Per- and Polyfluoroalkyl Substances and Risk of Myocardial Infarction and Stroke: A Nested Case-Control Study in Sweden.
Journal
Environmental health perspectives
ISSN: 1552-9924
Titre abrégé: Environ Health Perspect
Pays: United States
ID NLM: 0330411
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
entrez:
14
3
2022
pubmed:
15
3
2022
medline:
18
3
2022
Statut:
ppublish
Résumé
Per- and polyfluoroalkyl substances (PFAS) are widespread and persistent pollutants that have been associated with elevated cholesterol levels. However, data on incident cardiovascular disease (CVD) is lacking. We investigated the association of exposure to PFAS with risk of myocardial infarction and stroke and, subsidiary, with baseline blood lipids. This population-based nested case-control study included first incident myocardial infarction and stroke cases with matched controls from two Swedish cohorts: the Swedish Mammography Cohort-Clinical (SMC-C) and the Cohort of 60-year-olds (60YO). Baseline blood sampling occurred during 2003-2009 and 1997-1999 with follow-up through 2017 and 2014 for the SMC-C and the 60YO, respectively. Eight plasma PFAS concentrations were measured using targeted liquid chromatography-triple quadrupole mass spectrometry. Five of these were quantifiable in both cohorts; individual values and their standardized sum were categorized into tertiles based on the controls. First incident myocardial infarction ( Among the 1,528 case-control subjects, the mean (standard deviation) age was 66 (7.7) y and 67% of them were women. In multivariable-adjusted analyses, the third tertile of the standardized sum of five PFAS associated with higher cholesterol and lower triglyceride levels among controls at baseline ( This study indicated that exposure to PFAS, although associated with increased cholesterol levels, did not associate with an increased risk of myocardial infarction, stroke, or their composite end point. The findings improve our knowledge on potential health effects of environmental contaminants in the CVD context. https://doi.org/10.1289/EHP9791.
Sections du résumé
BACKGROUND
Per- and polyfluoroalkyl substances (PFAS) are widespread and persistent pollutants that have been associated with elevated cholesterol levels. However, data on incident cardiovascular disease (CVD) is lacking.
OBJECTIVES
We investigated the association of exposure to PFAS with risk of myocardial infarction and stroke and, subsidiary, with baseline blood lipids.
METHODS
This population-based nested case-control study included first incident myocardial infarction and stroke cases with matched controls from two Swedish cohorts: the Swedish Mammography Cohort-Clinical (SMC-C) and the Cohort of 60-year-olds (60YO). Baseline blood sampling occurred during 2003-2009 and 1997-1999 with follow-up through 2017 and 2014 for the SMC-C and the 60YO, respectively. Eight plasma PFAS concentrations were measured using targeted liquid chromatography-triple quadrupole mass spectrometry. Five of these were quantifiable in both cohorts; individual values and their standardized sum were categorized into tertiles based on the controls. First incident myocardial infarction (
RESULTS
Among the 1,528 case-control subjects, the mean (standard deviation) age was 66 (7.7) y and 67% of them were women. In multivariable-adjusted analyses, the third tertile of the standardized sum of five PFAS associated with higher cholesterol and lower triglyceride levels among controls at baseline (
DISCUSSION
This study indicated that exposure to PFAS, although associated with increased cholesterol levels, did not associate with an increased risk of myocardial infarction, stroke, or their composite end point. The findings improve our knowledge on potential health effects of environmental contaminants in the CVD context. https://doi.org/10.1289/EHP9791.
