec: Angela Tramonti , Caterina Nardella , Martino L di Salvo , Anna Barile , Federico D'Alessio , Valérie de Crécy-Lagard , Roberto Contestabile

Characterization of the Escherichia coli pyridoxal 5'-phosphate homeostasis protein (YggS): Role of lysine residues in PLP binding and protein stability.

Protein science : a publication of the Protein Society

Avec: Angela Tramonti , Mohini S Ghatge , Jill T Babor , Faik N Musayev , Martino Luigi di Salvo , Anna Barile , Gianni Colotti , Alessandra Giorgi , Steven D Paredes , Akua K Donkor , Mohammed H Al Mughram , Valérie de Crécy-Lagard , Martin K Safo , Roberto Contestabile

4'-Deoxypyridoxine disrupts vitamin B

Microbiology (Reading, England)

Avec: Jill Babor , Angela Tramonti , Caterina Nardella , Adam Deutschbauer , Roberto Contestabile , Valérie de Crécy-Lagard

Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models.

Scientific reports

Avec: Milosz Ruszkowski , Bartosz Sekula , Agnieszka Ruszkowska , Roberto Contestabile , Isabel Nogues , Sebastiana Angelaccio , Andrzej Szczepaniak , Zbigniew Dauter

The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity.

Scientific reports

Avec: Elisa Mascolo , Anna Barile , Lorenzo Stufera Mecarelli , Noemi Amoroso , Chiara Merigliano , Arianna Massimi , Isabella Saggio , Torben Hansen , Angela Tramonti , Martino Luigi Di Salvo , Fabrizio Barbetti , Roberto Contestabile , Fiammetta Vernì

Characterization of Novel Pathogenic Variants Causing Pyridox(am)ine 5'-Phosphate Oxidase-Dependent Epilepsy.

International journal of molecular sciences

Avec: Anna Barile , Philippa Mills , Martino L di Salvo , Claudio Graziani , Victoria Bunik , Peter Clayton , Roberto Contestabile , Angela Tramonti

PHA-680626 Is an Effective Inhibitor of the Interaction between Aurora-A and N-Myc.

International journal of molecular sciences

Avec: Dalila Boi , Fani Souvalidou , Davide Capelli , Federica Polverino , Grazia Marini , Roberta Montanari , Giorgio Pochetti , Angela Tramonti , Roberto Contestabile , Daniela Trisciuoglio , Patrizia Carpinelli , Camilla Ascanelli , Catherine Lindon , Alessandro De Leo , Michele Saviano , Roberto Di Santo , Roberta Costi , Giulia Guarguaglini , Alessandro Paiardini

Identification and characterization of the pyridoxal 5'-phosphate allosteric site in Escherichia coli pyridoxine 5'-phosphate oxidase.

The Journal of biological chemistry

Avec: Anna Barile , Theo Battista , Annarita Fiorillo , Martino Luigi di Salvo , Francesco Malatesta , Angela Tramonti , Andrea Ilari , Roberto Contestabile

Vitamin B6 rescues insulin resistance and glucose-induced DNA damage caused by reduced activity of Drosophila PI3K.

Journal of cellular physiology

Avec: Elisa Mascolo , Francesco Liguori , Chiara Merigliano , Ludovica Schiano , Eleonora Gnocchini , Eleonora Pilesi , Cinzia Volonté , Martino L Di Salvo , Roberto Contestabile , Angela Tramonti , Fiammetta Vernì

Isoforms of the DHTKD1-Encoded 2-Oxoadipate Dehydrogenase, Identified in Animal Tissues, Are not Observed upon the Human DHTKD1 Expression in Bacterial or Yeast Systems.

Biochemistry. Biokhimiia

Avec: A I Boyko , A V Artiukhov , T Kaehne , M L di Salvo , M C Bonaccorsi di Patti , R Contestabile , A Tramonti , V I Bunik

Functional Inactivation of

International journal of molecular sciences

Avec: Elisa Mascolo , Francesco Liguori , Lorenzo Stufera Mecarelli , Noemi Amoroso , Chiara Merigliano , Susanna Amadio , Cinzia Volonté , Roberto Contestabile , Angela Tramonti , Fiammetta Vernì

The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism.

