Simian Immunodeficiency Virus Infection Mediated Changes in Jejunum and Peripheral SARS-CoV-2 Receptor ACE2 and Associated Proteins or Genes in Rhesus Macaques.
Angiotensin-Converting Enzyme 2
/ metabolism
Animals
CD4-Positive T-Lymphocytes
/ immunology
Cells, Cultured
Cytokines
/ metabolism
Dipeptidyl Peptidase 4
/ metabolism
Gene Expression Regulation
Humans
Inflammation Mediators
Jejunum
/ metabolism
Macaca mulatta
Receptor, Angiotensin, Type 2
/ metabolism
Simian Acquired Immunodeficiency Syndrome
/ metabolism
Simian Immunodeficiency Virus
/ physiology
ACE2 regulation
AGTR2
MIP-1
SIV/HIV
enteroids/organoids
mucosal immunity
rhesus macaque
transcriptomics
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
14
12
2021
accepted:
04
02
2022
entrez:
14
3
2022
pubmed:
15
3
2022
medline:
22
3
2022
Statut:
epublish
Résumé
Angiotensin converting enzyme-2 (ACE2) and associated proteins play a pivotal role in various physiological and pathological events, such as immune activation, inflammation, gut barrier maintenance, intestinal stem cell proliferation, and apoptosis. Although many of these clinical events are quite significant in SIV/HIV infection, expression profiling of these proteins has not been well reported. Considering the different pathological consequences in the gut after HIV infection, we hypothesized that the expression of ACE2 and associated proteins of the Renin-angiotensin system (RAS) could be compromised after SIV/HIV infection. We quantified the gene expression of
Identifiants
pubmed: 35281029
doi: 10.3389/fimmu.2022.835686
pmc: PMC8914048
doi:
Substances chimiques
AGTR2 protein, human
0
Cytokines
0
Inflammation Mediators
0
Receptor, Angiotensin, Type 2
0
DPP4 protein, human
EC 3.4.14.5
Dipeptidyl Peptidase 4
EC 3.4.14.5
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
835686Subventions
Organisme : NIH HHS
ID : P51 OD011104
Pays : United States
Organisme : NCRR NIH HHS
ID : P51 RR000164
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK109883
Pays : United States
Informations de copyright
Copyright © 2022 Boby, Cao, Williams, Gadila, Shroyer, Didier, Srivastav, Das, Baker, Sha and Pahar.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Front Med (Lausanne). 2021 Jan 12;7:613475
pubmed: 33511147
BMC Genomics. 2017 Apr 18;18(1):305
pubmed: 28420336
Biomed Pharmacother. 2017 Oct;94:317-325
pubmed: 28772209
Inflamm Bowel Dis. 2020 May 12;26(6):797-808
pubmed: 32333601
Nat Protoc. 2008;3(6):1101-8
pubmed: 18546601
Cell. 2016 Apr 21;165(3):535-50
pubmed: 27104977
Biochem Biophys Res Commun. 2020 Dec 17;533(4):1276-1282
pubmed: 33097186
Gastroenterology. 2021 Feb;160(3):809-822.e7
pubmed: 33160965
Am J Physiol Gastrointest Liver Physiol. 2010 Apr;298(4):G504-17
pubmed: 20133952
Int J Exp Pathol. 2012 Apr;93(2):81-103
pubmed: 22414290
Curr Opin HIV AIDS. 2016 Mar;11(2):242-9
pubmed: 26845675
Arch Oral Biol. 2011 Mar;56(3):205-11
pubmed: 21109230
Cell Rep. 2020 Jul 7;32(1):107863
pubmed: 32610043
J Virol. 2014 Jan;88(2):1293-307
pubmed: 24227843
J Infect Dis. 1997 Dec;176(6):1621-4
pubmed: 9395378
Front Immunol. 2021 Nov 23;12:769990
pubmed: 34887863
Pathog Immun. 2020 Apr 24;5(1):68-88
pubmed: 32426577
Science. 2020 Nov 13;370(6518):856-860
pubmed: 33082293
Nat Rev Gastroenterol Hepatol. 2021 Apr;18(4):269-283
pubmed: 33589829
Am J Physiol. 1999 Mar;276(3):H786-92
pubmed: 10070060
Cell. 2018 Dec 13;175(7):1731-1743.e13
pubmed: 30503213
Curr Opin HIV AIDS. 2015 Jan;10(1):35-42
pubmed: 25415420
J Infect Dis. 2011 Mar 15;203(6):780-90
pubmed: 21252259
Int J Hypertens. 2012;2012:594361
pubmed: 22315665
Diabetes. 2020 Sep;69(9):1875-1886
pubmed: 32669391
J Infect Dis. 2014 Mar 1;209(5):739-48
pubmed: 24133185
JAMA Netw Open. 2021 Feb 1;4(2):e2037069
pubmed: 33533933
Biochem J. 1991 Dec 1;280 ( Pt 2):331-4
pubmed: 1747105
Antiviral Res. 2010 Mar;85(3):551-5