Identifiants
pubmed: 35285690
doi: 10.1289/EHP9791
pmc: PMC8919955
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
37007Références
EFSA J. 2018 Dec 13;16(12):e05194
pubmed: 32625773
Toxicol Sci. 2009 Sep;111(1):89-99
pubmed: 19407336
Environ Int. 2018 Oct;119:37-46
pubmed: 29933236
Lancet. 2012 Aug 11;380(9841):581-90
pubmed: 22607822
Lancet Glob Health. 2019 Jun;7(6):e748-e760
pubmed: 31028013
Atherosclerosis. 2015 Nov;243(1):93-8
pubmed: 26363438
Environ Int. 2016 Sep;94:292-299
pubmed: 27288966
Lancet Digit Health. 2021 Jul;3(7):e434-e444
pubmed: 34167764
BMJ Nutr Prev Health. 2020 Nov 4;3(2):277-284
pubmed: 33521539
Toxicol Sci. 2011 Mar;120(1):42-58
pubmed: 21163906
Basic Res Cardiol. 2020 Nov 30;115(6):73
pubmed: 33258000
Arch Pediatr Adolesc Med. 2010 Sep;164(9):860-9
pubmed: 20819969
JAMA. 2009 Nov 11;302(18):1993-2000
pubmed: 19903920
Clin Sci (Lond). 2018 Jun 21;132(12):1243-1252
pubmed: 29930142
Diabetes Metab. 2007 Feb;33(1):30-6
pubmed: 17258927
Environ Int. 2021 Oct;155:106716
pubmed: 34144476
Sci Total Environ. 2019 Feb 25;653:74-81
pubmed: 30408670
Lancet. 2007 Dec 1;370(9602):1829-39
pubmed: 18061058
J Agric Food Chem. 2017 Jan 25;65(3):533-543
pubmed: 28052194
N Engl J Med. 2012 Nov 29;367(22):2089-99
pubmed: 23126252
Lancet. 2020 Mar 7;395(10226):795-808
pubmed: 31492503
Epidemiology. 2013 Jul;24(4):569-76
pubmed: 23685825
Toxicol Sci. 2017 Dec 1;160(2):284-298
pubmed: 28973659
J Expo Sci Environ Epidemiol. 2019 Mar;29(2):148-156
pubmed: 30482935
Rev Environ Health. 2008 Jul-Sep;23(3):167-202
pubmed: 19119685
Toxics. 2020 Dec 20;8(4):
pubmed: 33419269
Eur J Public Health. 2018 Feb 1;28(1):180-185
pubmed: 28541558
Circ Res. 2016 Feb 19;118(4):579-85
pubmed: 26892959
Environ Health. 2018 Jul 3;17(1):59
pubmed: 29970113
Ecotoxicol Environ Saf. 2019 May 30;173:461-468
pubmed: 30798190
Toxicol Sci. 2011 Sep;123(1):290-303
pubmed: 21705711
Toxicol Lett. 2013 Apr 12;218(2):97-104
pubmed: 23391484
Arch Cardiovasc Dis. 2021 Feb;114(2):132-139
pubmed: 33546998
Environ Res. 2017 Jan;152:157-164
pubmed: 27771570
Aquat Toxicol. 2007 May 1;82(2):135-43
pubmed: 17374408
Crit Rev Toxicol. 2009;39(1):76-94
pubmed: 18802816
Am J Med. 2014 Sep;127(9):848-57.e2
pubmed: 24802020
Lancet. 2016 Oct 8;388(10053):1659-1724
pubmed: 27733284
Toxicol Sci. 2015 Aug;146(2):363-73
pubmed: 26001962
Curr Opin Endocrinol Diabetes Obes. 2013 Apr;20(2):132-9
pubmed: 23422242
Environ Int. 2020 Dec;145:106125
pubmed: 32950793
Nutr Metab Cardiovasc Dis. 2007 Jun;17(5):349-57
pubmed: 17562572
Environ Int. 2021 Jun;151:106446
pubmed: 33631604
Arch Intern Med. 2012 Oct 8;172(18):1397-403
pubmed: 22945282
Environ Int. 2019 Feb;123:390-398
pubmed: 30622063
J Immunotoxicol. 2017 Dec;14(1):188-195
pubmed: 28805477
Atherosclerosis. 2017 Nov;266:87-94
pubmed: 28992469
Arch Toxicol. 2017 Jun;91(6):2365-2374
pubmed: 27832320
Environ Int. 2012 Nov 15;49:120-7
pubmed: 23018201
Am J Epidemiol. 2009 Nov 15;170(10):1268-78
pubmed: 19846564
Toxicol Rep. 2016;3:46-54
pubmed: 26942110
Diab Vasc Dis Res. 2020 Jan-Feb;17(1):1479164119892223
pubmed: 31841043
Environ Int. 2013 Jul;57-58:2-10
pubmed: 23624243
Lancet Diabetes Endocrinol. 2020 Aug;8(8):703-718
pubmed: 32707118
Environ Int. 2020 Apr;137:105324
pubmed: 32109724
Arch Toxicol. 2020 May;94(5):1673-1686
pubmed: 32253466
Environ Health Perspect. 2014 Dec;122(12):1299-305
pubmed: 25260175
Lancet. 2003 Mar 1;361(9359):777-80
pubmed: 12620753
Environ Res. 2015 Oct;142:148-54
pubmed: 26142720
Toxicol Sci. 2008 Nov;106(1):162-71
pubmed: 18713766
J Expo Sci Environ Epidemiol. 2019 Mar;29(2):131-147
pubmed: 30470793
BMC Public Health. 2011 Jun 09;11:450
pubmed: 21658213
Toxicol Sci. 2007 Oct;99(2):366-94
pubmed: 17519394
Environ Int. 2020 Dec;145:106099
pubmed: 32916415