Olfactory threshold predicts treatment response in relapsing multiple sclerosis.
MRI
Multiple sclerosis
disease-modifying treatment
olfactory threshold
relapse
treatment response
Journal
Multiple sclerosis (Houndmills, Basingstoke, England)
ISSN: 1477-0970
Titre abrégé: Mult Scler
Pays: England
ID NLM: 9509185
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
pubmed:
15
3
2022
medline:
27
7
2022
entrez:
14
3
2022
Statut:
ppublish
Résumé
Olfactory threshold (OT) is associated with short-term inflammatory activity in relapsing multiple sclerosis (RMS). We aimed to investigate OT for prediction of treatment response in RMS. In this 5-year prospective study on 123 RMS patients, OT was measured at disease-modifying treatment (DMT) initiation (M0), after 3 months (M3), and 12 months (M12) by Sniffin' Sticks test. Primary endpoint was defined as an absence of relapse during the observation period, with Expanded Disability Status Scale (EDSS) progression and magnetic resonance imaging (MRI) activity being the secondary endpoints. Optimal cutoff values were determined by receiver operating characteristic analyses and their predictive value assessed by multivariable Cox regression models. Higher OT scores at M0, M3, and M12 were independently associated with decreased relapse probability with the strongest risk reduction at M3 (hazard ratio (HR) = 0.44, OT is an independent predictor of freedom of disease activity upon DMT initiation within 5 years and may be a useful biomarker of treatment response.
Sections du résumé
BACKGROUND
Olfactory threshold (OT) is associated with short-term inflammatory activity in relapsing multiple sclerosis (RMS).
OBJECTIVE
We aimed to investigate OT for prediction of treatment response in RMS.
METHODS
In this 5-year prospective study on 123 RMS patients, OT was measured at disease-modifying treatment (DMT) initiation (M0), after 3 months (M3), and 12 months (M12) by Sniffin' Sticks test. Primary endpoint was defined as an absence of relapse during the observation period, with Expanded Disability Status Scale (EDSS) progression and magnetic resonance imaging (MRI) activity being the secondary endpoints. Optimal cutoff values were determined by receiver operating characteristic analyses and their predictive value assessed by multivariable Cox regression models.
RESULTS
Higher OT scores at M0, M3, and M12 were independently associated with decreased relapse probability with the strongest risk reduction at M3 (hazard ratio (HR) = 0.44,
CONCLUSIONS
OT is an independent predictor of freedom of disease activity upon DMT initiation within 5 years and may be a useful biomarker of treatment response.
Identifiants
pubmed: 35282741
doi: 10.1177/13524585221079744
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1541-1552Commentaires et corrections
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