Methyl Donors Reduce Cell Proliferation by Diminishing Erk-Signaling and NFkB Levels, While Increasing E-Cadherin Expression in Panc-1 Cell Line.
E-cadherin
apoptosis
cell cycle
methyl donors
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 Feb 2022
25 Feb 2022
Historique:
received:
08
01
2022
revised:
22
02
2022
accepted:
24
02
2022
entrez:
10
3
2022
pubmed:
11
3
2022
medline:
9
4
2022
Statut:
epublish
Résumé
Pancreatic cancer is an aggressive malignancy with high metastatic potential. There are several lifestyle-related determinants in its etiology, including diet. Methyl donors are dietary micronutrients which play an important role in fueling vital metabolic pathways, and as bioactive food components provide methyl groups as substrates and cofactors. The imbalanced nutritional status of methyl donors has recently been linked to pathological conditions. Therefore, we hypothesized that dietary methyl donors may improve the physiology of cancer patients, including those with pancreatic cancer, and could be used for intervention therapy. In this study, methyl-donor treatment (L-methionine, choline chloride, folic acid and vitamin B12) of an aggressive pancreatic adenocarcinoma cell line (Panc-1) resulted in significantly increased p21
Identifiants
pubmed: 35269689
pii: ijms23052546
doi: 10.3390/ijms23052546
pmc: PMC8910410
pii:
doi:
Substances chimiques
Cadherins
0
Cyclin-Dependent Kinase Inhibitor p21
0
NF-kappa B
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Ministry of Hungary for Innovation and Technology
ID : NVKP_16-1-2016-0042
Organisme : National Research, Development and Innovation Office of Hungary
ID : ÚNKP-21-4-I-SE-19
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