Nucleic acids research

Avec: Giulia Guiducci , Alessio Paone , Angela Tramonti , Giorgio Giardina , Serena Rinaldo , Amani Bouzidi , Maria C Magnifico , Marina Marani , Javier A Menendez , Alessandro Fatica , Alberto Macone , Alexandros Armaos , Gian G Tartaglia , Roberto Contestabile , Alessandro Paiardini , Francesca Cutruzzolà

A Novel, Easy Assay Method for Human Cysteine Sulfinic Acid Decarboxylase.

Life (Basel, Switzerland)

Avec: Angela Tramonti , Roberto Contestabile , Rita Florio , Caterina Nardella , Anna Barile , Martino L Di Salvo

Metformin Is a Pyridoxal-5'-phosphate (PLP)-Competitive Inhibitor of SHMT2.

Cancers

Avec: Angela Tramonti , Elisabet Cuyàs , José Antonio Encinar , Matthias Pietzke , Alessio Paone , Sara Verdura , Aina Arbusà , Begoña Martin-Castillo , Giorgio Giardina , Jorge Joven , Alexei Vazquez , Roberto Contestabile , Francesca Cutruzzolà , Javier A Menendez

Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex.

The FEBS journal

Avec: Sharon Spizzichino , Dalila Boi , Giovanna Boumis , Roberta Lucchi , Francesca Romana Liberati , Davide Capelli , Roberta Montanari , Giorgio Pochetti , Roberta Piacentini , Giacomo Parisi , Alessio Paone , Serena Rinaldo , Roberto Contestabile , Angela Tramonti , Alessandro Paiardini , Giorgio Giardina , Francesca Cutruzzolà

Thiamine-dependent regulation of mammalian brain pyridoxal kinase in vitro and in vivo.

Journal of neurochemistry

Avec: Victoria Bunik , Vasily Aleshin , Isabel Nogues , Thilo Kähne , Alessia Parroni , Roberto Contestabile , Martino Luigi Salvo , Anastasia Graf , Angela Tramonti

Arabidopsis thaliana serine hydroxymethyltransferases: functions, structures, and perspectives.

Plant physiology and biochemistry : PPB

Avec: Isabel Nogués , Bartosz Sekula , Sebastiana Angelaccio , Marta Grzechowiak , Angela Tramonti , Roberto Contestabile , Milosz Ruszkowski

Functional and structural properties of pyridoxal reductase (PdxI) from Escherichia coli: a pivotal enzyme in the vitamin B6 salvage pathway.

The FEBS journal

Avec: Angela Tramonti , Akua K Donkor , Alessia Parroni , Faik N Musayev , Anna Barile , Mohini S Ghatge , Claudio Graziani , Mona Alkhairi , Mohammed AlAwadh , Martino Luigi di Salvo , Martin K Safo , Roberto Contestabile

Identification of the pyridoxal 5'-phosphate allosteric site in human pyridox(am)ine 5'-phosphate oxidase.

Protein science : a publication of the Protein Society

Avec: Anna Barile , Claudio Graziani , Lorenzo Antonelli , Alessia Parroni , Annarita Fiorillo , Martino Luigi di Salvo , Andrea Ilari , Alessandra Giorgi , Serena Rosignoli , Alessandro Paiardini , Roberto Contestabile , Angela Tramonti

The Z isomer of pyridoxilidenerhodanine 5'-phosphate is an efficient inhibitor of human pyridoxine 5'-phosphate oxidase, a crucial enzyme in vitamin B

The FEBS journal

Avec: Claudio Graziani , Anna Barile , Lorenzo Antonelli , Annarita Fiorillo , Andrea Ilari , Fabrizio Vetica , Martino Luigi di Salvo , Alessandro Paiardini , Angela Tramonti , Roberto Contestabile

The multifaceted role of vitamin B

Open biology

Avec: Roberto Contestabile , Martino Luigi di Salvo , Victoria Bunik , Angela Tramonti , Fiammetta Vernì

An Engineered Escherichia coli Strain with Synthetic Metabolism for in-Cell Production of Translationally Active Methionine Derivatives.

Chembiochem : a European journal of chemical biology

Avec: Christian Johannes Schipp , Ying Ma , Ammar Al-Shameri , Federico D'Alessio , Peter Neubauer , Roberto Contestabile , Nediljko Budisa , Martino Luigi di Salvo

Interaction of Bacillus subtilis GabR with the gabTD promoter: role of repeated sequences and effect of GABA in transcriptional activation.

