The Transformative Power of Biocatalysis in Convergent Synthesis.
Journal
Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056
Informations de publication
Date de publication:
30 03 2022
30 03 2022
Historique:
pubmed:
16
3
2022
medline:
29
4
2022
entrez:
15
3
2022
Statut:
ppublish
Résumé
Achieving convergent synthetic strategies has long been a gold standard in constructing complex molecular skeletons, allowing for the rapid generation of complexity in comparatively streamlined synthetic routes. Traditionally, biocatalysis has not played a prominent role in convergent laboratory synthesis, with the application of biocatalysts in convergent strategies primarily limited to the synthesis of chiral fragments. Although the use of enzymes to enable convergent synthetic approaches is relatively new and emerging, combining the efficiency of convergent transformations with the selectivity achievable through biocatalysis creates new opportunities for efficient synthetic strategies. This Perspective provides an overview of recent developments in biocatalytic strategies for convergent transformations and offers insights into the advantages of these methods compared to their small molecule-based counterparts.
Identifiants
pubmed: 35290055
doi: 10.1021/jacs.2c00224
pmc: PMC10082969
mid: NIHMS1853510
doi:
Substances chimiques
Enzymes
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
5214-5225Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM124880
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM145304
Pays : United States
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