Relationship between biomarkers of tubular injury and intrarenal hemodynamic dysfunction in youth with type 1 diabetes.

Adolescent Humans Lipocalin-2 Diabetes Mellitus, Type 1 / complications Interleukin-18 Chitinase-3-Like Protein 1 Chemokine CCL2 Creatinine Glycated Hemoglobin Biomarkers Hemodynamics Albumins
Biomarkers Diabetic kidney disease KIM-1 Pediatrics Tubular injury YKL-40

Journal

Pediatric nephrology (Berlin, Germany)
ISSN: 1432-198X
Titre abrégé: Pediatr Nephrol
Pays: Germany
ID NLM: 8708728

Informations de publication

Date de publication:
12 2022
Historique:
received: 24 09 2021
accepted: 31 01 2022
revised: 29 01 2022
pubmed: 15 3 2022
medline: 26 10 2022
entrez: 14 3 2022
Statut: ppublish

Résumé

Early identification of youth with type 1 diabetes (T1D) at risk for diabetic kidney disease may improve clinical outcomes. We examined the cross-sectional relationship between kidney biomarkers neutrophil gelatinase-associated lipocalin (NGAL), copeptin, interleukin-18 (IL-18), kidney injury molecule-1 (KIM-1), chitinase-3-like protein-1 (YKL-40), and monocyte chemoattractant protein-1 (MCP-1) and intrarenal hemodynamic function in adolescents with T1D. Urine albumin-to-creatinine ratio (UACR), renal vascular resistance (RVR), glomerular filtration rate (GFR), intraglomerular pressure (P Fifty adolescents with T1D (16.1 ± 3.0 years, HbA1c 8.6 ± 1.2%) and 20 adolescents of comparable BMI without T1D (16.1 ± 2.9 years, HbA1c 5.2 ± 0.2%) were enrolled. Adolescents with T1D demonstrated significantly higher GFR, RPF, R Higher concentrations of biomarkers YKL-40 and KIM-1 may help define the risk for intraglomerular hemodynamic dysfunction in youth with T1D. A higher resolution version of the Graphical abstract is available as Supplementary information.

Sections du résumé

BACKGROUND
Early identification of youth with type 1 diabetes (T1D) at risk for diabetic kidney disease may improve clinical outcomes. We examined the cross-sectional relationship between kidney biomarkers neutrophil gelatinase-associated lipocalin (NGAL), copeptin, interleukin-18 (IL-18), kidney injury molecule-1 (KIM-1), chitinase-3-like protein-1 (YKL-40), and monocyte chemoattractant protein-1 (MCP-1) and intrarenal hemodynamic function in adolescents with T1D.
METHODS
Urine albumin-to-creatinine ratio (UACR), renal vascular resistance (RVR), glomerular filtration rate (GFR), intraglomerular pressure (P
RESULTS
Fifty adolescents with T1D (16.1 ± 3.0 years, HbA1c 8.6 ± 1.2%) and 20 adolescents of comparable BMI without T1D (16.1 ± 2.9 years, HbA1c 5.2 ± 0.2%) were enrolled. Adolescents with T1D demonstrated significantly higher GFR, RPF, R
CONCLUSIONS
Higher concentrations of biomarkers YKL-40 and KIM-1 may help define the risk for intraglomerular hemodynamic dysfunction in youth with T1D. A higher resolution version of the Graphical abstract is available as Supplementary information.

Identifiants

DOI: 10.1007/s00467-022-05487-4 PMID: 35286453 PMC: PMC9470783
pubmed: 35286453
doi: 10.1007/s00467-022-05487-4
pii: 10.1007/s00467-022-05487-4
pmc: PMC9470783
mid: NIHMS1800758
doi:

Substances chimiques

Lipocalin-2 0
Interleukin-18 0
Chitinase-3-Like Protein 1 0
Chemokine CCL2 0
Creatinine AYI8EX34EU
Glycated Hemoglobin A 0
Biomarkers 0
Albumins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

3085-3092

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL085757
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK093770
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK106962
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK116073
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23 DK116720
Pays : United States
Organisme : NIDDK NIH HHS
ID : UH3 DK114866
Pays : United States
Organisme : NIDDK NIH HHS
ID : R21 DK129720
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK114886
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL159292
Pays : United States
Organisme : NHLBI NIH HHS
ID : L40 HL159798
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK129211
Pays : United States

Informations de copyright

© 2022. The Author(s), under exclusive licence to International Pediatric Nephrology Association.

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Auteurs

Melissa J Johnson (MJ)

Department of Pediatrics, Section of Pediatric Endocrinology, Children's Hospital Colorado and University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Kalie L Tommerdahl (KL)

Department of Pediatrics, Section of Pediatric Endocrinology, Children's Hospital Colorado and University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO, USA.
Ludeman Center for Women's Health Research, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Carissa Vinovskis (C)

Department of Pediatrics, Section of Pediatric Endocrinology, Children's Hospital Colorado and University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Sushrut Waikar (S)

Section of Nephrology, Boston University School of Medicine and Boston Medical Center, Boston, MA, USA.

Trenton Reinicke (T)

Department of Pediatrics, Section of Pediatric Endocrinology, Children's Hospital Colorado and University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Chirag R Parikh (CR)

Division of Nephrology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Wassim Obeid (W)

Division of Nephrology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Robert G Nelson (RG)

Chronic Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA.

Daniel H van Raalte (DH)

Diabetes Center, Department of Internal Medicine, Amsterdam University Medical Centers, location VUMC, Amsterdam, The Netherlands.

Laura Pyle (L)

Department of Biostatistics, Colorado School of Public Health, Aurora, CO, USA.

Kristen J Nadeau (KJ)

Department of Pediatrics, Section of Pediatric Endocrinology, Children's Hospital Colorado and University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Ludeman Center for Women's Health Research, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Petter Bjornstad (P)

Department of Pediatrics, Section of Pediatric Endocrinology, Children's Hospital Colorado and University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Petter.Bjornstad@childrenscolorado.org.
Ludeman Center for Women's Health Research, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Petter.Bjornstad@childrenscolorado.org.
Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, 13123 E. 16th AveBox B265, Aurora, CO, USA. Petter.Bjornstad@childrenscolorado.org.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Relationship between biomarkers of tubular...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Relationship between biomarkers of tubular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Lipocaline-2 › Relationship between biomarkers of tubular...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Diabète de type 1 › Relationship between biomarkers of tubular...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-18 › Relationship between biomarkers of tubular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lectines › Protéine-1 similaire à la chitinase-3 › Relationship between biomarkers of tubular...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Chimiokines › Chimiokines CC › Protéines chimioattractives monocytaires › Chimiokine CCL2 › Relationship between biomarkers of tubular...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Créatinine › Relationship between biomarkers of tubular...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Produits terminaux de glycation avancée › Protéines glyquées › Protéine glycosylée sérique › Hémoglobine glycosylée › Relationship between biomarkers of tubular...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Relationship between biomarkers of tubular...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Relationship between biomarkers of tubular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Albumines › Relationship between biomarkers of tubular...