Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5.
axon degeneration
axon/glia-interaction
differential myelin proteome analysis
focused ion beam scanning electron microscopy
mouse
myelin sheath
neuroscience
oligodendrocyte
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
11 03 2022
11 03 2022
Historique:
received:
12
11
2021
accepted:
27
02
2022
entrez:
11
3
2022
pubmed:
12
3
2022
medline:
30
4
2022
Statut:
epublish
Résumé
Oligodendrocytes facilitate rapid impulse propagation along the axons they myelinate and support their long-term integrity. However, the functional relevance of many myelin proteins has remained unknown. Here, we find that expression of the tetraspan-transmembrane protein CMTM5 (chemokine-like factor-like MARVEL-transmembrane domain containing protein 5) is highly enriched in oligodendrocytes and central nervous system (CNS) myelin. Genetic disruption of the
Identifiants
pubmed: 35274615
doi: 10.7554/eLife.75523
pii: 75523
pmc: PMC8916772
doi:
pii:
Substances chimiques
Myelin Proteins
0
Banques de données
GEO
['GSE118257', 'GSE140511']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
© 2022, Buscham et al.
Déclaration de conflit d'intérêts
TB, ME, AS, OJ, NS, RD, TM, SS, CM, TS, TR, WM, EK, SB, HW No competing interests declared, MM MM is affiliated with Abberior Instruments Gmbh; the author has no financial interests to declare, KN Reviewing editor, eLife
Références
Science. 2012 Jul 27;337(6093):481-4
pubmed: 22678360
Front Cell Neurosci. 2020 Aug 19;14:239
pubmed: 32973451
Nature. 2012 Apr 29;485(7399):517-21
pubmed: 22622581
PLoS Biol. 2020 Dec 22;18(12):e3000621
pubmed: 33351792
Cell. 2020 Jan 23;180(2):311-322.e15
pubmed: 31883793
Brain. 2021 Nov 29;144(10):3226-3238
pubmed: 33964142
PLoS Biol. 2020 Nov 16;18(11):e3000943
pubmed: 33196637
Front Mol Biosci. 2021 Jul 08;8:703532
pubmed: 34307460
Elife. 2021 Apr 23;10:
pubmed: 33890853
Eur J Neurosci. 1989;1(1):27-33
pubmed: 12106171
EMBO Mol Med. 2012 Jun;4(6):528-39
pubmed: 22473874
J Neurosci. 2014 Sep 3;34(36):11929-47
pubmed: 25186741
Genomics. 2003 Jun;81(6):609-17
pubmed: 12782130
Elife. 2019 Jan 23;8:
pubmed: 30672734
Nat Med. 2020 Jan;26(1):131-142
pubmed: 31932797
Magn Reson Med. 2015 Feb;73(2):843-50
pubmed: 24664497
Clin Cancer Res. 2007 Oct 1;13(19):5756-62
pubmed: 17908965
Nat Rev Neurosci. 2020 Apr;21(4):183-196
pubmed: 32152523
Glia. 2005 Apr 1;50(1):86-90
pubmed: 15657937
Glia. 2017 Nov;65(11):1762-1776
pubmed: 28836307
Neuron. 2016 Jul 6;91(1):119-32
pubmed: 27292539
Cell Rep. 2021 Jan 5;34(1):108588
pubmed: 33406435
Nat Genet. 2003 Mar;33(3):366-74
pubmed: 12590258
Cell Metab. 2020 Aug 4;32(2):259-272.e10
pubmed: 32531201
Biophys J. 1994 Jan;66(1):259-67
pubmed: 8130344
Science. 1998 Jun 5;280(5369):1610-3
pubmed: 9616125
Dev Biol. 1980 Jun 1;77(1):73-83
pubmed: 6772500
Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14605-10
pubmed: 19706548
Glia. 2019 Apr;67(4):634-649
pubmed: 30637801
J Neurosci Res. 2009 Nov 15;87(15):3465-79
