Synthesis, Biological Activity and Molecular Docking Studies of Novel Nicotinic Acid Derivatives.
N-acetyl-1,3,4-oxadiazoline derivatives
acylhydrazones
antimicrobial activity
cytotoxicity
molecular modelling
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 Mar 2022
04 Mar 2022
Historique:
received:
04
02
2022
revised:
23
02
2022
accepted:
24
02
2022
entrez:
10
3
2022
pubmed:
11
3
2022
medline:
9
4
2022
Statut:
epublish
Résumé
In our research, we used nicotinic acid as a starting compound, which was subjected to a series of condensation reactions with appropriate aldehydes. As a result of these reactions, we were able to obtain a series of twelve acylhydrazones, two of which showed promising activity against Gram-positive bacteria (MIC = 1.95-15.62 µg/mL), especially against
Identifiants
pubmed: 35269966
pii: ijms23052823
doi: 10.3390/ijms23052823
pmc: PMC8911400
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Niacin
2679MF687A
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
J Antimicrob Chemother. 2013 Jan;68(1):51-9
pubmed: 22977158
Chem Rev. 2021 Mar 24;121(6):3390-3411
pubmed: 32441527
J Infect Dis. 2017 Aug 15;216(suppl_3):S445-S451
pubmed: 28911043
J Clin Invest. 2012 Sep;122(9):3316-29
pubmed: 22922257
Eur J Med Chem. 2008 Sep;43(9):1989-96
pubmed: 18207286
Bioorg Med Chem Lett. 2006 Oct 1;16(19):5036-40
pubmed: 16876405
P T. 2015 Apr;40(4):277-83
pubmed: 25859123
Biomed Pharmacother. 2018 Jul;103:1337-1347
pubmed: 29864916
Pharmaceuticals (Basel). 2018 May 29;11(2):
pubmed: 29844300
Clin Microbiol Rev. 2020 Nov 11;34(1):
pubmed: 33177185
J Med Chem. 2004 Jul 15;47(15):3755-64
pubmed: 15239654
Bioorg Med Chem. 2014 Sep 1;22(17):4629-36
pubmed: 25127462
Pest Manag Sci. 2013 Jun;69(6):703-8
pubmed: 23117879
J Orthop Surg Res. 2021 Feb 1;16(1):100
pubmed: 33522930
Cell. 2017 Nov 30;171(6):1354-1367.e20
pubmed: 29103614
Infect Drug Resist. 2018 Nov 20;11:2363-2375
pubmed: 30538504
Front Public Health. 2021 May 31;9:658638
pubmed: 34136453
Bioorg Med Chem. 2006 Dec 15;14(24):8675-82
pubmed: 16949294
Lancet Infect Dis. 2013 Dec;13(12):1057-98
pubmed: 24252483
Antibiotics (Basel). 2021 Feb 18;10(2):
pubmed: 33670659
Molecules. 2020 Mar 16;25(6):
pubmed: 32187986
IDCases. 2021 Jul 06;25:e01216
pubmed: 34285874
Eur J Pediatr. 2022 Mar;181(3):1099-1104
pubmed: 34738172
Bioorg Chem. 2019 Aug;89:103013
pubmed: 31174040
Adv Drug Deliv Rev. 2022 Feb;181:114078
pubmed: 34896131
Eur J Med Chem. 2015;96:504-18
pubmed: 25951294
J Med Chem. 2016 Jul 14;59(13):6493-500
pubmed: 27308944
Clin Microbiol Infect. 2000 Sep;6(9):509-15
pubmed: 11168187
Farmaco. 2002 Feb;57(2):171-4
pubmed: 11902660
Am J Infect Control. 2020 Sep;48(9):1090-1099
pubmed: 32311380
Antimicrob Agents Chemother. 2013 Apr;57(4):1638-47
pubmed: 23335745
J Glob Antimicrob Resist. 2022 Feb 5;29:23-28
pubmed: 35134551
J Comput Chem. 2010 Jan 30;31(2):455-61
pubmed: 19499576
Biotechnol Rep (Amst). 2021 Feb 23;29:e00604
pubmed: 33732632
Clin Microbiol Rev. 2020 Dec 23;34(2):
pubmed: 33361142
Chem Biodivers. 2019 Jun;16(6):e1900082
pubmed: 31050208
Eur J Med Chem. 2006 May;41(5):624-32
pubmed: 16540208
AIMS Microbiol. 2018 Jun 26;4(3):482-501
pubmed: 31294229
Tuberc Res Treat. 2011;2011:986409
pubmed: 22567272
Chemother Res Pract. 2014;2014:972646
pubmed: 25180095
J Glob Antimicrob Resist. 2020 Dec;23:430-438
pubmed: 33176216
Eur J Med Chem. 2003 Nov-Dec;38(11-12):1005-13
pubmed: 14642333
Chem Biol Drug Des. 2018 Apr;91(4):915-923
pubmed: 29220872
J Infect. 2020 Aug;81(2):318-356
pubmed: 32417312
Clin Microbiol Rev. 2014 Oct;27(4):870-926
pubmed: 25278577
Molecules. 2010 Dec 23;16(1):16-27
pubmed: 21187814
J Biol Chem. 2005 Apr 8;280(14):13256-64
pubmed: 15684426
J Microbiol Biotechnol. 2019 Sep 28;29(9):1460-1469
pubmed: 31434169
J Biol Chem. 2020 May 22;295(21):7529-7543
pubmed: 32253235
Bioorg Med Chem. 2002 Jul;10(7):2193-8
pubmed: 11983516
Curr Pharm Des. 2020;26(8):867-904
pubmed: 32026773
J Pak Med Assoc. 2021 May;71(5):1472-1475
pubmed: 34091637
Antimicrob Agents Chemother. 2017 Jul 25;61(8):
pubmed: 28559260
Antimicrob Agents Chemother. 1986 Dec;30(6):856-60
pubmed: 3101587