Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases.
Antiprotozoal Agents
/ chemistry
Binding Sites
Drug Design
Drug Development
/ methods
Leishmania
/ drug effects
Models, Molecular
Molecular Conformation
NADH, NADPH Oxidoreductases
/ antagonists & inhibitors
Oxidation-Reduction
/ drug effects
Protein Binding
Protein Multimerization
Structure-Activity Relationship
Substrate Specificity
Trypanosoma
/ drug effects
protein crystallography
rational drug discovery
structure-based drug design
trypanosomatid infection
trypanothione reductase
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
21 Apr 2020
21 Apr 2020
Historique:
received:
04
04
2020
revised:
16
04
2020
accepted:
20
04
2020
entrez:
25
4
2020
pubmed:
25
4
2020
medline:
22
1
2021
Statut:
epublish
Résumé
The protozoans
Identifiants
pubmed: 32326257
pii: molecules25081924
doi: 10.3390/molecules25081924
pmc: PMC7221613
pii:
doi:
Substances chimiques
Antiprotozoal Agents
0
NADH, NADPH Oxidoreductases
EC 1.6.-
trypanothione reductase
EC 1.8.1.12
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
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