Estradiol Ameliorates Acute Kidney Ischemia-Reperfusion Injury by Inhibiting the TGF-βRI-SMAD Pathway.
ERα
SMAD
TGF-βR1
estradiol
ischemia-reperfusion injury
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
26
11
2021
accepted:
17
01
2022
entrez:
14
3
2022
pubmed:
15
3
2022
medline:
3
5
2022
Statut:
epublish
Résumé
Renal ischemia-reperfusion injury (IRI) is less extensive in females than males in both animals and humans; however, this protection diminishes after menopause, suggesting that estrogen plays a pivotal role in IRI, but the underlying mechanism remains largely unknown. Our study found that 45 min of warm ischemia was sufficient to induce significant pathological changes without causing death in model animals. Compared with male rats, female rats exhibited less extensive apoptosis, kidney injury, and fibrosis; these effects were worsened in ovariectomized (OVX) rats and ameliorated upon estradiol (E
Identifiants
pubmed: 35281024
doi: 10.3389/fimmu.2022.822604
pmc: PMC8907449
doi:
Substances chimiques
Estrogen Receptor alpha
0
Estradiol
4TI98Z838E
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
822604Informations de copyright
Copyright © 2022 Ren, Li, Di, Xiong, Zhang, Ma, Bian, Lang, Ye and Wang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor NG declared a past coauthorship with one of the authors YW.
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