pubmed: 19170188
Neuron. 1997 Jan;18(1):59-70
pubmed: 9010205
Nature. 2017 Sep 7;549(7670):106-110
pubmed: 28813410
J Neurosci. 2013 Aug 14;33(33):13569-80
pubmed: 23946415
Neuron. 2018 Dec 5;100(5):1097-1115.e15
pubmed: 30392800
Magn Reson Med. 2009 Feb;61(2):364-71
pubmed: 19165898
Glia. 2013 Nov;61(11):1832-47
pubmed: 24038504
Cell Rep. 2021 Jan 12;34(2):108610
pubmed: 33440165
Nature. 2019 Feb;566(7745):543-547
pubmed: 30747918
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9985-90
pubmed: 9707587
Glia. 2013 Jun;61(6):869-80
pubmed: 23483656
Nature. 2021 Aug;596(7873):583-589
pubmed: 34265844
J Cell Biol. 2005 Aug 1;170(3):349-55
pubmed: 16043516
Nat Rev Neurol. 2012 Nov 5;8(11):624-34
pubmed: 23026979
Proteomics. 2015 Sep;15(18):3140-51
pubmed: 25545627
Clin Transl Oncol. 2015 Jun;17(6):431-7
pubmed: 25387568
Physiol Rev. 2019 Jul 1;99(3):1381-1431
pubmed: 31066630
Mol Cell Neurosci. 2003 Apr;22(4):430-40
pubmed: 12727441
J Neurosci. 2000 Jul 15;20(14):5225-33
pubmed: 10884306
Elife. 2022 Mar 11;11:
pubmed: 35274615
Genesis. 2000 Nov-Dec;28(3-4):106-10
pubmed: 11105051
Glia. 2004 Sep;47(4):346-57
pubmed: 15293232
Front Neuroinform. 2014 Feb 21;8:8
pubmed: 24600385
Cell. 1985 Aug;42(1):149-55
pubmed: 2410137
Nat Neurosci. 2001 Dec;4(12):1199-206
pubmed: 11770485
Magn Reson Med. 1993 Dec;30(6):672-9
pubmed: 8139448
J Neurosci. 2011 Nov 9;31(45):16369-86
pubmed: 22072688
J Neurosci. 1996 Dec 15;16(24):7920-9
pubmed: 8987820
Nucleic Acids Res. 2019 Jan 8;47(D1):D442-D450
pubmed: 30395289
Elife. 2016 Aug 09;5:
pubmed: 27504968
Methods Cell Biol. 2010;96:475-512
pubmed: 20869535
Neuron. 2021 Nov 3;109(21):3456-3472.e8
pubmed: 34506725
J Neurosci. 2012 Aug 29;32(35):12192-203
pubmed: 22933801
Vision Res. 2006 Mar;46(6-7):902-13
pubmed: 16242750
Cell Death Differ. 2015 May;22(5):731-42
pubmed: 25323584
Cell Mol Life Sci. 2012 Sep;69(17):2879-94
pubmed: 22441408
J Cancer. 2020 Apr 6;11(13):3762-3770
pubmed: 32328181
J Neurosci Res. 1997 Oct 15;50(2):312-20
pubmed: 9373040
Curr Biol. 2007 Jan 9;17(1):R29-35
pubmed: 17208176
Nat Methods. 2014 Feb;11(2):167-70
pubmed: 24336358
PLoS Biol. 2010 Jan 26;8(1):e1000300
pubmed: 20126265
Nat Rev Neurol. 2021 Feb;17(2):88-103
pubmed: 33324001
J Struct Biol. 2020 May 1;210(2):107492
pubmed: 32156581
Nature. 2012 Jul 26;487(7408):443-8
pubmed: 22801498
J Neurosci. 2007 Sep 12;27(37):9817-23
pubmed: 17855595
J Neurosci. 2018 Jul 18;38(29):6586-6596
pubmed: 29941446
J Neurosci. 2003 Apr 1;23(7):2833-9
pubmed: 12684470
Nat Commun. 2020 Sep 9;11(1):4514
pubmed: 32908139
Mol Cell Proteomics. 2006 Jan;5(1):144-56
pubmed: 16219938
Bioorg Med Chem. 2020 Sep 15;28(18):115644
pubmed: 32828421
Glia. 2013 Apr;61(4):567-86
pubmed: 23322581
J Cell Biol. 2004 Jul 5;166(1):121-31
pubmed: 15226307
Nature. 2017 Sep 7;549(7670):101-105
pubmed: 28813417
Magn Reson Med. 2008 Dec;60(6):1396-407
pubmed: 19025906
Elife. 2020 Mar 04;9:
pubmed: 32130108
Glia. 2009 Dec;57(16):1815-24
pubmed: 19459211