Gastrointestinal Symptoms and Dopamine Transporter Asymmetry in Early Parkinson's Disease.
Parkinson's diseasegastrointestinal symptomsdopamine transporter
Journal
Movement disorders : official journal of the Movement Disorder Society
ISSN: 1531-8257
Titre abrégé: Mov Disord
Pays: United States
ID NLM: 8610688
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
revised:
01
02
2022
received:
04
12
2021
accepted:
13
02
2022
pubmed:
12
3
2022
medline:
18
6
2022
entrez:
11
3
2022
Statut:
ppublish
Résumé
The neurophysiological correlates of gastrointestinal symptoms (GISs) in Parkinson's disease (PD) are not well understood. It has been proposed that in patients with a gastrointestinal origin of PD dopaminergic neurodegeneration would be more symmetric. The aim is to assess the associations between GISs and asymmetry of nigrostriatal dopaminergic neurodegeneration in PD. Ninety PD patients were assessed using motor and GIS scales and There were no significant differences in GISs between symmetric and asymmetric dopaminergic defect. Left predominant defect was related to more GIS and higher constipation scores. GISs were associated with left predominant reduction in putaminal DAT binding but not asymmetry per se. It remains open whether left-sided DAT deficit is related to more pronounced GI involvement or symptom perception in PD. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson Movement Disorder Society.
Sections du résumé
BACKGROUND
The neurophysiological correlates of gastrointestinal symptoms (GISs) in Parkinson's disease (PD) are not well understood. It has been proposed that in patients with a gastrointestinal origin of PD dopaminergic neurodegeneration would be more symmetric.
OBJECTIVES
The aim is to assess the associations between GISs and asymmetry of nigrostriatal dopaminergic neurodegeneration in PD.
METHODS
Ninety PD patients were assessed using motor and GIS scales and
RESULTS
There were no significant differences in GISs between symmetric and asymmetric dopaminergic defect. Left predominant defect was related to more GIS and higher constipation scores.
CONCLUSIONS
GISs were associated with left predominant reduction in putaminal DAT binding but not asymmetry per se. It remains open whether left-sided DAT deficit is related to more pronounced GI involvement or symptom perception in PD. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson Movement Disorder Society.
Identifiants
pubmed: 35274368
doi: 10.1002/mds.28986
pmc: PMC9314058
doi:
Substances chimiques
Dopamine Plasma Membrane Transport Proteins
0
Tropanes
0
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1284-1289Informations de copyright
© 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson Movement Disorder Society.
Références
J Parkinsons Dis. 2021;11(2):455-474
pubmed: 33682732
Dis Colon Rectum. 1996 Jun;39(6):681-5
pubmed: 8646957
Neurology. 2001 Aug 14;57(3):456-62
pubmed: 11502913
Eur J Neurol. 2013 Jan;20(1):16-34
pubmed: 23279440
J Neurogastroenterol Motil. 2018 Jul 30;24(3):469-478
pubmed: 29969861
J Gastrointestin Liver Dis. 2006 Sep;15(3):237-41
pubmed: 17013448
Neuron. 2018 Sep 19;99(6):1116-1128
pubmed: 30236282
Parkinsonism Relat Disord. 2018 Oct;55:8-14
pubmed: 30146185
Ann Clin Transl Neurol. 2015 Dec 05;3(1):21-6
pubmed: 26783547
Cell Tissue Res. 2018 Jul;373(1):297-312
pubmed: 29656343
Brain. 2020 Oct 1;143(10):3077-3088
pubmed: 32830221
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
J Parkinsons Dis. 2017;7(2):353-357
pubmed: 28157108
Mov Disord. 2010 Jan 15;25(1):70-5
pubmed: 20014110
Mov Disord. 2003 Oct;18 Suppl 7:S43-51
pubmed: 14531046
J Parkinsons Dis. 2017;7(2):359-367
pubmed: 28157109
Mov Disord. 2012 Jun;27(7):913-6
pubmed: 22729987
J Int Neuropsychol Soc. 2015 Apr;21(4):259-70
pubmed: 25923830
Eur J Neurol. 2017 Nov;24(11):1375-1383
pubmed: 28891262
Mov Disord. 2008 Nov 15;23(15):2129-70
pubmed: 19025984
Eur J Nucl Med Mol Imaging. 2014 Oct;41(10):1931-7
pubmed: 24867256
Parkinsons Dis. 2016;2016:6762528
pubmed: 28050310
Parkinsonism Relat Disord. 2022 Feb;95:107-112
pubmed: 35093712
Auton Neurosci. 2019 Jan;216:59-62
pubmed: 30236547
World J Gastroenterol. 2021 Mar 21;27(11):1055-1063
pubmed: 33776372
Mov Disord. 2007 Oct 15;22(13):1901-11
pubmed: 17674410
Acta Neuropathol. 2019 Nov;138(5):771-782
pubmed: 31494694
Mov Disord. 2021 Oct;36(10):2303-2313
pubmed: 34124799
Parkinsonism Relat Disord. 2009 May;15(4):315-7
pubmed: 18793864
Dis Colon Rectum. 2008 Feb;51(2):162-72
pubmed: 18172725
Acta Neuropathol. 2010 Jun;119(6):689-702
pubmed: 20306269
Neurobiol Dis. 2022 Feb;163:105599
pubmed: 34952161
J Neurol. 2020 Jul;267(7):1922-1930
pubmed: 32162062
J Parkinsons Dis. 2021;11(4):1677-1687
pubmed: 34334424