Tuning the Elasticity of Nanogels Improves Their Circulation Time by Evading Immune Cells.

Blood Circulation Time Elasticity Microgels Nanogels Positron Emission Tomography Computed Tomography
Biodistribution Elasticity Nanogels Phagocytosis Radiolabeling

Journal

Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543

Informations de publication

Date de publication:
09 05 2022
Historique:
received: 06 12 2021
pubmed: 12 3 2022
medline: 4 5 2022
entrez: 11 3 2022
Statut: ppublish

Résumé

Peptide receptor radionuclide therapy is used to treat solid tumors by locally delivering radiation. However, due to nephro- and hepato-toxicity, it is limited by its dosage. To amplify radiation damage to tumor cells, radiolabeled nanogels can be used. We show that by tuning the mechanical properties of nanogels significant enhancement in circulation half-life of the gel could be achieved. We demonstrate why and how small changes in the mechanical properties of the nanogels influence its cellular fate. Nanogels with a storage modulus of 37 kPa were minimally phagocytosed by monocytes and macrophages compared to nanogels with 93 kPa modulus. Using PET/CT a significant difference in the blood circulation time of the nanogels was shown. Computer simulations affirmed the results and predicted the mechanism of cellular uptake of the nanogels. Altogether, this work emphasizes the important role of elasticity even for particles that are inherently soft such as nano- or microgels.

Identifiants

DOI: 10.1002/anie.202116653 PMID: 35274425 PMC: PMC9325431
pubmed: 35274425
doi: 10.1002/anie.202116653
pmc: PMC9325431
doi:

Substances chimiques

Microgels 0
Nanogels 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e202116653

Informations de copyright

© 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.

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Auteurs

Prachi Desai (P)

DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany.
ORCID: 0000-0003-2471-0739

Rahul Rimal (R)

DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany.
ORCID: 0000-0003-0923-480X

Alexandru Florea (A)

Department of Nuclear Medicine, University Hospital RWTH Aachen, Pauwelstraße 30, 52074, Aachen, Germany.
Department of Radiology and Nuclear Medicine, School for Cardiovascular Diseases (CARIM) and School for Oncology (GROW), Maastricht University, 6229 HX, Maastricht, The Netherlands.

Rustam A Gumerov (RA)

DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany.
Physics Department, Lomonosov Moscow State University, Leninskie Gory 1-2, 119991, Moscow, Russian Federation.
ORCID: 0000-0003-4214-8129

Marta Santi (M)

DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany.

Anastasia S Sorokina (AS)

Physics Department, Lomonosov Moscow State University, Leninskie Gory 1-2, 119991, Moscow, Russian Federation.

Sabri E M Sahnoun (SEM)

Department of Nuclear Medicine, University Hospital RWTH Aachen, Pauwelstraße 30, 52074, Aachen, Germany.

Thorsten Fischer (T)

DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany.

Felix M Mottaghy (FM)

Department of Nuclear Medicine, University Hospital RWTH Aachen, Pauwelstraße 30, 52074, Aachen, Germany.
Department of Radiology and Nuclear Medicine, School for Cardiovascular Diseases (CARIM) and School for Oncology (GROW), Maastricht University, 6229 HX, Maastricht, The Netherlands.

Agnieszka Morgenroth (A)

Department of Nuclear Medicine, University Hospital RWTH Aachen, Pauwelstraße 30, 52074, Aachen, Germany.

Ahmed Mourran (A)

DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany.

Igor I Potemkin (II)

DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany.
Physics Department, Lomonosov Moscow State University, Leninskie Gory 1-2, 119991, Moscow, Russian Federation.
National Research South Ural State University, Chelyabinsk, 454080, Russian Federation.
ORCID: 0000-0002-3023-580X

Martin Möller (M)

DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany.

Smriti Singh (S)

DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany.
Max Planck Institute for Medical Research (MPImF), Jahnstrasse 29, 69120, Heidelberg, Germany.
ORCID: 0000-0002-2164-9912

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Classifications MeSH

questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic cardiovasculaire › Temps de circulation sanguine › Tuning the Elasticity of Nanogels Improves...
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Élasticité › Tuning the Elasticity of Nanogels Improves...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Microgels › Tuning the Elasticity of Nanogels Improves...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Nanogels › Tuning the Elasticity of Nanogels Improves...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Tomographie par émission de positons couplée à la tomodensitométrie › Tuning the Elasticity of Nanogels Improves...