Biocompatible poly(ethylene succinate) polyester with molecular weight dependent drug release properties.

Drug Carriers / chemistry Drug Liberation Molecular Weight Nanoparticles / chemistry Nimodipine Particle Size Polyesters / chemistry Polyethylene Glycols / chemistry Polyethylenes Polymers Succinates Water
Biocompatible polyester Different molecular weight Drug release control Nimodipine Poly(ethylene succinate)

Journal

International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127

Informations de publication

Date de publication:
25 Apr 2022
Historique:
received: 15 11 2021
revised: 04 02 2022
accepted: 07 03 2022
pubmed: 13 3 2022
medline: 14 4 2022
entrez: 12 3 2022
Statut: ppublish

Résumé

In the present study, we demonstrate that well-known molecular weight-dependent solubility properties of a polymer can also be used in the field of controlled drug delivery. To prove this, poly(ethylene succinate) (PES) polyesters with polycondensation time regulated molecular weights were synthesized via catalyst-free direct polymerization in an equimolar ratio of ethylene glycol and succinic acid monomers at 185 °C. DSC and contact angle measurements revealed that increasing the molecular weight (M

Identifiants

DOI: 10.1016/j.ijpharm.2022.121653 PMID: 35278604
pubmed: 35278604
pii: S0378-5173(22)00208-3
doi: 10.1016/j.ijpharm.2022.121653
pii:
doi:

Substances chimiques

Drug Carriers 0
Polyesters 0
Polyethylenes 0
Polymers 0
Succinates 0
poly(ethylene succinate) 0
Water 059QF0KO0R
Polyethylene Glycols 3WJQ0SDW1A
Nimodipine 57WA9QZ5WH

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

121653

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Mohamed M Abdelghafour (MM)

Department of Physical Chemistry and Materials Science, University of Szeged, H-6720, Rerrich Béla tér 1, Szeged, Hungary; Department of Chemistry, Faculty of Science, Zagazig University, Zagazig 44519, Egypt.

Ágoston Orbán (Á)

Department of Physical Chemistry and Materials Science, University of Szeged, H-6720, Rerrich Béla tér 1, Szeged, Hungary.

Ágota Deák (Á)

Department of Physical Chemistry and Materials Science, University of Szeged, H-6720, Rerrich Béla tér 1, Szeged, Hungary.

Łukasz Lamch (Ł)

Department of Organic and Pharmaceutical Technology, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland.

Éva Frank (É)

Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary.

Roland Nagy (R)

Department of MOL Department of Hydrocarbon and Coal Processing, Faculty of Engineering, University of Pannonia, Egyetem Str. 10, H-8200 Veszprém, Hungary.

Szilveszter Ziegenheim (S)

Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, H-6720 Szeged, Hungary.

Pál Sipos (P)

Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, H-6720 Szeged, Hungary.

Eszter Farkas (E)

Department of Medical Physics and Informatics, Faculty of Medicine & Faculty of Science and Informatics, University of Szeged, Korányi Fasor 9, H-6720 Szeged, Hungary; HCEMM-USZ Cerebral Blood Flow and Metabolism Research Group, University of Szeged, Dugonics Square 13, H-6720 Szeged, Hungary; Department of Cell Biology and Molecular Medicine, Faculty of Science and Informatics & Faculty of Medicine, University of Szeged, Somogyi Str. 4, H-6720 Szeged, Hungary.

Ferenc Bari (F)

Department of Medical Physics and Informatics, Faculty of Medicine & Faculty of Science and Informatics, University of Szeged, Korányi Fasor 9, H-6720 Szeged, Hungary.

László Janovák (L)

Department of Physical Chemistry and Materials Science, University of Szeged, H-6720, Rerrich Béla tér 1, Szeged, Hungary. Electronic address: janovakl@chem.u-szeged.hu.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Vecteurs de médicaments › Biocompatible poly(ethylene succinate)...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Libération de médicament › Biocompatible poly(ethylene succinate)...
questionsmedicales.fr › Phénomènes chimiques › Masse moléculaire › Biocompatible poly(ethylene succinate)...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Biocompatible poly(ethylene succinate)...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Acides nicotiniques › Nimodipine › Biocompatible poly(ethylene succinate)...
questionsmedicales.fr › Phénomènes chimiques › Taille de particule › Biocompatible poly(ethylene succinate)...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyesters › Biocompatible poly(ethylene succinate)...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyéthylène glycols › Biocompatible poly(ethylene succinate)...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Matières plastiques › Polyéthylènes › Biocompatible poly(ethylene succinate)...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Biocompatible poly(ethylene succinate)...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Diacides carboxyliques › Succinates › Biocompatible poly(ethylene succinate)...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Eau › Biocompatible poly(ethylene succinate)...