Exerkines and long-term synaptic potentiation: Mechanisms of exercise-induced neuroplasticity.

Cognition Exercise / physiology Hippocampus / physiology Long-Term Potentiation / physiology Neuronal Plasticity / physiology
Biomarkers Brain Cytokines Exercise Inflammation Intracellular signaling peptides and proteins Long-term potentiation Myokine Neurotrophic factor Synaptic plasticity

Journal

Frontiers in neuroendocrinology
ISSN: 1095-6808
Titre abrégé: Front Neuroendocrinol
Pays: United States
ID NLM: 7513292

Informations de publication

Date de publication:
07 2022
Historique:
received: 16 06 2021
revised: 03 03 2022
accepted: 06 03 2022
pubmed: 15 3 2022
medline: 16 8 2022
entrez: 14 3 2022
Statut: ppublish

Résumé

Physical exercise may improve cognitive function by modulating molecular and cellular mechanisms within the brain. We propose that the facilitation of long-term synaptic potentiation (LTP)-related pathways, by products induced by physical exercise (i.e., exerkines), is a crucial aspect of the exercise-effect on the brain. This review summarizes synaptic pathways that are activated by exerkines and may potentiate LTP. For a total of 16 exerkines, we indicated how blood and brain exerkine levels are altered depending on the type of physical exercise (i.e., cardiovascular or resistance exercise) and how they respond to a single bout (i.e., acute exercise) or multiple bouts of physical exercise (i.e., chronic exercise). This information may be used for designing individualized physical exercise programs. Finally, this review may serve to direct future research towards fundamental gaps in our current knowledge regarding the biophysical interactions between muscle activity and the brain at both cellular and system levels.

Identifiants

DOI: 10.1016/j.yfrne.2022.100993 PMID: 35283168
pubmed: 35283168
pii: S0091-3022(22)00016-4
doi: 10.1016/j.yfrne.2022.100993
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

100993

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Wouter A J Vints (WAJ)

Department of Health Promotion and Rehabilitation, Lithuanian Sports University, Sporto str. 6, LT-44221 Kaunas, Lithuania; Department of Rehabilitation Medicine Research School CAPHRI, Maastricht University, P.O. Box 616, 6200 MD Maastricht, the Netherlands; Centre of Expertise in Rehabilitation and Audiology, Adelante Zorggroep, P.O. Box 88, 6430 AB Hoensbroek, the Netherlands. Electronic address: w.vints@maastrichtuniversity.nl.

Oron Levin (O)

Department of Health Promotion and Rehabilitation, Lithuanian Sports University, Sporto str. 6, LT-44221 Kaunas, Lithuania; Movement Control & Neuroplasticity Research Group, Group Biomedical Sciences, Catholic University Leuven, Tervuursevest 101, 3001 Heverlee, Belgium. Electronic address: oron.levin@kuleuven.be.

Hakuei Fujiyama (H)

Department of Psychology, Murdoch University, 90 South St., WA 6150 Perth, Australia; Centre for Healthy Ageing, Health Futures Institute, Murdoch University, 90 South St., WA 6150 Perth, Australia; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, 90 South St., WA 6150 Perth, Australia. Electronic address: hakuei.fujiyama@murdoch.edu.au.

Jeanine Verbunt (J)

Department of Rehabilitation Medicine Research School CAPHRI, Maastricht University, P.O. Box 616, 6200 MD Maastricht, the Netherlands; Centre of Expertise in Rehabilitation and Audiology, Adelante Zorggroep, P.O. Box 88, 6430 AB Hoensbroek, the Netherlands. Electronic address: jeanine.verbunt@maastrichtuniversity.nl.

Nerijus Masiulis (N)

Department of Health Promotion and Rehabilitation, Lithuanian Sports University, Sporto str. 6, LT-44221 Kaunas, Lithuania; Department of Rehabilitation, Physical and Sports Medicine, Institute of Health Science, Faculty of Medicine, Vilnius University, M. K. Čiurlionio Str. 21, LT-03101 Vilnius, Lithuania. Electronic address: nerijus.masiulis@lsu.lt.

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Classifications MeSH

questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Exerkines and long-term synaptic potentiation:...
questionsmedicales.fr › Activités humaines › Exercice physique › Exerkines and long-term synaptic potentiation:...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Exerkines and long-term synaptic potentiation:...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › Potentialisation à long terme › Exerkines and long-term synaptic potentiation:...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › Exerkines and long-term synaptic potentiation:...