The FEBS journal

Avec: Caterina Nardella , Anna Barile , Martino L di Salvo , Teresa Milano , Stefano Pascarella , Angela Tramonti , Roberto Contestabile

A gene-nutrient interaction between vitamin B6 and serine hydroxymethyltransferase (SHMT) affects genome integrity in Drosophila.

Journal of cellular physiology

Avec: Eleonora Pilesi , Chiara Angioli , Claudio Graziani , Alessia Parroni , Roberto Contestabile , Angela Tramonti , Fiammetta Vernì

Structural insights into the DNA recognition mechanism by the bacterial transcription factor PdxR.

Nucleic acids research

Avec: Ida Freda , Cécile Exertier , Anna Barile , Antonio Chaves-Sanjuan , Mirella Vivoli Vega , Michail N Isupov , Nicholas J Harmer , Elena Gugole , Paolo Swuec , Martino Bolognesi , Anita Scipioni , Carmelinda Savino , Martino Luigi Di Salvo , Roberto Contestabile , Beatrice Vallone , Angela Tramonti , Linda Celeste Montemiglio

One substrate many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse.

Nature communications

Avec: Marco Malatesta , Emanuele Fornasier , Martino Luigi Di Salvo , Angela Tramonti , Erika Zangelmi , Alessio Peracchi , Andrea Secchi , Eugenia Polverini , Gabriele Giachin , Roberto Battistutta , Roberto Contestabile , Riccardo Percudani

Vitamin B6 deficiency cooperates with oncogenic Ras to induce malignant tumors in Drosophila.

Cell death & disease

Avec: Eleonora Pilesi , Giulia Tesoriere , Angelo Ferriero , Elisa Mascolo , Francesco Liguori , Luca Argirò , Chiara Angioli , Angela Tramonti , Roberto Contestabile , Cinzia Volontè , Fiammetta Vernì

