Characterization of the Escherichia coli pyridoxal 5'-phosphate homeostasis protein (YggS): Role of lysine residues in PLP binding and protein stability.

Escherichia coli / metabolism Lysine / metabolism Pyridoxal Phosphate Proteins / chemistry Protein Stability Homeostasis Phosphates / metabolism Carrier Proteins / genetics Escherichia coli Proteins / genetics
COG0325 family PLPHP YggS pyridoxal 5′-phosphate vitamin B6

Journal

Protein science : a publication of the Protein Society
ISSN: 1469-896X
Titre abrégé: Protein Sci
Pays: United States
ID NLM: 9211750

Informations de publication

Date de publication:
Nov 2022
Historique:
revised: 04 07 2022
received: 12 05 2022
accepted: 25 07 2022
pubmed: 12 10 2022
medline: 2 11 2022
entrez: 11 10 2022
Statut: ppublish

Résumé

The pyridoxal 5'-phosphate (PLP) homeostasis protein (PLPHP) is a ubiquitous member of the COG0325 family with apparently no catalytic activity. Although the actual cellular role of this protein is unknown, it has been observed that mutations of the PLPHP encoding gene affect the activity of PLP-dependent enzymes, B

Identifiants

DOI: 10.1002/pro.4471 PMID: 36218140 PMC: PMC9601805
pubmed: 36218140
doi: 10.1002/pro.4471
pmc: PMC9601805
doi:

Substances chimiques

Lysine K3Z4F929H6
Pyridoxal Phosphate 5V5IOJ8338
Proteins 0
Phosphates 0
YggS protein, E coli 0
Carrier Proteins 0
Escherichia coli Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e4471

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM129793
Pays : United States
Organisme : NIH HHS
ID : S10 OD021756
Pays : United States

Informations de copyright

© 2022 The Authors. Protein Science published by Wiley Periodicals LLC on behalf of The Protein Society.

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Auteurs

Angela Tramonti (A)

Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Rome, Italy.
Istituto Pasteur Italia-Fondazione Cenci Bolognetti and Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, Rome, Italy.

Mohini S Ghatge (MS)

Institute for Structural Biology, Drug Discovery and Development, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia, USA.

Jill T Babor (JT)

Department of Microbiology and Cell Science, University of Florida, Gainsville, Florida, USA.

Faik N Musayev (FN)

Institute for Structural Biology, Drug Discovery and Development, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia, USA.

Martino Luigi di Salvo (ML)

Istituto Pasteur Italia-Fondazione Cenci Bolognetti and Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, Rome, Italy.

Anna Barile (A)

Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Rome, Italy.
Istituto Pasteur Italia-Fondazione Cenci Bolognetti and Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, Rome, Italy.

Gianni Colotti (G)

Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Rome, Italy.

Alessandra Giorgi (A)

Istituto Pasteur Italia-Fondazione Cenci Bolognetti and Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, Rome, Italy.

Steven D Paredes (SD)

Institute for Structural Biology, Drug Discovery and Development, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia, USA.

Akua K Donkor (AK)

Institute for Structural Biology, Drug Discovery and Development, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia, USA.

Mohammed H Al Mughram (MH)

Institute for Structural Biology, Drug Discovery and Development, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia, USA.

Valérie de Crécy-Lagard (V)

Department of Microbiology and Cell Science, University of Florida, Gainsville, Florida, USA.
Genetics Institute, University of Florida, Gainesville, Florida, USA.

Martin K Safo (MK)

Institute for Structural Biology, Drug Discovery and Development, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia, USA.

Roberto Contestabile (R)

Istituto Pasteur Italia-Fondazione Cenci Bolognetti and Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, Rome, Italy.
ORCID: 0000-0002-5235-9993

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Classifications MeSH

questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Characterization of the Escherichia coli...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Lysine › Characterization of the Escherichia coli...
questionsmedicales.fr › Enzymes et coenzymes › Coenzymes › Phosphate de pyridoxal › Characterization of the Escherichia coli...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Characterization of the Escherichia coli...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Stabilité protéique › Characterization of the Escherichia coli...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Characterization of the Escherichia coli...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du phosphore › Acides du phosphore › Acides phosphoriques › Phosphates › Characterization of the Escherichia coli...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Characterization of the Escherichia coli...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Protéines Escherichia coli › Characterization of the Escherichia coli...