Chikungunya and Mayaro infective viruses in components of blood.
Alphavirus Chikungunya
Alphavirus Mayaro
arbovirus
blood
components
viremia
Journal
Transfusion medicine (Oxford, England)
ISSN: 1365-3148
Titre abrégé: Transfus Med
Pays: England
ID NLM: 9301182
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
revised:
05
12
2021
received:
15
01
2021
accepted:
01
02
2022
pubmed:
11
3
2022
medline:
11
6
2022
entrez:
10
3
2022
Statut:
ppublish
Résumé
Evaluate the infectivity of Alphavirus Chikungunya and Mayaro in blood products in plaque forming units (UFP/ml). Arboviruses are responsible for sporadic diseases or epidemics which cause serious public health issues. Due to the high number of asymptomatic infections and high viremia, blood donors may pass on these viruses by transfusion. This study used blood bags that would be discarded after evaluation and certification of the absence of infections. The blood products obtained by centrifuging a unit of whole blood were called blood components. All blood bags were infected with viable viruses (previously quantified) compatible with Chikungunya and Mayaro viremia. Blood bags inoculated with both Chikungunya and Mayaro viruses were able to keep infective viruses during the processing of blood products (red blood cell concentrate, platelet concentrate and fresh frozen plasma) and also after the recommended storage for each component, which may infect individuals transfused with those. The results indicate that in order to prevent infections by Mayaro and Chikungunya viruses in blood products it is necessary to stimulate the development and use of diagnostic tests for these pathogens in donated blood.
Sections du résumé
OBJECTIVE
OBJECTIVE
Evaluate the infectivity of Alphavirus Chikungunya and Mayaro in blood products in plaque forming units (UFP/ml).
BACKGROUND
BACKGROUND
Arboviruses are responsible for sporadic diseases or epidemics which cause serious public health issues. Due to the high number of asymptomatic infections and high viremia, blood donors may pass on these viruses by transfusion.
METHODS/MATERIALS
METHODS
This study used blood bags that would be discarded after evaluation and certification of the absence of infections. The blood products obtained by centrifuging a unit of whole blood were called blood components. All blood bags were infected with viable viruses (previously quantified) compatible with Chikungunya and Mayaro viremia.
RESULTS
RESULTS
Blood bags inoculated with both Chikungunya and Mayaro viruses were able to keep infective viruses during the processing of blood products (red blood cell concentrate, platelet concentrate and fresh frozen plasma) and also after the recommended storage for each component, which may infect individuals transfused with those.
CONCLUSION
CONCLUSIONS
The results indicate that in order to prevent infections by Mayaro and Chikungunya viruses in blood products it is necessary to stimulate the development and use of diagnostic tests for these pathogens in donated blood.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
252-255Subventions
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 134303/2018-0
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2014/01146-1
Informations de copyright
© 2022 British Blood Transfusion Society.
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