Réseau de co-auteurs

Angela Tramonti 29 collaborations

Anna Barile 14 collaborations

Martino Luigi di Salvo 8 collaborations

Alessandro Paiardini 6 collaborations

Caterina Nardella 6 collaborations

Fiammetta Vernì 6 collaborations

Martino L di Salvo 5 collaborations

Alessia Parroni 5 collaborations

Claudio Graziani 5 collaborations

Isabel Nogués 4 collaborations

Victoria Bunik 4 collaborations

Sebastiana Angelaccio 4 collaborations

Milosz Ruszkowski 4 collaborations

Alessio Paone 4 collaborations

Giorgio Giardina 4 collaborations

Francesca Cutruzzolà 4 collaborations

Elisa Mascolo 4 collaborations

Isabel Nogues 3 collaborations

Alessandra Giorgi 3 collaborations

Serena Rinaldo 3 collaborations

Bartosz Sekula 3 collaborations

Dalila Boi 3 collaborations

Valérie de Crécy-Lagard 3 collaborations

Chiara Merigliano 3 collaborations

Martino Luigi Di Salvo 3 collaborations

Annarita Fiorillo 3 collaborations

Andrea Ilari 3 collaborations

Francesco Liguori 3 collaborations

Eleonora Pilesi 3 collaborations

Sharon Spizzichino 2 collaborations

Antonio Chaves-Sanjuan 2 collaborations

Giovanna Boumis 2 collaborations

Francesca Romana Liberati 2 collaborations

Linda Celeste Montemiglio 2 collaborations

Paolo Swuec 2 collaborations

Alberto Macone 2 collaborations

Martino Bolognesi 2 collaborations

Francesco Malatesta 2 collaborations

Federico D'Alessio 2 collaborations

Mohini S Ghatge 2 collaborations

Faik N Musayev 2 collaborations

Akua K Donkor 2 collaborations

Martin K Safo 2 collaborations

Lorenzo Stufera Mecarelli 2 collaborations

Noemi Amoroso 2 collaborations

Davide Capelli 2 collaborations

Roberta Montanari 2 collaborations

Giorgio Pochetti 2 collaborations

Cinzia Volonté 2 collaborations

Martino L Di Salvo 2 collaborations

Javier A Menendez 2 collaborations

Lorenzo Antonelli 2 collaborations

Chiara Angioli 2 collaborations

Maria Rutkiewicz 1 collaboration

Wojciech Witek 1 collaboration

Federica Di Fonzo 1 collaboration

Chiara Marabelli 1 collaboration

Matteo Ardini 1 collaboration

Arjen J Jakobi 1 collaboration

Alok Bharadwaj 1 collaboration

Gian Gaetano Tartaglia 1 collaboration

Antonello Mai 1 collaboration

Dante Rotili 1 collaboration

Francesco Fiorentino 1 collaboration

Giancarlo Tria 1 collaboration

Jörg Stetefeld 1 collaboration

Jill T Babor 1 collaboration

Gianni Colotti 1 collaboration

Steven D Paredes 1 collaboration

Mohammed H Al Mughram 1 collaboration

Jill Babor 1 collaboration

Adam Deutschbauer 1 collaboration

Agnieszka Ruszkowska 1 collaboration

Andrzej Szczepaniak 1 collaboration

Zbigniew Dauter 1 collaboration

Arianna Massimi 1 collaboration

Isabella Saggio 1 collaboration

Torben Hansen 1 collaboration

Fabrizio Barbetti 1 collaboration

Philippa Mills 1 collaboration

Peter Clayton 1 collaboration

Fani Souvalidou 1 collaboration

Federica Polverino 1 collaboration

Grazia Marini 1 collaboration

Daniela Trisciuoglio 1 collaboration

Patrizia Carpinelli 1 collaboration

Camilla Ascanelli 1 collaboration

Catherine Lindon 1 collaboration

Alessandro De Leo 1 collaboration

Michele Saviano 1 collaboration

Roberto Di Santo 1 collaboration

Roberta Costi 1 collaboration

Giulia Guarguaglini 1 collaboration

Theo Battista 1 collaboration

Ludovica Schiano 1 collaboration

Eleonora Gnocchini 1 collaboration

A I Boyko 1 collaboration

A V Artiukhov 1 collaboration

T Kaehne 1 collaboration

M L di Salvo 1 collaboration

M C Bonaccorsi di Patti 1 collaboration

R Contestabile 1 collaboration

A Tramonti 1 collaboration

V I Bunik 1 collaboration

Susanna Amadio 1 collaboration

Giulia Guiducci 1 collaboration

Amani Bouzidi 1 collaboration

Maria C Magnifico 1 collaboration

Marina Marani 1 collaboration

Alessandro Fatica 1 collaboration

Alexandros Armaos 1 collaboration

Gian G Tartaglia 1 collaboration

Rita Florio 1 collaboration

Elisabet Cuyàs 1 collaboration

José Antonio Encinar 1 collaboration

Matthias Pietzke 1 collaboration

Sara Verdura 1 collaboration

Aina Arbusà 1 collaboration

Begoña Martin-Castillo 1 collaboration

Jorge Joven 1 collaboration

Alexei Vazquez 1 collaboration

Roberta Lucchi 1 collaboration

Roberta Piacentini 1 collaboration

Giacomo Parisi 1 collaboration

Vasily Aleshin 1 collaboration

Thilo Kähne 1 collaboration

Martino Luigi Salvo 1 collaboration

Anastasia Graf 1 collaboration

Marta Grzechowiak 1 collaboration

Mona Alkhairi 1 collaboration

Mohammed AlAwadh 1 collaboration

Serena Rosignoli 1 collaboration

Fabrizio Vetica 1 collaboration

Christian Johannes Schipp 1 collaboration

Ying Ma 1 collaboration

Ammar Al-Shameri 1 collaboration

Peter Neubauer 1 collaboration

Nediljko Budisa 1 collaboration

Teresa Milano 1 collaboration

Stefano Pascarella 1 collaboration

Ida Freda 1 collaboration

Cécile Exertier 1 collaboration

Mirella Vivoli Vega 1 collaboration

Michail N Isupov 1 collaboration

Nicholas J Harmer 1 collaboration

Elena Gugole 1 collaboration

Anita Scipioni 1 collaboration

Carmelinda Savino 1 collaboration

Beatrice Vallone 1 collaboration

Marco Malatesta 1 collaboration

Emanuele Fornasier 1 collaboration

Erika Zangelmi 1 collaboration

Alessio Peracchi 1 collaboration

Andrea Secchi 1 collaboration

Eugenia Polverini 1 collaboration

Gabriele Giachin 1 collaboration

Roberto Battistutta 1 collaboration

Riccardo Percudani 1 collaboration

Giulia Tesoriere 1 collaboration

Angelo Ferriero 1 collaboration

Luca Argirò 1 collaboration

Cinzia Volontè 1 collaboration