pubmed: 19995578
Diabetes. 2010 Feb;59(2):529-38
pubmed: 19934006
Endocrinology. 1999 Jan;140(1):500-9
pubmed: 9886863
Br J Pharmacol. 2017 May;174(9):737-753
pubmed: 28194766
J Virol. 2010 Jun;84(11):5605-14
pubmed: 20237084
Cell Host Microbe. 2016 Mar 9;19(3):280-91
pubmed: 26962940
Inflamm Allergy Drug Targets. 2014;13(4):224-34
pubmed: 25019157
Sci Immunol. 2020 May 13;5(47):
pubmed: 32404436
J Virol. 2013 Nov;87(21):11916-23
pubmed: 23966391
Eur J Immunol. 2006 Mar;36(3):583-92
pubmed: 16506292
Cell Rep. 2020 Sep 22;32(12):108175
pubmed: 32946807
Clin Immunol. 2015 May;158(1):8-18
pubmed: 25769244
Lancet HIV. 2021 Jan;8(1):e24-e32
pubmed: 33316211
Am J Physiol Gastrointest Liver Physiol. 2012 Sep 15;303(6):G686-95
pubmed: 22790597
Gut. 2020 May;69(5):841-851
pubmed: 31409604
Heart Fail Rev. 2012 Sep;17(4-5):683-91
pubmed: 21638102
Nature. 2002 Jun 20;417(6891):822-8
pubmed: 12075344
PLoS One. 2012;7(1):e30247
pubmed: 22291924
J Biol Chem. 2002 Apr 26;277(17):14838-43
pubmed: 11815627
J Virol. 2014 Nov;88(22):13015-28
pubmed: 25165117
Gastroenterology. 2013 Aug;145(2):383-95.e1-21
pubmed: 23644405
Lancet HIV. 2021 Sep;8(9):e554-e567
pubmed: 34363789
Cell Stem Cell. 2011 May 6;8(5):511-24
pubmed: 21419747
Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):156-60
pubmed: 8552595
IEEE/ACM Trans Comput Biol Bioinform. 2021 Jul-Aug;18(4):1230-1233
pubmed: 32750889
Circ Res. 2016 Apr 15;118(8):1313-26
pubmed: 27081112
Diabetes Res Clin Pract. 2021 Jul;177:108925
pubmed: 34166703
Stem Cell Reports. 2017 Dec 12;9(6):1976-1990
pubmed: 29153987
Cells. 2021 Apr 04;10(4):
pubmed: 33916615
Nat Commun. 2021 Feb 24;12(1):1260
pubmed: 33627662
Circ Res. 2000 Sep 1;87(5):E1-9
pubmed: 10969042
Development. 2010 May;137(9):1573-82
pubmed: 20388655
Gastroenterology. 1995 Jan;108(1):40-50
pubmed: 7806062
Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7809-14
pubmed: 18490652
Biochem Biophys Res Commun. 2020 May 21;526(1):135-140
pubmed: 32199615
Pulmonology. 2019 Sep - Oct;25(5):271-274
pubmed: 31076291
Lancet HIV. 2021 May;8(5):e294-e305
pubmed: 33915101
Int J Infect Dis. 2002 Sep;6(3):178-81
pubmed: 12718831
Int J Infect Dis. 2020 Jul;96:19-24
pubmed: 32311451
J Pharm Pharmacol. 2009 Apr;61(4):503-10
pubmed: 19298698
Virol J. 2016 Dec 1;13(1):200
pubmed: 27903274
BMC Infect Dis. 2016 Jun 01;16:241
pubmed: 27246604
Mol Syst Biol. 2020 Jul;16(7):e9610
pubmed: 32715618
Clin Infect Dis. 2021 Oct 5;73(7):e2095-e2106
pubmed: 33095853
J Virol. 2017 Sep 12;91(19):
pubmed: 28747502
J Vis Exp. 2015 Mar 06;(97):
pubmed: 25866936
J Exp Clin Cancer Res. 2017 Jun 9;36(1):77
pubmed: 28599664
Biochem Biophys Res Commun. 2012 Aug 10;424(4):663-8
pubmed: 22776205
Inflamm Bowel Dis. 2020 Nov 19;26(12):1787-1795
pubmed: 33064147
J Crohns Colitis. 2021 Mar 5;15(3):485-498
pubmed: 32915959
J Interferon Cytokine Res. 2009 Jun;29(6):313-26
pubmed: 19441883
Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1108-18
pubmed: 19228882
Microbes Infect. 2013 Nov;15(13):866-73
pubmed: 23962453
Brain Behav Immun. 2018 Mar;69:167-179
pubmed: 29155324
Gastroenterology. 2021 Jan;160(1):39-46
pubmed: 33130103
Med Hypotheses. 2020 Nov;144:110213
pubmed: 33254519
Front Immunol. 2019 Dec 13;10:2759
pubmed: 31921102
Nat Commun. 2021 Jun 10;12(1):3534
pubmed: 34112801
Nature. 2012 Jul 25;487(7408):477-81
pubmed: 22837003
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Science. 2020 Jul 3;369(6499):50-54
pubmed: 32358202
Front Microbiol. 2019 Dec 20;10:2933
pubmed: 31921088
Eur J Intern Med. 2020 Jun;76:14-20
pubmed: 32336612
Front Physiol. 2014 Jun 24;5:227
pubmed: 25009501
PLoS One. 2017 Sep 15;12(9):e0184845
pubmed: 28915252
Gastroenterology. 2009 Mar;136(3):872-82
pubmed: 19185582
EBioMedicine. 2020 Aug;58:102907
pubmed: 32771682
J Gen Virol. 2019 Jan;100(1):26-34
pubmed: 30480508