Anti-Zika Virus Activity of Plant Extracts Containing Polyphenols and Triterpenes on Vero CCL-81 and Human Neuroblastoma SH-SY5Y Cells.
Maytenus ilicifolia
SH-SY5Y cells
Terminalia phaeocarpa
Zika virus inhibition
chemosystematic approach
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
08
11
2021
accepted:
09
03
2022
pubmed:
15
3
2022
medline:
23
4
2022
entrez:
14
3
2022
Statut:
ppublish
Résumé
Zika virus (ZIKV) infection is a global threat associated to neurological disorders in adults and microcephaly in children born to infected mothers. No vaccine or drug is available against ZIKV. We herein report the anti-ZIKV activity of 36 plant extracts containing polyphenols and/or triterpenes. ZIKV-infected Vero CCL-81 cells were treated with samples at non-cytotoxic concentrations, determined by MTT and LDH assays. One third of the extracts elicited concentration-dependent anti-ZIKV effect, with viral loads reduction from 0.4 to 3.8 log units. The 12 active extracts were tested on ZIKV-infected SH-SY5Y cells and significant reductions of viral loads (in log units) were induced by Maytenus ilicifolia (4.5 log), Terminalia phaeocarpa (3.7 log), Maytenus rigida (1.7 log) and Echinodorus grandiflorus (1.7 log) extracts. Median cytotoxic concentration (CC
Identifiants
pubmed: 35285139
doi: 10.1002/cbdv.202100842
doi:
Substances chimiques
Plant Extracts
0
Polyphenols
0
Triterpenes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202100842Subventions
Organisme : UFMG
Organisme : Brazilian agencies CNPq
ID : 421563/2018-4
Organisme : Brazilian agencies CNPq
ID : 440423/2016-13
Organisme : Brazilian agencies CNPq
ID : 425359/2018-2
Organisme : Brazilian agencies CNPq
ID : 421375/2017-5
Organisme : CAPES
ID : 88881.130741
Organisme : FAPEMIG
ID : APQ-02281-18
Organisme : FINEP
ID : 01.16.0050.00
Organisme : ZIKALLIANCE consortium
ID : 734548
Organisme : National Institute of Science and Technology
ID : 465425/2014-3
Organisme : L'Oréal-UNESCO-ABC
Organisme : CAPES
Organisme : CNPq
Informations de copyright
© 2022 Wiley-VHCA AG, Zurich, Switzerland.
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