TSG-6 promotes Cancer Cell aggressiveness in a CD44-Dependent Manner and Reprograms Normal Fibroblasts to create a Pro-metastatic Microenvironment in Colorectal Cancer.

Animals Cancer-Associated Fibroblasts / metabolism Cell Line, Tumor Cell Movement / genetics Colorectal Neoplasms / metabolism Epithelial-Mesenchymal Transition / genetics Fibroblasts / metabolism Gene Expression Regulation, Neoplastic Signal Transduction / genetics Tumor Microenvironment / genetics
Colorectal Cancer Fibroblast Metastasis TSG-6

Journal

International journal of biological sciences
ISSN: 1449-2288
Titre abrégé: Int J Biol Sci
Pays: Australia
ID NLM: 101235568

Informations de publication

Date de publication:
2022
Historique:
received: 17 11 2021
accepted: 21 01 2022
entrez: 14 3 2022
pubmed: 15 3 2022
medline: 16 4 2022
Statut: epublish

Résumé

Tumor necrosis factor α stimulated gene 6 (TSG-6), a 30-KD secretory protein, plays an essential role in modulating inflammatory responses and extracellular matrix remodeling. However, little is known regarding the role of TSG-6 in human cancers. Here, we investigated the mechanism of action and the role of TSG-6 in colorectal cancer (CRC) metastasis. We found that TSG-6 was highly expressed in tumor tissues and was associated with poor prognosis and metastasis in CRC. Mechanistically, TSG-6 overexpression in CRC cells resulted in ERK activation and epithelial-mesenchymal transition by means of stabilizing CD44 and facilitating the CD44-EGFR complex formation on the cell membrane. Consequently, this resulted in the promotion of tumor migration and invasion both

Identifiants

DOI: 10.7150/ijbs.69178 PMID: 35280699 PMC: PMC8898369
pubmed: 35280699
doi: 10.7150/ijbs.69178
pii: ijbsv18p1677
pmc: PMC8898369
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1677-1694

Informations de copyright

© The author(s).

Déclaration de conflit d'intérêts

Competing Interests: The authors have declared that no competing interest exists.

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Auteurs

Binbin Liu (B)

Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510655, China.

Tengfei Liu (T)

Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510655, China.

Yiting Liu (Y)

Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510655, China.

Xingzhi Feng (X)

Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510655, China.

Xuefei Jiang (X)

Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510655, China.

Jiahui Long (J)

Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510655, China.

Shubiao Ye (S)

Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510655, China.

Daici Chen (D)

Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510655, China.

Jianping Wang (J)

Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510655, China.

Zihuan Yang (Z)

Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510655, China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › TSG-6 promotes Cancer Cell aggressiveness in a...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Fibroblastes associés au cancer › TSG-6 promotes Cancer Cell aggressiveness in a...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › TSG-6 promotes Cancer Cell aggressiveness in a...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › TSG-6 promotes Cancer Cell aggressiveness in a...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › TSG-6 promotes Cancer Cell aggressiveness in a...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transdifférenciation cellulaire › Transition épithélio-mésenchymateuse › TSG-6 promotes Cancer Cell aggressiveness in a...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › TSG-6 promotes Cancer Cell aggressiveness in a...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › TSG-6 promotes Cancer Cell aggressiveness in a...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › TSG-6 promotes Cancer Cell aggressiveness in a...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › TSG-6 promotes Cancer Cell aggressiveness in a...